Conventional Fibrinolytic Assays for the Evaluation of Patients with Venous Thrombosis: Don’t Bother

Kenneth A. Bauer

doi:10.1055/s-0037-1615592

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2001; 85(03): 377-378
DOI: 10.1055/s-0037-1615592

Commentary

Schattauer GmbH

Conventional Fibrinolytic Assays for the Evaluation of Patients with Venous Thrombosis: Don’t Bother

Kenneth A. Bauer

¹Hematology Section, VA Boston Healthcare System and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

› Institutsangaben

Abstract

Summary

Hypofibrinolysis, as defined by an absent or deficient increase in blood or plasma fibrinolytic activity after an appropriate stimulus, has been known to be present in patients following an episode of deep venous thrombosis for over 30 years. The usual stimulus is 10 min of venous occlusion using a blood pressure cuff inflated to a pressure midway between systolic and diastolic pressures. The early screening fibrinolytic assays were relatively insensitive in detecting fibrinolytic system hypofunction and lacked standardization.

Supported in part by the Medical Research Service of the Department of Veterans Affairs.

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Referenzen

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