Synthesis, Table of Contents Synthesis 2019; 51(06): 1377-1382DOI: 10.1055/s-0037-1610670 paper © Georg Thieme Verlag Stuttgart · New York Synthesis of Novel Isoquinolino[5,4-ab]phenanthridine Derivatives via Pictet–Spengler Reaction Min-Chen Tsai , Pei Yu Huang , Liang Sheng Syu , Tzenge-Lien Shih* Department of Chemistry, Tamkang University, 25137 Tamsui Dist., New Taipei City, Taiwan, Republic of China Email: tlshih@mail.tku.edu.tw › Author Affiliations Recommend Article Abstract Buy Article All articles of this category Abstract The reaction of 5-amino-2-[2-(dimethylamino)ethyl]-6-phenyl-1H-benzo[de]isoquinoline-1,3(2H)-dione with a series of aldehydes in acidic media (phosphoric acid, trifluoromethanesulfonic acid, and trifluoroacetic acid) is described. This key step is based on the Pictet–Spengler reaction to synthesize ten novel isoquinolino[5,4-ab]phenanthridine derivatives. The most effective acid is phosphoric acid and optimized yields were obtained. 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