Nervenheilkunde, Table of Contents Nervenheilkunde 2016; 35(10): 658-663DOI: 10.1055/s-0037-1616434 Update Schattauer GmbH Update Epilepsie Update epilepsy B. J. Steinhoff 1 Epilepsiezentrum Kork, Kehl-Kork › Author Affiliations Recommend Article Abstract Full Text PDF Download Schlüsselwörter SchlüsselwörterEpilepsie - Klassifikation - Diagnostik - Therapie - Update Keywords KeywordsEpilepsy - classification - diagnostics - therapy - update References Literatur 1 Commission on Classification and Terminology of the International League against Epilepsy. Proposal for revised clinical and electroencephalographic classification of epileptic seizures. Epilepsia 1981; 22: 498-501. 2 Commission on Classification and Terminology of the International League against Epilepsy. Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia 1989; 30: 389-99. 3 Engel J. A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology. Epilepsia 2001; 42: 796-803. 4 Engel J. Report of the ILAE Classification Core Group. Epilepsia 2006; 47: 1558-1568. 5 Steinhoff B, Krämer G. Revidierte Terminologie und neue Konzepte zur Einteilung von epileptischen Anfällen und Epilepsien. Neue Empfehlungen. Muss das wirklich sein?. Z Epileptol 2010; 23: 225-226. 6 Blume WT. et al. Glossary of descriptive terminology for ictal semiology: report of the ILAE Task Force on Classification and Terminology. Epilepsia 2001; 42: 1212-1218. 7 Berg AT. et al. Revides terminology and concepts for organization of seizures and epilepsies: Report of the ILAE Commission on Classification and Terminology, 2005–2009. Epilepsia 2010; 51: 676-685. 8 Lüders HO, Turnbull J, Kaffashi F. Are the dichotomies generalized versus focal epilepsies and idiopathic versus symptomatic epilepsies still valid in modern epileptology?. Epilepsia 2009; 50: 1336-43. 9 Wellmer J. et al. Proposal for a magnetic resonance imaging protocol for the detection of epileptogenic lesions at early outpatient stages. Epilepsia 2013; 54: 1977-1987. 10 Von Oertzen J. et al. Standard magnetic resonance imaging is inadequate for patients with refractory focal epilepsy. J Neurol Neurosurg Psychiatry 2002; 73: 643-647. 11 Steinhoff BJ. et al. The impact of guidelines on the quality of MRI diagnostics in adult patients referred to a tertiary Epilepsy Centre. J Neurol 2013; 260: 2174-2175. 12 Steinhoff BJ. Antikonvulsive Pharmakotherapie Jugendlicher und Erwachsener. State of the art. Z Epileptol 2013; 26: 142-153. 13 Schmidt D. Pharmacotherapy of epilepsy – current problems and controversies. Fortschr Neurol Psychiat 1983; 51: 363-86. 14 Schmidt D. Drug treatment of epilepsy: Options and limitations. Epilepsy Behav 2009; 15: 56-65. 15 Baumgartner C. et al. Erster epileptischer Anfall und Epilepsien im Erwachsenenalter. In: Diener HC, Weimar C, Berlit P. et al. (Hrsg) Leitlinien für Diagnostik und Therapie in der Neurologie. Stuttgart: Thieme; 2012: 28-47 16 Steinhoff BJ, Kurth C, Dennig D. Levetiracetam bei generalisierten Epilepsien des Erwachsenenalters. Praktische Erfahrungen mit dem Einsatz außerhalb der Zulassung. Z Epileptol 2012; 25: 118-24. 17 Tomson T. et al. Valproate in the treatment of epilepsy in girls and women of childbearing potential. Epilepsia 2015; 56: 1006-1019. 18 Baker G. et al. IQ at 6 years after in utero exposure to antiepileptic drugs: a controlled cohort study. Neurology 2015; 84: 382-390. 19 Steinhoff BJ. Der Epilepsiepatient in der Praxis. Basel: ComMed Verlagsagentur; 2005 20 Callaghan BC, Anand K, Hesdorffer D, Hauser WA, French JA. Likelihood of seizure remission in an adult population with refractory epilepsy. Ann Neurol 2007; 62 (04) 382-9. 21 Luciano AL, Shorvon SD. Results of treatment changes in patients with apparently drug-resistant chronic epilepsy. Ann Neurol 2007; 62 (04) 375-81. 