Synthesis of 2-[(5-Amino-1H-pyrrol-2-yl)sulfanyl]acetic Acid Esters: One-Pot Assembly from Propargyl Amines, Isothiocyanates, and Alkyl­ 2-Bromoacetates

Abstract

2-[(5-Amino-1H-pyrrol-2-yl)sulfanyl]acetic acid esters have been synthesized in up to 77% yield by the one-pot reaction of lithiated propargylamines with isothiocyanates followed by sequential treatment with t-BuOK–DMSO and alkyl 2-bromoacetates. The process occurs through the initial formation of the thiophene core, followed by its recyclization into the pyrrole nucleus at a higher temperature (ca. 45–60 °C).

Keywords

2-[(5-amino-1H-pyrrol-2-yl)sulfanyl]acetic acid derivatives - lithiated propargylamines - isothiocyanates - alkyl 2-bromoacetates

• References

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