Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000068.xml
Semin intervent Radiol 2017; 34(04): 409-414
DOI: 10.1055/s-0037-1608864
DOI: 10.1055/s-0037-1608864
Clinical Corner
Heparin-Induced Thrombocytopenia and Thrombosis: Preventing your Thrombolysis Practice from Taking a HITT
Further Information
Publication History
Publication Date:
14 December 2017 (online)
![](https://www.thieme-connect.de/media/sir/201704/lookinside/thumbnails/10-1055-s-0037-1608864_001045-1.jpg)
Abstract
Heparin-induced thrombocytopenia and thrombosis (HITT) is an under-recognized cause of deep venous thrombosis treatment failure and of complications during catheter-directed thrombolysis. After a review of HITT pathophysiology, diagnosis, and management, three different cases are presented in this article. Each case highlights subtleties and challenges of HITT diagnosis and management. An example of a practical approach to the diagnosis of HITT is presented.
-
References
- 1 Chong BH. Heparin-induced thrombocytopenia. J Thromb Haemost 2003; 1 (07) 1471-1478
- 2 Ahmed I, Majeed A, Powell R. Heparin induced thrombocytopenia: diagnosis and management update. Postgrad Med J 2007; 83 (983) 575-582
- 3 Gupta S, Tiruvoipati R, Green C, Botha J, Tran H. Heparin induced thrombocytopenia in critically ill: diagnostic dilemmas and management conundrums. World J Crit Care Med 2015; 4 (03) 202-212
- 4 Shaikh N. Heparin-induced thrombocytopenia. J Emerg Trauma Shock 2011; 4 (01) 97-102
- 5 Levy JH, Hursting MJ. Heparin-induced thrombocytopenia, a prothrombotic disease. Hematol Oncol Clin North Am 2007; 21 (01) 65-88
- 6 Bakchoul T, Zöllner H, Greinacher A. Current insights into the laboratory diagnosis of HIT. Int J Lab Hematol 2014; 36 (03) 296-305
- 7 Lo GK, Juhl D, Warkentin TE, Sigouin CS, Eichler P, Greinacher A. Evaluation of pretest clinical score (4 T's) for the diagnosis of heparin-induced thrombocytopenia in two clinical settings. J Thromb Haemost 2006; 4 (04) 759-765
- 8 Joseph L, Gomes MP, Al Solaiman F. , et al. External validation of the HIT Expert Probability (HEP) score. Thromb Haemost 2015; 113 (03) 633-640
- 9 Demma LJ, Winkler AM, Levy JH. A diagnosis of heparin-induced thrombocytopenia with combined clinical and laboratory methods in cardiothoracic surgical intensive care unit patients. Anesth Analg 2011; 113 (04) 697-702
- 10 McFarland J, Lochowicz A, Aster R, Chappell B, Curtis B. Improving the specificity of the PF4 ELISA in diagnosing heparin-induced thrombocytopenia. Am J Hematol 2012; 87 (08) 776-781
- 11 Mullier F, Minet V, Bailly N. , et al. Platelet microparticle generation assay: a valuable test for immune heparin-induced thrombocytopenia diagnosis. Thromb Res 2014; 133 (06) 1068-1073
- 12 Marler J, Unzaga J, Stelts S, Oliphant CS. Consequences of treating false positive heparin-induced thrombocytopenia. J Thromb Thrombolysis 2015; 40 (04) 512-514
- 13 Ortel TL. Heparin-induced thrombocytopenia: when a low platelet count is a mandate for anticoagulation. Hematology (Am Soc Hematol Educ Program) 2009; 1: 225-232
- 14 Cosmi B. Current management of heparin-induced thrombocytopenia. Expert Rev Hematol 2015; 8 (06) 837-849
- 15 Baldwin ZK, Spitzer AL, Ng VL, Harken AH. Contemporary standards for the diagnosis and treatment of heparin-induced thrombocytopenia (HIT). Surgery 2008; 143 (03) 305-312