Low Expression of Truncated Aα Chain Variant in Circulating Fibrinogen

Thromb Haemost 2002; 88(03): 533-534
DOI: 10.1055/s-0037-1613248

Letters to the Editor

Schattauer GmbH

Stephen O. Brennan

¹Molecular Pathology Laboratory, Canterbury Health Laboratories, Christchurch, New Zealand

,

Vivienne M. Homer

¹Molecular Pathology Laboratory, Canterbury Health Laboratories, Christchurch, New Zealand

,

Paul Ockelford

²Haematology Department, Auckland Hospital, Auckland, New Zealand

,

Peter M. George

¹Molecular Pathology Laboratory, Canterbury Health Laboratories, Christchurch, New Zealand

References
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3 Mullin J, Gorkun O, Lord S. Decreased lateral aggregation of a variant recombinant fibrinogen provides insights into the polymerisation mechanism. Biochemistry 2000; 9843-9.
4 Brennan SO. Electrospray ionisation analysis of human fibrinogen. Thromb Haemost 1997; 78: 1055-8.
5 Fellowes AP, Brennan SO, Stromorken H, Holme R, Brosstad F, George PM. Homozygous truncation of the fibrinogen Aα chain within the coiled coil causes congenital afibrinogenaemia. Blood 2000; 96: 773-5.
6 Gorkun OV, Veklich YI, Medved LV, Henchen AH, Weiel JW. Role of the αC domains of fibrin in clot formation. Biochemistry 1994; 33: 6986-97.