FV HR2 Haplotype as Additional Inherited Risk Factor for Deep Vein Thrombosis in Individuals with a High-Risk Profile

Maurizio Margaglione; Anna Bossone; Donatella Coalizzo; Giovanna D’Andrea; Vincenzo Brancaccio; Antonio Ciampa; Elvira Grandone; Giovanni Di Minno

doi:10.1055/s-0037-1612939

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2002; 87(01): 32-36
DOI: 10.1055/s-0037-1612939

Review Article

Schattauer GmbH

FV HR2 Haplotype as Additional Inherited Risk Factor for Deep Vein Thrombosis in Individuals with a High-Risk Profile

Maurizio Margaglione

¹Unita’ di Aterosclerosi e Trombosi, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo

,

Anna Bossone

¹Unita’ di Aterosclerosi e Trombosi, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo

,

Donatella Coalizzo

¹Unita’ di Aterosclerosi e Trombosi, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo

,

Giovanna D’Andrea

¹Unita’ di Aterosclerosi e Trombosi, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo

,

Vincenzo Brancaccio

²Divisione di Ematologia, Unità di Coagulazione, Ospedale “A. Cardarelli”, Napoli

,

Antonio Ciampa

³Divisione di Ematologia, Ospedale “G. Moscati”, Avellino

,

Elvira Grandone

¹Unita’ di Aterosclerosi e Trombosi, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo

,

Giovanni Di Minno

⁴Istituto di Medicina Interna e Geriatria, Università di Palermo, Italy

› Author Affiliations

Abstract

Summary

A number of strongly linked polymorphisms within the Factor V gene (FV HR2 haplotype) has been identified as a cause of resistance to activated protein C, and has suggested a modest risk factor for vein thrombosis. We investigated the frequency of the HR2 haplotype in 433 consecutive patients with confirmed deep vein thrombosis and 326 controls. The HR2 haplotype was more frequent in patients (15.2%) than in controls (10.1%). The risk of thrombosis among carriers of this haplotype was significantly increased (odds ratio: 1.6 [95% CI: 1.0-2.5]). The estimated risk associated with the HR2 haplotype was 1.8 (95% CI: 1.1-2.9) in subjects with (n = 255), and 1.4 (95% CI: 0.8-2.4) in those without (n = 178) acquired risk factors for vein thrombosis. After adjustment for sex, FV Leiden and FII A²⁰²¹⁰ mutations, the estimated risk of vein thrombosis among carriers of the HR2 haplotype was 1.8 (95% CI: 1.1-2.8). Present data indicate that the HR2 haplotype is independently associated with vein thrombosis among individuals with a highrisk profile.

Keywords

HR2 haplotype - FV gene - inherited risk factors - vein thrombosis

Full Text

References

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