Polymorphism of the Platelet Glycoprotein IIIa Gene in Patients with Coronary Stenosis

Miguel Garcia-Ribes; Domingo Gonzalez-Lamuño; Rafael Hernandez-Estefania; Thierry Colman; Miguel Pocovi; Miguel Delgado-Rodriguez; Miguel Garcia-Fuentes; Jose M. Revuelta

doi:10.1055/s-0037-1615028

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1998; 79(06): 1126-1129
DOI: 10.1055/s-0037-1615028

Rapid Communication

Schattauer GmbH

Polymorphism of the Platelet Glycoprotein IIIa Gene in Patients with Coronary Stenosis

Miguel Garcia-Ribes

¹From the Nutrition and Cardiovascular Risk Unit, Spain

,

Domingo Gonzalez-Lamuño

¹From the Nutrition and Cardiovascular Risk Unit, Spain

,

Rafael Hernandez-Estefania

¹From the Nutrition and Cardiovascular Risk Unit, Spain

,

Thierry Colman

³Hemodynamics Unit, Santander, Spain

,

Miguel Pocovi

⁵Dept. of Biochemistry and Molecular Biology, University of Zaragoza, Spain

,

Miguel Delgado-Rodriguez

²Division of Preventive Medicine and Public Health, University of Cantabria, Spain

,

Miguel Garcia-Fuentes

¹From the Nutrition and Cardiovascular Risk Unit, Spain

,

Jose M. Revuelta

¹From the Nutrition and Cardiovascular Risk Unit, Spain

⁴Division of Cardiovascular Surgery, Hospital Universitario Marques de Valdecilla, Santander, Spain

› Author Affiliations

Abstract

Summary

Based on genetic variability, structural differences in the glycoprotein IIb/IIIa platelet receptor for adhesive proteins result in individual differences in the thrombogenicity of platelets. Recent studies suggest a controversial association between a genetic polymorphism of the glycoprotein IIIa gene (Pl^A2) and the risk of coronary artery disease. In our study, the prevalence of the Pl^A2 allele in a group of patients undergoing percutaneous coronary revascularization was 37%, a value significantly higher than in controls [13%, odds ratio (OR) = 3.93, 95% CI, 1.84 to 8.53] suggesting a significant association between this polymorphism and documented coronary stenosis, which is strongest among <60 years old patients (OR = 12.30, 95% CI, 2.98 to 70.93). This polymorphism represents an inherited risk factor for severe cardiovascular disease due to coronary occlusion.

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References

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