Planta Medica International Open 2017; 4(S 01): S1-S202
DOI: 10.1055/s-0037-1608262
Poster Session
Georg Thieme Verlag KG Stuttgart · New York

Chemical constituents from the groundnuts of Apios americana

JH Jeon
1   Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon, Korea, Republic of (South)
2   2Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul, Korea, Republic of (South)
,
H Seo Young
1   Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon, Korea, Republic of (South)
2   2Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul, Korea, Republic of (South)
,
K Jeon Won
1   Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon, Korea, Republic of (South)
2   2Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul, Korea, Republic of (South)
,
MS Kim
1   Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon, Korea, Republic of (South)
2   2Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul, Korea, Republic of (South)
,
D Lee
3   Department of Biosystems and Biotechnology, Korea University, Seoul, Korea, Republic of (South)
,
M Ryu Seung
3   Department of Biosystems and Biotechnology, Korea University, Seoul, Korea, Republic of (South)
,
S Jang Dae
4   Department of Pharmaceutical Science, Graduate School, Kyung Hee University, Seoul, Korea, Republic of (South)
,
J Lee
1   Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon, Korea, Republic of (South)
2   2Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul, Korea, Republic of (South)
› Author Affiliations
Further Information

Publication History

Publication Date:
24 October 2017 (online)

 
 

    Phytochemical investigation of the groundnuts of Apios americana has resulted in the isolation of three new isoflavonoids (1–3) along with seventeen known compounds (4–20) by chromatographic separation methods [1 – 5]. The structures of all compounds were elucidated by spectroscopic methods including 1D-NMR (1H, 13C), 2D-NMR (DEPT, HSQC, COSY, HMBC, and NOESY), and HRESIMS. The absolute configuration of chiral centers in compound 1 was determined by electronic circular dichroism (ECD) study. Three of these compounds (4, 5, and 20) were identified in and isolated from this species for the first time. Biological activities of the compounds (1–20) were also evaluated in this study.

    [1] Ichige M, Fukuda E, Miida S, Hattan J, Misawa N, Saito S, Fujimaki T, Imoto M, Shindo K. J Agric Food Chem 2013; 61: 2183 – 2187

    [2] Haruna K, Koda M, Saito S, Imoto M, Kawada M, Yamazaki Y, Momose I, Shindo K. Biosci Biotech Biochem 2016; 80: 774 – 778

    [3] Zhao S, Zhang L, Gao P, Shao Z. Food Chem 2009; 114: 869 – 873

    [4] Selepe MA, Drewes SE, van Heerden FR. Tetrahedron 2011; 67: 8654 – 8658

    [5] Shibuya Y, Tahara S, Kimura Y, Mizutani J. J Biosci 1991; 46: 513 – 518


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