Diurnal Variation in PAI-1 Activity Predominantly Confined to the 4G-allele of the PAI-1 Gene

Tiny Hoekstra; Johanna M. Geleijnse; Evert G. Schouten; Cornelis Kluft

doi:10.1055/s-0037-1613304

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2002; 88(05): 794-798
DOI: 10.1055/s-0037-1613304

Review Article

Schattauer GmbH

Diurnal Variation in PAI-1 Activity Predominantly Confined to the 4G-allele of the PAI-1 Gene

Tiny Hoekstra

¹Division of Human Nutrition & Epidemiology, Wageningen University, Wageningen, The Netherlands

,

Johanna M. Geleijnse

¹Division of Human Nutrition & Epidemiology, Wageningen University, Wageningen, The Netherlands

,

Evert G. Schouten

¹Division of Human Nutrition & Epidemiology, Wageningen University, Wageningen, The Netherlands

,

Cornelis Kluft

²Gaubius Laboratory, TNO-PG, Leiden, The Netherlands

› Institutsangaben

Abstract

Summary

We examined the diurnal pattern in Plasminogen Activator Inhibitor-type 1 (PAI-1) activity and Plasminogen activator (t-PA) in relation to the 4G/5G-polymorphism in the promoter of the PAI-1 gene. The analyses were performed in the Arnhem Elderly Study, a populationbased study of 598 elderly. A single blood sample was drawn and the time of blood sampling was recorded (between 8 a. m. and 5.30 p. m.). Plasma PAI-1 activity was strongly associated with time of blood sampling, showing the highest values in the early morning. The diurnal pattern was clearly present in the 4G/4G (n = 184) and 4G/5G (n = 275) genotypes, but not in the 5G/5G-genotype (n = 139). T-PA antigen showed a weak diurnal variation, which did not differ across the variants of the 4G/5G-polymorphism. Our findings raise the hypothesis that 5G-homozygotic persons may be relatively protected from diurnal variation in the occurrence of coronary events.

Keywords

Fibrinolysis - diurnal variation - PAI-1 - t-PA - 4G/5G-polymorphism

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Referenzen

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