Elevated High Molecular Weight Fibrinogen in Plasma Is Predictive of Coronary Ischemic Events after Acute Myocardial Infarction

Edelmiro Reganon; Virtudes Vila; Fernando Ferrando; Vicenta Martínez-Sales; Laura Fayos; Miguel Ruano; Justo Aznar

doi:10.1055/s-0037-1614844

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1999; 82(05): 1403-1405
DOI: 10.1055/s-0037-1614844

Rapid Communications

Schattauer GmbH

Elevated High Molecular Weight Fibrinogen in Plasma Is Predictive of Coronary Ischemic Events after Acute Myocardial Infarction

Edelmiro Reganon

¹From the Research Center, Coronary Care Unit and Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain

,

Virtudes Vila

¹From the Research Center, Coronary Care Unit and Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain

,

Fernando Ferrando

¹From the Research Center, Coronary Care Unit and Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain

,

Vicenta Martínez-Sales

¹From the Research Center, Coronary Care Unit and Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain

,

Laura Fayos

²Coronary Care Unit and Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain

,

Miguel Ruano

²Coronary Care Unit and Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain

,

Justo Aznar

³Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain

› Institutsangaben

Abstract

Summary

This study investigates the association between the concentration and function of plasma fibrinogen molecules measured at the time of hospital admission in patients with acute myocardial infarction (AMI), with reference to the risk of new coronary ischemic events during a three-day follow-up period of. Before starting fibrinolytic and anticoagulant treatment plasma fibrinogen, high molecular weight fibrinogen (HMW-fibrinogen), fibrin formation rate (FbFR) and phosphorous content in fibrinogen were determined in 90 AMI patients. During a three-day follow-up period 12 patients suffered new ischemic events. The 12 patients with coronary ischemia had higher concentrations of plasma fibrinogen (312 ± 23 vs. 270 ± 73 mg/dl, p <0.05) and HMW-fibrinogen (246 ± 35 vs. 189 ± 23 mg/dl, p <0.001) and a higher FbFR (65 ± 30 vs. 40 ± 25, p <0.001) than patients without these events. No association was found between the phosphorous content in fibrinogen and new coronary ischemic events. We conclude that after myocardial infarction an elevated plasma level of HMW-fibrinogen and a high FbFR value at the time of hospital admission are associated with new coronary ischemic events during a three-day follow-up period.

Keywords

Fibrinogen - HMW-fibrinogen - fibrin - myocardial infarction - coronary ischemic events

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Referenzen

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