Room Temperature, Metal-Free, Radical Chloroazidation of 1,6-Enynes

Abstract

Without employing any transition metal, a mild, practical, and environmentally attractive methodology has been developed for the chloroazidation of 1,6-enynes at room temperature. In this radical cascade process, three new chemical bonds, including C–Cl (Br, I), C–N, and C–C bonds, are formed in one step for the construction of 2-pyrrolidinones. The method is valuable because of its mild reaction conditions, operational simplicity, and the rich biological activity of the corresponding 2-pyrrolidinone products.

Key words

room-temperature reactions - metal-free reactions - radicals - cascade processes

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