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Thromb Haemost 1998; 79(01): 150-154
DOI: 10.1055/s-0037-1614235
Review Article
Schattauer GmbH

Presence of Two Plasminogen Alleles in Normal Populations

Masafumi Kida
1   The Department of Molecular Pathological Biochemistry, Yamagata University School of Medicine, Yamagata, Japan
,
Masuyo H.- Kawabata
2   The Department of Biochemistry, University of Washington, Seattle, WA, USA
,
Tomio Yamazaki
1   The Department of Molecular Pathological Biochemistry, Yamagata University School of Medicine, Yamagata, Japan
,
Akitada Ichinose
1   The Department of Molecular Pathological Biochemistry, Yamagata University School of Medicine, Yamagata, Japan
2   The Department of Biochemistry, University of Washington, Seattle, WA, USA
› Author Affiliations
Further Information

Publication History

Received 28 January 1997

Accepted after resubmission 09 September 1997

Publication Date:
08 December 2017 (online)

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Summary

When we compared nucleotide sequences of the 5’-flanking regions for plasminogen genes from 11 individuals, six substitutions were identified even among normal subjects. A new haplotype (termed allele II) was screened by PCR-RFLP analysis among 54 Japanese and 58 Caucasian normal subjects. The frequency of allele II was 0.787 in the Japanese and 0.560 in the Caucasians, indicating that the ratio of alleles differs between populations. Examination of 118 cases with dysplasminogenemia revealed that the Ala601-Thr mutation was present on allele I in most cases. This mutation was also associated with allele II in one-fourth of all cases, suggesting possible recombination within the plasminogen gene. Interestingly, we previously demonstrated that the expression activity of allele II was about 1.8 fold that of allele I in vitro.

 

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