Green Access to α-Haloalkyl and α-Halobenzyl Esters, Versatile Intermediates for the One-Pot Two-Step Synthesis of O,O′-Diacyl Acetals Using Zinc-Based Ionic Liquid Catalyst

Fabienne Fache; Ignasi de Azpiazu; Béatrice Pelotier; Olivier Piva; Christel Gozzi

doi:10.1055/s-0037-1612415

Synthesis, Inhaltsverzeichnis

Synthesis 2019; 51(11): 2430-2434
DOI: 10.1055/s-0037-1612415

paper

Green Access to α-Haloalkyl and α-Halobenzyl Esters, Versatile Intermediates for the One-Pot Two-Step Synthesis of O,O′-Diacyl Acetals Using Zinc-Based Ionic Liquid Catalyst

Fabienne Fache*

^aUniv Lyon, Université Claude Bernard Lyon 1, CNRS, INSA Lyon, CPE Lyon, ICBMS, UMR 5246, 69622 Villeurbanne Cedex, France eMail: fabienne.fache@univ-lyon1.fr

,

Ignasi de Azpiazu

^aUniv Lyon, Université Claude Bernard Lyon 1, CNRS, INSA Lyon, CPE Lyon, ICBMS, UMR 5246, 69622 Villeurbanne Cedex, France eMail: fabienne.fache@univ-lyon1.fr

,

Béatrice Pelotier

^aUniv Lyon, Université Claude Bernard Lyon 1, CNRS, INSA Lyon, CPE Lyon, ICBMS, UMR 5246, 69622 Villeurbanne Cedex, France eMail: fabienne.fache@univ-lyon1.fr

,

Olivier Piva

^aUniv Lyon, Université Claude Bernard Lyon 1, CNRS, INSA Lyon, CPE Lyon, ICBMS, UMR 5246, 69622 Villeurbanne Cedex, France eMail: fabienne.fache@univ-lyon1.fr

,

Christel Gozzi

^bCPE-Lyon, Campus Lyon Tech-La Doua, 43 bd du 11 novembre 1918, 69616 Villeurbanne, France

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Abstract

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Abstract

α-Haloalkyl and α-halobenzyl esters have been synthesized using a zinc-based ionic liquid catalyst, BMIZnCl₃. These esters can then react with acids without intermediate purification to obtain mixed O,O′-diacyl acetals in a one-pot process.

Key words

α-haloalkyl esters - α-halobenzyl esters - zinc - ionic liquids - prodrugs - O,O′-diacyl acetals

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Referenzen

References
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