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Thromb Haemost 1999; 81(04): 511-515
DOI: 10.1055/s-0037-1614515
Rapid Communication
Schattauer GmbH

Prevalence of Three Common Polymorphisms in the A-subunit Gene of Factor XIII in Patients with Coronary Artery Disease

Association with FXIII Activity and Antigen Levels
H.P. Kohler
1   From the Unit of Molecular Vascular Medicine, Leeds General Infirmary, University of Leeds, Leeds, UK
,
T.S. Futers
1   From the Unit of Molecular Vascular Medicine, Leeds General Infirmary, University of Leeds, Leeds, UK
,
P.J. Grant
1   From the Unit of Molecular Vascular Medicine, Leeds General Infirmary, University of Leeds, Leeds, UK
› Author Affiliations
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Publication History

Received 16 July 1998

Accepted after resubmission 16 December 1998

Publication Date:
09 December 2017 (online)

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Summary

Activated blood coagulation factor XIII has an important role in the final stage of the clotting cascade by the covalent crosslinking of α- and γ-fibrin chains. We have recently shown that a functional polymorphism in exon 2, codon 34 of the FXIII A-subunit gene is protective against myocardial infarction. To investigate the prevalence of three other common point mutations in the A-subunit gene (codon 564, C to T, 650 G to A and 651 G to C) and their association with FXIII activity and antigen levels, 275 patients with coronary artery disease and 196 controls were studied. There was no difference in the prevalence of the polymorphisms between patients and controls or between patients with or without MI. Only genotype at codon 564 was associated with FXIII activity with lower activities in subjects possessing the T allele. There was evidence of linkage disequilibrium between codon 34 and codon 564. These results suggest that FXIIIVal34Leu is the only common polymorphism in the coding region of the A-subunit gene of FXIII associated with coronary artery disease.

 

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