FVIII Coagulant Activity and Antigen in Subjects with Ischaemic Heart Disease

Gillian I. Rice; Peter J. Grant

doi:10.1055/s-0037-1615354

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1998; 80(05): 757-762
DOI: 10.1055/s-0037-1615354

Review Article

Schattauer GmbH

FVIII Coagulant Activity and Antigen in Subjects with Ischaemic Heart Disease

Gillian I. Rice

¹From the Unit of Molecular Vascular Medicine, Division of Medicine, School of Medicine, University of Leeds, UK

,

Peter J. Grant

¹From the Unit of Molecular Vascular Medicine, Division of Medicine, School of Medicine, University of Leeds, UK

› Author Affiliations

Abstract

Summary

Raised factor VIII coagulant activity has been associated with Ischaemic Heart Disease and Myocardial Infarction (MI). We measured FVIII:C and FVIII:Ag levels in 288 white European patients characterised for extent of atheroma by coronary angiography and for a history of MI by WHO criteria, and 313 white European healthy controls. FVIII:Ag levels were higher in patients than controls after adjustment for confounding variables (1.17 IU/ml patients, 1.03 IU/ml controls [p <0.0005]), whereas FVIII:C levels were lower in patients (1.26 IU/ml patients, 1.45 IU/ml controls [p < 0.0005]). FVIII:Ag levels were higher in patients with MI and with angiographic evidence of atheroma than controls. FVIII:Ag levels but not FVIII:C levels were a significant independent risk factor for MI in multivariate analysis (Odds Ratio 2.40 [1.35-4.27] [p = 0.003]). No association of FVIII:Ag or FVIII:C levels and presence or extent of atheroma was found in multivariate analysis. In conclusion, this study found an independent association of FVIII:Ag but not FVIII:C with MI.

Full Text

References

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