Abstract
The functionalization of typically unreactive C(sp3)–H bonds holds great promise for reducing the reliance on existing functional groups while improving atom-economy and energy efficiency. As a result, this topic is a matter of genuine concern for scientists in order to achieve greener chemical processes. The site-specific modification of α-amino acid and peptides based upon C(sp3)–H functionalization still represents a great challenge of utmost synthetic importance. This short review summarizes the most recent advances in ‘Cross-Dehydrogenative Couplings’ of α-amino carbonyl compounds and peptide derivatives with a variety of nucleophilic coupling partners.
1 Introduction
2 C–C Bond-Forming Oxidative Couplings
2.1 Reaction with Alkynes
2.2 Reaction with Alkenes
2.3 Reaction with (Hetero)arenes
2.4 Reaction with Alkyl Reagents
3 C–Heteroatom Bond-Forming Oxidative Couplings
3.1 C–P Bond Formation
3.2 C–N Bond Formation
3.3 C–O and C–S Bond Formation
4 Conclusions
Key words
cross-dehydrogenative coupling - peptide - α-amino acid - oxidative - C–H functionalization
