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Hamostaseologie 2006; 26(01): 27-37
DOI: 10.1055/s-0037-1616873
Original article
Schattauer GmbH

Hämostaseologische Globalteste

Global tests of haemostasis
M. Spannagl
1   Klinikum der Universität München-Innenstadt, Klinikum Rechts der Isar der TU München
,
G. Moessmer
1   Klinikum der Universität München-Innenstadt, Klinikum Rechts der Isar der TU München
› Author Affiliations
Further Information

Publication History

Publication Date:
26 December 2017 (online)

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Zusammenfassung

Hämostaseologische Globalteste messen eine Reihe von Reaktionsschritten im physiologischen Ablauf der Gerinnselbildung . Als Konsequenz stellt die ursprüngliche Plasma- oder Vollblutprobe einen beträchtlichen Volumenanteil im endgültigen Testansatz dar. Entsprechend hoch ist der Einfluss von Störfaktoren und anderen Faktoren (Medikation oder Komorbidität). Die genaue Beachtung der präanalytischen Bedingungen ist deswegen von außerordentlicher Bedeutung. Abgesehen von der standardisierten Ergebnismitteilung der Thromboplastinzeit in INR, sind die Messergebnisse zwischen verschiedenen Reagenzien wegen fehlender Standardisierung etwa der aPTT oder Thrombinzeit nicht vergleichbar. Bei der Interpretation der Ergebnisse müssen die vielfältigen Einfluss- und Störfaktoren berücksichtigt werden. Nur eine aus der klinischen Ausgangssituation präzise entwickelte Fragestellung wird zu relevanten Ergebnissen führen.

Summary

Global tests of haemostasis represent several reaction steps in the physiologic process of clotting. The proportion of plasma or whole blood in the test mixture of a global test is significantly higher than in clotting factor tests. Accordingly, the influence of preanalytical variables is strong, e.g. underlying diseases or drug effects. Strict adherence to preanalytical requirements is of utmost importance. Apart form the standardized reporting of the thromboplastin time (prothrombin time) as International Normalized Ratio (INR), results are generally not comparable when generated by using different reagents or instrumentation. Multiple potential influencing factors have to be considered when interpreting the results. Only laboratory requests precisely derived from the clinical situation can yield clinically relevant conclusions.

Schlüsselwörter

Hämostaseologische Globalteste - Präanalytik - Plasma - Vollblut - Prädiktivität

Keywords

Global tests of haemostasis - preanalytical aspects - plasma - whole blood - predictive value
 

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