First Presentation of an Acquired Demyelinating Syndrome

Rachel Gottlieb-Smith; Amy T. Waldman

doi:10.1055/s-0037-1606380

Journal of Pediatric Neurology, Table of Contents

Journal of Pediatric Neurology 2018; 16(03): 164-170
DOI: 10.1055/s-0037-1606380

Review Article

Georg Thieme Verlag KG Stuttgart · New York

First Presentation of an Acquired Demyelinating Syndrome

Authors

Rachel Gottlieb-Smith

¹Division of Child Neurology, Departments of Neurology and Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
Amy T. Waldman

¹Division of Child Neurology, Departments of Neurology and Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States

Abstract

Acquired demyelinating syndromes (ADS) present with acute or subacute monofocal or polyfocal neurologic deficits localizing to the central nervous system. The clinical features of distinct ADS have been carefully characterized including optic neuritis, transverse myelitis, and acute disseminated encephalomyelitis. These disorders may all be monophasic disorders. Alternatively, optic neuritis, partial transverse myelitis, and acute disseminated encephalomyelitis may be first presentations of a relapsing or polyphasic neuroinflammatory disorder, such as multiple sclerosis or neuromyelitis optica. The clinical features of these disorders and the differential diagnosis are discussed in this article.

Keywords

optic neuritis - transverse myelitis - acute disseminated encephalomyelitis

Full Text

References

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