Thrombophilic Risk Factors in Patients with Central Retinal Vein Occlusion

Rossella Marcucci; Laura Bertini; Betti Giusti; Tamara Brunelli; Sandra Fedi; Anna Paola Cellai; Daniela Poli; Guglielmina Pepe; Rosanna Abbate; Domenico Prisco

doi:10.1055/s-0037-1616130

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2001; 86(03): 722-726
DOI: 10.1055/s-0037-1616130

Review Articles

Schattauer GmbH

Thrombophilic Risk Factors in Patients with Central Retinal Vein Occlusion

Rossella Marcucci

¹Dept. Area Critica Medico-Chirurgica, Thrombosis Center, Az. Ospedaliera Careggi, University of Florence, Italy

,

Laura Bertini

¹Dept. Area Critica Medico-Chirurgica, Thrombosis Center, Az. Ospedaliera Careggi, University of Florence, Italy

,

Betti Giusti

¹Dept. Area Critica Medico-Chirurgica, Thrombosis Center, Az. Ospedaliera Careggi, University of Florence, Italy

,

Tamara Brunelli

¹Dept. Area Critica Medico-Chirurgica, Thrombosis Center, Az. Ospedaliera Careggi, University of Florence, Italy

,

Sandra Fedi

¹Dept. Area Critica Medico-Chirurgica, Thrombosis Center, Az. Ospedaliera Careggi, University of Florence, Italy

,

Anna Paola Cellai

¹Dept. Area Critica Medico-Chirurgica, Thrombosis Center, Az. Ospedaliera Careggi, University of Florence, Italy

,

Daniela Poli

¹Dept. Area Critica Medico-Chirurgica, Thrombosis Center, Az. Ospedaliera Careggi, University of Florence, Italy

,

Guglielmina Pepe

¹Dept. Area Critica Medico-Chirurgica, Thrombosis Center, Az. Ospedaliera Careggi, University of Florence, Italy

,

Rosanna Abbate

¹Dept. Area Critica Medico-Chirurgica, Thrombosis Center, Az. Ospedaliera Careggi, University of Florence, Italy

,

Domenico Prisco

¹Dept. Area Critica Medico-Chirurgica, Thrombosis Center, Az. Ospedaliera Careggi, University of Florence, Italy

› Institutsangaben

Abstract

Summary

Few and contrasting data are available on the prevalence of hemostatic risk factors in patients with central retinal vein occlusion (CRVO). Aim of this study was to investigate the metabolic and inherited risk factors for venous thrombosis in 100 CRVO patients (age: 59 yrs; range 18-77) and in 100 controls (age: 56 yrs; range 18-84). In patients homocysteine (Hcy) levels were significantly higher than in controls and were affected by the C677T methylenetetrahydrofolate reductase (MTHFR) polymorphism (p <0.001). The prevalences of activated protein C resistance (APCR), factor V Leiden positivity, elevated PAI-1 and Lp(a) levels were significantly higher in patients with respect to controls. At multivariate analysis, only hyperhomocysteinemia (OR 11, 95% CI 3.6-36.2; p <0.0001) and elevated PAI-1 levels (OR 8.9, 95% CI 3.5-41.3; p <0.01), in addition to hypertension (OR 40.5, 95% CI 8.6-188.8; p <0.00001) and hypercholesterolemia (OR 3.1, 95% CI 1.6-20.5; p <0.05), were independent risk factors for CRVO. These data demonstrate a potential role of hemostatic risk factors in the pathophysiology of CRVO.

Keywords

Central retinal vein occlusion - homocysteine - genetic polymorphisms - fibrinolysis - risk factors

Volltext

Referenzen

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