Download PDF
Thromb Haemost 1999; 82(03): 1198-1199
DOI: 10.1055/s-0037-1614354
Letters to the Editor
Schattauer GmbH

A Novel Factor V Null Mutation at Arg 506 Causes a False Positive Factor V Leiden Result

Oksana Mirochnik
1   From the Department of Haematology, Westmead Hospital, Sydney, Australia
,
Natasha Halim-Kertanegara
1   From the Department of Haematology, Westmead Hospital, Sydney, Australia
,
Anthony J. Henniker
1   From the Department of Haematology, Westmead Hospital, Sydney, Australia
,
Emmanuel J. Favaloro
1   From the Department of Haematology, Westmead Hospital, Sydney, Australia
,
Campbell R. Tiley
2   Central Coast Area Pathology, Gosford Hospital, Gosford, Australia
,
Mark S. Hertzberg
1   From the Department of Haematology, Westmead Hospital, Sydney, Australia
,
David A. McDonald
1   From the Department of Haematology, Westmead Hospital, Sydney, Australia
› Author Affiliations
Further Information

Publication History

Received 15 April 1999

Accepted 19 April 1999

Publication Date:
09 December 2017 (online)

Also available at
    Permissions and Reprints

 

 

  • References

  • 1 Bertina RM, Koeleman BPC, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, van der Velden PA, Reitsma PH. Mutation in blood coagulation Factor V associated with resistance to activated protein C. Nature 1994; 369: 64-7.
    CrossrefPubMedSearch in Google Scholar
  • 2 Margaglione M, D’Andrea G, Capucci G, Grandone E, Giuliani N, Colaizzo G, Vecchione G, Di Minno G. Detection of the Factor V Leiden using SSCP. Thromb Haemost 1996; 76: 814-5.
    Thieme ConnectPubMedSearch in Google Scholar
  • 3 Lunghi B, Castoldi E, Mingozzi F, Bernardi F, Castaman G. A novel Factor V null mutation detected in a thrombophilic patient with pseudo-homozygous APC resistance and in an asymptomatic unrelated subject. Blood 1998; 92: 1463-4.
    PubMedSearch in Google Scholar
  • 4 Guasch JF, Lensen RPM, Bertina RM. Molecular characterization of a type 1 quantitative Factor V deficiency in a thrombosis patient that is “pseudo-homozygous” for activated protein C resistance. Thromb Haemost 1997; 77: 252-7.
    Thieme ConnectPubMedSearch in Google Scholar