Tissue-Faktor im akuten Koronarsyndrom

B. A. Steppich; I. Ott

doi:10.1055/s-0037-1616883

Hämostaseologie, Table of Contents

Hamostaseologie 2006; 26(02): 147-153
DOI: 10.1055/s-0037-1616883

Original article

Schattauer GmbH

Tissue-Faktor im akuten Koronarsyndrom

Tissue factor in acute coronary syndromes

B. A. Steppich

¹Deutsches Herzzentrum München der Technischen Universität München

,

I. Ott

¹Deutsches Herzzentrum München der Technischen Universität München

› Author Affiliations

Abstract

Zusammenfassung

Die Ruptur einer arteriosklerotischen Plaque mit nachfolgender Thrombusbildung und Gewebsischämie stellt das führende pathophysiologische Korrelat des akuten Koronarsyndroms dar. Gewebsthromboplastin oder Tissue-Faktor (TF) als wichtigster physiologischer Initiator der extrinsischen Gerinnungskaskade nimmt eine zentrale Rolle in der Pathogenese des akuten Koronarsyndroms ein. Das Ausmaß des thrombotischen Prozesses wird zum einen durch den Gehalt an lokalem, vaskulären TF des rupturierten Plaques zum anderen durch zirkulierenden TF moduliert. Neben seiner gut charakterisierten Bedeutung bei der Atherothrombose ist TF darüber hinaus über eine Aktivierung von Signaltransduktionskaskaden an entzündlichen Prozessen sowie am vaskulären Remodeling beteiligt. Der vorliegende Artikel zeigt die gegenwärtige Vorstellung über die Beteiligung von TF beim akuten Koronarsyndrom auf und diskutiert mögliche Konsequenzen und therapeutische Ansatzpunkte.

Summary

Rupture of an atherosclerotic plaque with subsequent thrombosis and myocardial ischemia is the pathopysiological mechanism in acute coronary syndromes. Tissue factor (TF) as the main initiator of the extrinsic coagulation cascade plays a central role in the pathogenesis of acute coronary syndromes. The extent of the thrombotic process is modulated by local vascular TF of the ruptured plaque as well as by circulating TF. In addition, TF alters signaling pathways and, thereby, contributes to inflammatory reactions and vascular remodeling. This review adresses current concepts of the role of TF in acute coronary syndromes and discusses potential consequences and therapeutic approaches.

Schlüsselwörter

Tissue-Faktor - akutes Koronarsyndrom - Blutgerinnung

Keywords

Tissue factor - acute coronary syndrome - coagulation

Full Text

References

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