Quality of life (QOL) can be defined as the functional effect of an illness and its consequent therapy upon a patient, as perceived by the patient. Studies on the impact of chronic venous disease on quality of life are scarce compared to quality of life research in other diseases. The purpose of this paper was to describe instruments that assess the quality of life in patients with chronic venous disease and to review the literature on this topic.
A computer search of the MedLine database was performed to identify papers; the bibliographies of relevant articles were reviewed to obtain additional papers. Papers were included if they described the development or use of a quality of life instrument for patients with chronic venous disease.
A total of 25 papers were identified that fit the inclusion criteria. The studies described in the papers used six different generic instruments and ten disease-specific instruments. Quality of life in chronic venous disease was assessed in 12 studies. Six studies compared different types of treatment for chronic venous disease where QOL was an outcome measure. Despite the wide variety of measures used, results indicate that the quality of life of patients with chronic venous disease is affected in the physical domain mostly with regard to pain, physical functioning and mobility, and that they suffer from negative emotional reactions and social isolation.
We feel that QOL should be a standard measure in future studies in patients with chronic venous disease, preferably with a combination of generic and disease-specific measures.
Keywords
Review -
venous disease -
quality of life -
medical psychology
References
1
Schipper H,
Clinch J,
Powell V.
Definitions and conceptual issues. Quality of life Asessments in Clinical Trials. Spilker, ed. Raven Press 1990; 11-24.
3
Berzon RA.
Understanding and using health-related quality of life instruments within clinical research studies. Quality of Life Assessment in Clinical Trials: Method and Practice. Staquet, Hays, Fayers, eds: Oxford University Press 1998; 3-15.
10
Garratt A,
Schmidt L,
Mackintosh A.
et al. Quality of life measurement: bibliographic study of patient assessed health outcome measures. BMJ 2002; 324: 1417-21.
11
Kahn SR,
Hirsch A,
Shrier I.
Effect of post-thrombotic syndrome on health-related quality of life after deep venous thrombosis. Arch Intern Med 2002; 162: 1144-8.
15
Kurz X,
Lamping DL,
Kahn SR.
et al. Do varicose veins affect quality of life? Results of an international population-based study. J Vasc Surg 2001; 34: 641-8.
16
O&Brien B,
Levine M,
Willan A.
et al. Economic evaluation of outpatient treatment with low-molecular-weight heparin for proximal vein thrombosis. Arch Intern Med 1999; 159: 2298-2304.
17
Koopman MM,
Prandoni P,
Piovella F.
et al. Treatment of venous thrombosis with intrave-nous unfractionated heparin administered in the hospital as compared with subcutaneous low-molecular-weight heparin administered at home. The Tasman Study Group. N Engl J Med 1996; 334: 682-7.
21
Franks PJ,
Moffatt CJ.
Health related quality of life in patients with venous ulceration: use of the Nottingham Health Profile. Qual Life Res 2001; 10: 693-700.
22
Lindholm C,
Bjellerup M,
Christensen OB.
et al. Quality of life in chronic leg ulcer patients. An assessment according to the Nottingham Health Profile. Acta Derm Venereol 1993; 73: 440-3.
28
Franks PJ,
Wright DD,
Fletcher AE.
et al. A questionnaire to assess risk factors, quality of life, and use of health resources in patients with venous disease. Eur J Surg 1992; 158: 149-55.
29
Wood-Dauphinee S.
Assessing quality of life in clinical research: from where have we come and where are we going?. J Clin Epidemiol 1999; 52: 355-63.
30
Augustin M,
Dieterle W,
Zschocke I.
et al. Development and validation of a disease-specific questionnaire on the quality of life of patients with chronic venous insufficiency. VASA 1997; 26: 291-301.
31
Klyscz T,
Junger M,
Schanz S.
et al. Quality of life in chronic venous insufficiency (CVI). Results of a study with the newly developed Tübingen Questionnaire for measuring quality of life of patients with chronic venous insufficiency]
. Hautarzt 1998; 49: 372-81.
32
Lamping DL,
Abenhaim L,
Kurz X.
et al. Measuring quality of life and symptoms in chronic venous disorders of the leg: development and psychometric evaluation of the VEINES-QOL/VEINES-SYM questionnaire. Qual Life Res 1998; 7: 621-2.
33
Lamping DL,
Schroter S,
Kurz X.
et al. Evaluation of outcomes in chronic venous disorders of the leg: development of a scientifically rigorous, patient-reported measure of symptoms and quality of life. J Vasc Surg 2003; 37: 410-9.
34
Launois R,
Raboul-Marty J,
Henry B.
Construction and validation of a quality of life questionnaire in Chronic Lower Limb Venous Insufficiency (CIVIQ). Qual Life Res 1996; 5: 539-54.
35
Mathias SD,
Prebil LA,
Putterman CG.
et al. A health-related Quality of Life Measure in patients with deep vein thrombosis: a validation study. Drug Inform J 1999; 33: 1173-87.
37
Ziegler S,
Schillinger M,
Maca TH.
et al. Post-thrombotic syndrome after primary event of deep venous thrombosis 10 to 20 years ago. Thromb Res 2001; 101: 23-33.
39
Phillips T,
Stanton B,
Provan A.
et al. A study of the impact of leg ulcers on quality of life: financial, social, and psychologic implications. J Am Acad Dermatol 1994; 31: 49-53.
40
Frank D,
Blattler W.
Comparison of ambulatory and inpatient treatment of acute deep venous thrombosis of the leg: subjective and economic aspects. Schweiz Med Wochenschr 1998; 128: 1328-33.
42
Kulinna W,
Ney D,
Wenzel T.
et al. The effect of self-monitoring the INR on quality of anticoagulation and quality of life. Semin Thromb Hemost 1999; 25: 123-6.
