The Vascular Biology of the Glycoprotein Ib-IX-V Complex

Michael C. Berndt; Yang Shen; Sacha M. Dopheide; Elizabeth E. Gardiner; Robert K. Andrews

doi:10.1055/s-0037-1616216

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2001; 86(01): 178-188
DOI: 10.1055/s-0037-1616216

Research Article

Schattauer GmbH

The Vascular Biology of the Glycoprotein Ib-IX-V Complex

Michael C. Berndt

¹Hazel and Pip Appel Vascular Biology Laboratory, Baker Medical Research Institute, Prahran, Australia

,

Yang Shen

¹Hazel and Pip Appel Vascular Biology Laboratory, Baker Medical Research Institute, Prahran, Australia

,

Sacha M. Dopheide

²Department of Medicine, Australian Centre for Blood Diseases, Monash Medical School, Box Hill, Victoria, Australia

,

Elizabeth E. Gardiner

¹Hazel and Pip Appel Vascular Biology Laboratory, Baker Medical Research Institute, Prahran, Australia

,

Robert K. Andrews

¹Hazel and Pip Appel Vascular Biology Laboratory, Baker Medical Research Institute, Prahran, Australia

› Author Affiliations

Abstract

Summary

It has long been recognized that binding of von Willebrand factor (vWf) by the platelet membrane glycoprotein (GP) Ib-IX-V complex initiates the cascade of events leading to thrombosis and haemostasis. In the last several years, however, it has become apparent that the GP Ib-IX-V complex plays a much broader role in vascular biology, a recognition in part due to the identification of novel adhesive ligands for GP Ib-IX-V such as P-selectin and Mac-1. Binding of vWf by the GP Ib-IX-V complex is also important in formation of the developing thrombus. Platelets can utilize the GP Ib-IX-V complex and PSGL-1 to roll on activated endothelium via surface-expressed endothelial P-selectin. The GP Ib-IX-V complex can bind the I domain of Mac-1, a binding interaction potentially relevant to transmigration of macrophages through mural thrombus, a process required for vessel remodeling post angioplasty. This review will focus on recent advances in our understanding of the structure and function of this important platelet receptor, with particular emphasis on insights made within the last two years.

Key words

GP Ib-IX-V complex - von Willebrand factor - thrombosis - platelet activation - signalling

Full Text

References

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