Ionic Competition and 67Ga in Vivo Accumulation

L. J. Anghileri; P. Thuvenot; F. Brunotte; C. Marchai; J. Robert

doi:10.1055/s-0037-1620562

Nuklearmedizin - NuclearMedicine, Table of Contents

Nuklearmedizin 1982; 21(03): 114-116
DOI: 10.1055/s-0037-1620562

Originalarbeiten – Original Articles

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Ionic Competition and ⁶⁷Ga in Vivo Accumulation

Ionenkompetition und Speicherung von ⁶⁷Ga in Vivo

L. J. Anghileri

¹From the Nuclear Medicine Service and Biophysics Laboratory, Faculty of Medicine B, University of Nancy, France

,

P. Thuvenot

¹From the Nuclear Medicine Service and Biophysics Laboratory, Faculty of Medicine B, University of Nancy, France

,

F. Brunotte

¹From the Nuclear Medicine Service and Biophysics Laboratory, Faculty of Medicine B, University of Nancy, France

,

C. Marchai

¹From the Nuclear Medicine Service and Biophysics Laboratory, Faculty of Medicine B, University of Nancy, France

,

J. Robert

¹From the Nuclear Medicine Service and Biophysics Laboratory, Faculty of Medicine B, University of Nancy, France

› Author Affiliations

Abstract

Es wurde die Wirkung verschiedener Zitrate trivalenter Kationen auf die ⁶⁷Ga-Zitrat-Speicherung von Tumortieren untersucht. Eine Beziehung zwischen der Ionengröße des gleichzeitig injizierten Kations und der Hemmung der ⁶⁷Ga-Speicherung weist darauf hin, daß die Eigenschaften des Kations (Ionenradius und elektrische Ladung) die wichtigste Rolle in der Speicherung der Radioaktivität spielen. Die offenbare Übereinstimmung dieses Phänomens mit der Hypothese des isomorphen Ersatzes wird diskutiert.

The effect of several citrates of trivalent cations on ⁶⁷Ga citrate uptake by tumor-bearing animals has been studied. A relationship between the ionic size of the simultaneously injected cation and the ⁶⁷Ga uptake inhibition indicates that the cation characteristics (ionic radius and electrical charge) seem to play the most important role in this radioactivity accumulation. The apparent agreement of this phenomenon with the isomorphous replacement hypothesis is discussed.

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References

References
1 Anghileri L. J, Heidbreder M. On the mechanism of accumulation of ⁶⁷Ga by tumors. Oncology 34: 74-77 1977;
2 Anghileri L. J, Thouvenot P, Brunotte F, Marchai C, Robert J. In vitro and in vivo effects of ferric citrate on ⁶⁷Ga citrate uptake by DS sarcoma tumors. To be published in Europ. J. Nucl. Med
3 Clausen J, Edeling C.-J, Fogh J. ⁶⁷Ga binding to human serum proteins and tumor components. Cancer Res 34: 1931-1937 1974;
4 Gunasekera S. W, King L. J, Lavender P. J. The behavior of tracer gallium-67 towards serum proteins. Clin, chim. Acta 39: 401-406 1972;
5 Hara T. On the binding of gallium to transferrin. Int. J. Nucl. Med. Biol 1: 152-154 1974;
6 Hartman R. E, Hayes R. L. Gallium binding by blood serum. (Abstr.). Fed. Proc 1967; 26: 780
7 Hegge F. N, Mahler D. J, Larson S. M. The incorporation of ⁶⁷Ga into the ferritin fraction of rabbit hepatocytes in vivo. J. nucl. Med 18: 937-939 1977;
8 Hoffer P. Gallium: Mechanisms. J. nucl. Med 21: 282-285 1980;
9 Pauling L. In The Nature of Chemical Bond Cornell Univ. Press; Ithaca, N. Y.: 1960
10 Samezina K, Sakamura K, Orii H. The role of ferritin in the in vivo localization of ⁶⁷Ga. In. J. nucl. Med. Biol 8: 94-95 1981;
11 Williams R. J. P. In: Bioinorganic Chemistry Adv. Chem. Series, American Chemical Society; Washington, D. C: 1971