Reply to: Factor XII levels, factor XII 46 C>T polymorphism and venous thrombosis: a word of caution is needed

• References

• 1 Antonio G, Sartori MT, Lombardi AM, Pellati D. Factor XII levels, factor XII 46 C>T polymorphism and venous thrombosis: a word of caution is needed. Thromb Haemost 2004; 92: 892-3.
• 2 Rosendaal FR, Reitsma PH. Genetic studies in complex disease. J Thromb Haemost 2004; 02: 342.
• 3 Soria JM, Almasy L, Souto JC. et al. A quantitative trait locus in human factor XII gene jointly influence plasma factor XII levels and susceptibility to thrombotic disease. Am J Hum Genet 2002; 70: 567-74.
• 4 Santamaria A, Mateo J, Tirado I. et al. Homozygosity of the T allele of the 46 C-kT polymorphism in the F12 gene is a risk factor for ischemic stroke in the Spanish population. Stroke. 2004 Jul 1 [Epub ahead of print] (in press)
• 5 Santamaria A, Martinez-Rubio A, Mateo J. et al. Homozygosity of the T allele of the 46 C →T polymorphism in the F12 gene is a risk factor for acute coronary artery disease in the Spanish population. Haematologica. 2004 (in press)
• 6 Elston CR. Linkage and Assocaition. Genet Epidemiol 1998; 15: 565-76.
• 7 Lane DA, Grant PJ. Role of hemostatic gene polymorphisms in venous and arterial thrombosis. Blood 2000; 95: 1517-32.
• 8 Tirado I, Soria JM, Mateo J. et al. Association after linkage analysis indicates that homozygosity for the 46C>T polymorphism in the F12 gene is a genetic risk factor for venous thrombosis. Thromb Haemost 2004; 91: 899-904.
• 9 Souto JC, Almasy L, Borrell M. et al. Genetic susceptibility to thrombosis and its relationship to physiological risk factors: the GAIT study. Am J Hum Genet 2000; 67: 1452-9.
• 10 Heit JA, Phelps MA, Ward SA. et al. Familial segregation of venous thromboembolism. J Thromb Haemost 2004; 02: 731-6.