The Role of Factor XI in Thrombin Generation Induced by Low Concentrations of Tissue Factor

Irene M. L. W. Keularts; Ariella Zivelin; Uri Seligsohn; H. Coenraad Hemker; Suzette Béguin

doi:10.1055/s-0037-1615964

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2001; 85(06): 1060-1065
DOI: 10.1055/s-0037-1615964

Review Article

Schattauer GmbH

The Role of Factor XI in Thrombin Generation Induced by Low Concentrations of Tissue Factor

Irene M. L. W. Keularts

¹Department of Biochemistry, University of Maastricht, Maastricht, The Netherlands

,

Ariella Zivelin

²Institute of Thrombosis and Hemostasis, Department of Hematology, Chaim Sheba Medical Center, Tel-Hashomer and Sackler School of Medicine, Tel-Aviv University, Israel

,

Uri Seligsohn

²Institute of Thrombosis and Hemostasis, Department of Hematology, Chaim Sheba Medical Center, Tel-Hashomer and Sackler School of Medicine, Tel-Aviv University, Israel

,

H. Coenraad Hemker

¹Department of Biochemistry, University of Maastricht, Maastricht, The Netherlands

,

Suzette Béguin

¹Department of Biochemistry, University of Maastricht, Maastricht, The Netherlands

› Author Affiliations

Abstract

Summary

Thrombin generation has been studied in the plasma of severely factor XI deficient patients under conditions in which contact activation did not play a role. In platelet-rich as well as platelet-poor plasma, thrombin generation was dependent upon the presence of factor XI at tissue factor concentrations of between 1 and 20 pg/ml i.e. ~ 0.01 to 0.20% of the concentration normally present in the thromboplastin time determination. The requirement for factor XI is low; significant thrombin generation was seen at 1% factor XI; at 10%, thrombin formation was nearly normalised. A suspension of normal platelets in severely factor XI deficient plasma did not increase thrombin generation. This implies that there is no significant factor XI activity carried by normal platelets, although the presence of factor XI and factor XI inhibitors in platelets cannot be ruled out.

Key words

Factor XI - thrombin generation - platelet procoagulant activity - tissue factor

Full Text

References

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