Thrombosis and Haemostasis, Table of Contents Thromb Haemost 2002; 88(02): 361-362DOI: 10.1055/s-0037-1613213 Letters to the Editor Schattauer GmbH Inhibition of Human Osteoblast Growth by Unfractionated Heparin and by Low Molecular Weight Heparins in vitro H. J. Kock 1 Division of Traumatology, Technical University of Munich, Germany , A. E. Handschin 2 Department of Surgery, University of Zurich, Switzerland › Author Affiliations Recommend Article Abstract Buy Article Abbreviations: LMWHs: Low molecular weight heparins, UFH: Unfractionated heparin Full Text References References 1 Griffith GC, Nichols jr G, Asher JD, Flanagan B. Heparin Osteoporosis. JAMA 1965; 193: 85-8. 2 Dahlman TC. Osteoporotic fractures and the recurrence of thromboembolism during pregnancy and the puerperium in 184 women undergoing thromboprophylaxis with heparin. Am J Obstet Gynaecol 1993; 168: 1265-70. 3 Monreal M, Lafoz E, Olive A, del-Rio L, Vedia C. Comparison of subcutaneous unfractionated heparin with a low molecular weight heparin in patients with venous thromboembolism and contraindications to coumarin. Thromb Haemost 1994; 71: 7-11. 4 Bhandari M, Hirsh J, Weitz JI, Young E, Venner TJ, Shaugnessy SG. The effects of standard and low molecular weight heparin on bone nodule formation in vitro. Thromb Haemost 1998; 80: 413-7. 5 Hurley MM, Kream BE, Raisz LG. Structural Determinants of Capacity of Heparin to Inhibit Collagen Synthesis in 21-Day Fetal Rat Calvaria. J Bone Miner Res 1990; 05: 1127-33. 6 Robey PG, Termine JD. Human bone cells in vitro. Calcif Tissue Int 1985; 37: 453-60. 7 Farley JR, Hall SL, Tanner MA, Wergedal JE. Specific activity of skeletal alkaline phosphatase in human osteoblast-line cells regulated by phosphatase, phosphatase esters and phosphatase analogies and release of alkaline phosphatase activity inversely regulated by calcium. J Bone Miner Res 1994; 09: 497-508. 8 Shaughnessy SG, Young E, Deschamps P, Hirsh J. The Effects of Low Molecular Weight and Standard Heparin on Calcium Loss from Fetal Rat Calvaria. Blood 1995; 86: 1368-73. 9 Fareed J, Jeske W, Hoppensteadt D, Clarizio R, Walenga JM. Are the available low molecular weight heparin-preparations the same?. Sem Thromb Hemost 1996; 22: 77-91. 10 Nelson-Piercy C. Hazards of heparin: allergy, heparin-induced thrombocytopenia and osteoporosis. Baillieres Clin Obstet Gynacol 1997; 11: 489-509. 11 Sivakumaran M, Gosh K, Zaidi Y, Hutchinson RM. Osteoporosis and vertebral collapse following low-dose low molecular weight heparin therapy in a young patient. Clin Lab Haematol 1996; 18: 55-7.