22 Steinhoff BJ, Staack AM, Wisniewski I. Seizure control with antiepileptic drug therapy in 517 consecutive adult outpatients at the Kork Epilepsy Centre. Epileptic Disord 2012; 14: 379-387. 23 Rosenow F. et al. The LaLiMo trial: lamotrigine compared with levetircatem in the initial 26 weeks of monotherapy for focal and generalised epilepsy – an open-label, prospective, randomised controlled multicenter Study. J Neurol Neurosurg Psychiatry 2012; 83: 1093-8. 24 Trinka E. et al. KOMET: an unblinded, randomised, two parallel-group, stratified trial comparing the effectiveness of levetiracetam with controlled-release carbamazepine and extended-release sodium valproate as monotherapy in patients with newly diagnosed epilepsy. J Neurol Neurosurg Psychiatry 2013; 84: 1138-1147. 25 Privitera MD. et al. Topiramate, carbamazepine and valproate monotherapy: double-blind comparison in newly diagnosed epilepsy. Acta Neurol Scand 2003; 107: 165-175. 26 Steinhoff BJ. et al. The LAM-SAFE Study: Lamotrigine versus carbamazepine or valproic acid in newly diagnosed focal and generalized epilepsies in adolescents and adults. Seizure 2005; 14: 597-605. 27 Rowan AJ. et al. New onset geriatric epilepsy: a randomized study of gabapentin, lamotrigine and carbamazepine. Neurology 2005; 64: 1868-1873. 28 Ficker DM. et al. Improved tolerability and efficacy in epilepsy patients with extended-release carbamazepine. Neurology 2005; 65: 593-5. 29 Saetre E. et al. An international multicenter randomized double-blind controlled trial of lamotrigine and sustained-release carbamazepine in the treatment of newly diagnosed epilepsy in the elderly. Epilepsia 2007; 48: 1292-1302. 30 Werhahn K. et al. A randomized, double-blind comparison of antiepileptic drug treatment in the elderly with new-onset focal epilepsy. Epilepsia 2015; 56: 450-459. 31 Doeser A. et al. Targeting pharmacoresistant epilepsy and epileptogenesis with a dual-purpose antiepileptic drug. Brain 2015; 138: 371-387. 32 Klitgaard H. et al. Brivaracetam: Rationale for discovery and preclinical profile of a selective SV2A ligand for epilepsy treatment. Epilepsia 2016; 57: 538-548. 33 Doty P. et al. Development of lacosamide for the treatment of partial-onset seizures. Ann N Y Acad Sci 2013; 1291: 56-68. 34 Faulkner MA, Burke RA. Safety profile of two novel antiepileptic agents approved for the treatment of refractory partial seizures: ezogabine (retigabine) and perampanel. Expert Opin Drug Saf 2013; 12: 847-855. 35 Nass RD. et al. Adjunctive retigabine in refractory focal epilepsy: Postmarketing experience at four tertiary epilepsy care centers in Germany. Epilepsy Behav 2016; 56: 54-58. 36 Correia FD. et al. Two-year follow-up with eslicarbazepine acetate: a consecutive, retrospective, observational study. Epilepsy Res 2014; 108: 1399-1405. 37 Villanueva V. et al. Long-term safety and efficacy of eslicarbazepine acetate in patients with focal seizures: results of the 1-year ESLIBASE retrospective study. Epilepsy Res 2014; 108: 1243-1252. 38 Runge U. et al. A noninterventional study evaluating the effectiveness and safety of lacosamide added to monotherapy in patients with epilepsy with partial-onset seizures in daily clinical practice: The VITOBA study. Epilepsia 2015; 56: 1921-1930. 39 Trinka E, Steinhoff BJ, Nikanorova M, Brodie MJ. Perampanel for focal epilepsy: insights from early clinical experience. Acta Neurol Scand 2016; 133: 160-172. 40 Bauer S. et al. Transcutaneous vagus nerve stimulation (tVNS) for treatment of drug-resistant epilepsy: A randomized, double-blind clinical trial (cMPsE02). Brain Stimul. 2016 EPUB ahead of print 41 Soss J. et al. A prospective long-term study of external trigeminal stimulation for drug-resistant epilepsy. Epilepsy Behav 2015; 42: 44-47.