Thrombin Generation in a Reconstituted System: A Comment

H. Coenraad Hemker

doi:10.1055/s-0037-1613046

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2002; 87(03): 551-552
DOI: 10.1055/s-0037-1613046

Letters to the Editor

Schattauer GmbH

Thrombin Generation in a Reconstituted System: A Comment

H. Coenraad Hemker

¹Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands

› Author Affiliations

Abstract

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References

References
1 Butenas S, Branda RF, van’t Veer C, Cawthern KM, Mann KG. Platelets and phospholipids in tissue factor-initiated thrombin generation. Thromb Haemost 2001; 86: 660-7.
2 Cawthern KM, van’t Veer C, Lock JB, DiLorenzo ME, Branda RF, Mann KG. Blood coagulation in hemophilia A and hemophilia C. Blood 1998; 91: 4581-92.
3 Mann KG, van’t Veer C, Cawthern K, Butenas S. The role of the tissue factor pathway in initiation of coagulation. Blood Coagul Fibrinolysis 1998; 09 (Suppl. 01) S3-7.
4 Butenas S, van’t Veer C, Mann KG. “Normal” thrombin generation. Blood 1999; 94: 2169-78.
5 Butenas S, van’t Veer C, Cawthern K, Brummel KE, Mann KG. Models of blood coagulation. Blood Coagul Fibrinolysis 2000; 11 (Suppl. 01) S9-13.
6 Butenas S, Cawthern KM, van’t Veer C, DiLorenzo ME, Lock JB, Man KG. Antiplatelet agents in tissue factor-induced blood coagulation. Blood 2001; 97: 2314-22.
7 Beguin S, Lindhout T, Hemker HC. The effect of trace amounts of tissue factor on thrombin generation in platelet rich plasma, its inhibition by heparin. Thromb Haemost 1989; 61: 25-9.
8 Kessels H, Beguin S, Andree H, Hemker HC. Measurement of thrombin generation in whole blood-the effect of heparin and aspirin. Thromb Haemost 1994; 72: 78-83.
9 Prasa D, Svendsen L, Sturzebecher J. Inhibition of thrombin generation in plasma by inhibitors of factor Xa. Thromb Haemost 1997; 78: 1215-20.
10 Prasa D, Svendsen L, Sturzebecher J. The ability of thrombin inhibitors to reduce the thrombin activity generated in plasma on extrinsic and intrinsic activation. Thromb Haemost 1997; 77: 498-503.
11 Herault JP, Dol F, Gaich C, Bernat A, Herbert JM. Effect of clopidogrel on thrombin generatin in platelet-rich plasma in the rat. Thromb Haemost 1999; 81: 957-60.
12 Peyrou V, Lormeau JC, Herault JP, Gaich C, Pfliegger AM, Herbert JM. Contribution of erythrocytes to thrombin generation in whole blood. Thromb Haemost 1999; 81: 400-6.
13 Hemker HC, Beguin S. Phenotyping the clotting system. Thromb Haemost 2000; 84: 747-51.
14 Hemker HC, Willems GM, Beguin S. A computer assisted method to obtain the prothrombin activation velocity in whole plasma independent of thrombin decay processes. Thromb Haemost 1986; 56: 9-17.
15 Beguin S, Kessels H, Dol F, Hemker HC. The consumption of antithrombin III during coagulation, its consequences for the calculation of prothrombinase activity and the standardisation of heparin activity. Thromb Haemost 1992; 68: 136-42.
16 Conard J, Brosstad F, Lie MLarsen, Samama M, Abildgaard U. Molar antithrombin concentration in normal human plasma. Haemostasis 1983; 13: 363-8.
17 Rand MD, Lock JB, van’t Veer C, Gaffney DP, Mann KG. Blood clotting in minimally altered whole blood. Blood 1996; 88: 3432-45.
18 Nicolaes GA, Thomassen MC, Tans G, Rosing J, Hemker HC. Effect of activated protein C on thrombin generation and on the thrombin potential in plasma of normal and APC-resistant individuals. Blood Coagul Fibrinolysis 1997; 08: 28-38.
19 Smirnov MD, Ford DA, Esmon CT, Esmon NL. The effect of membrane composition on the hemostatic balance. Biochemistry 1999; 38: 3591-8.
20 Biggs R, Macfarlane RG. Human Blood Coagulation. Blackwell Scientific Publications; 1953: 97.
21 Reverter JC, Beguin S, Kessels H, Kumar R, Hemker HC, Coller BS. Inhibition of platelet-mediated, tissue factor-induced thrombin generation by the mouse/human chimeric 7E3 antibody. Potential implications for the effect of c7E3 Fab treatment on acute thrombosis and “clinical restenosis”. J Clin Invest 1996; 98: 863-74.
22 Beguin S, Kumar R, Keularts I, Seligsohn U, Coller BS, Hemker HC. Fibrin-dependent platelet procoagulant activity requires GPIb receptors and von Willebrand Factor. Blood 1999; 93: 64-70.
23 Eagle H. Studies on Blood Coagulation. I. The role of Prothrombin and of Platelets in the Formation of Thrombin. J Gen Physiol 1934; 18: 531-45.
24 Galli M, Beguin S, Lindhout T, Hemker CH. Inhibition of phospholipid and platelet-dependent prothrombinase activity in the plasma of patients with lupus anticoagulants. Br J Haematol 1989; 72: 549-55.