Diverse Roles of Macrophage Matrix Metalloproteinases in Tissue Destruction and Tumor Growth

Steven D. Shapiro

doi:10.1055/s-0037-1615921

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1999; 82(02): 846-849
DOI: 10.1055/s-0037-1615921

Research Article

Schattauer GmbH

Diverse Roles of Macrophage Matrix Metalloproteinases in Tissue Destruction and Tumor Growth

Steven D. Shapiro

¹Departments of Pediatrics, Medicine, and Cell Biology and Physiology, Washington University School of Medicine at Barnes-Jewish Hospital, St. Louis, MO, USA

› Author Affiliations

Abstract

Summary

In the mouse, macrophage elastase is critical to macrophage proteolysis. The use of gene-targeting has uncovered both pathological roles, including destructive effects in aneurysm formation and emphysema, and physiological roles, such as tumor growth inhibition and regulation of inflammation. Translation of findings from mouse to human biology depends upon how well the disease models replicate the human conditions and the similarity of enzyme profile between species. We know that human MMP-12 is associated with these diseases, but as opposed to the mouse, other MMPs may also be of importance (MMP-9, and perhaps MMP-7, in particular). Our interpretation is that findings in mice reflect the critical role of macrophage proteolysis in these disease processes.

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References

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