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Nuklearmedizin 1977; 16(02): 68-70
DOI: 10.1055/s-0037-1620608
Originalarbeiten – Original Articles
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Plasma Renin Activity in Patients with Ischaemic Heart Disease[*]

J. Urbánek
1   From the Institute of Biophysics and Nuclear Medicine and IVth Department of Internal Medicine Faculty of General Medicine Charles University Prague, Department of Internal Medicine, and the Research Institute for Endocrinology Prague, CSSR
,
O. Hofman
1   From the Institute of Biophysics and Nuclear Medicine and IVth Department of Internal Medicine Faculty of General Medicine Charles University Prague, Department of Internal Medicine, and the Research Institute for Endocrinology Prague, CSSR
,
R. Reisenauer
1   From the Institute of Biophysics and Nuclear Medicine and IVth Department of Internal Medicine Faculty of General Medicine Charles University Prague, Department of Internal Medicine, and the Research Institute for Endocrinology Prague, CSSR
,
A. Slaby
1   From the Institute of Biophysics and Nuclear Medicine and IVth Department of Internal Medicine Faculty of General Medicine Charles University Prague, Department of Internal Medicine, and the Research Institute for Endocrinology Prague, CSSR
› Author Affiliations
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Publication History

Received:09 July 1976

Publication Date:
10 January 2018 (online)

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Summary

Plasma renin activity (PRA) stimulated by upright posture was measured in 300 men aged 45 - 64 years using a radioimmunoassay of angiotensin-I. The examined subjects were normotensive or patients with benign essential hypertension and were divided into 6 groups according to the absence of manifest atherosclerosis, the presence of definite angina pectoris or a history of myocardial infarction. Each group contained 50 unselected subjects, with a comparable mean age. Significant differences in mean PRA were found between corresponding groups of hypertensives and normotensives, the values in hypertensives being lower. The percentage of low renin values was higher in hypertensives with ischaemic heart disease than in other groups. It is suggested that this finding might be explained by functional disturbances in the kidneys in hypertensives with ischaemic heart disease.

* Dedicated to the 50th birthday anniversary of Prof. MUDr. Z. Dienstbier, DrSc, Prague.


 

  • References

  • 1 Brown J.J, Lever A.F, Robertson J.I.S, Schalekamp M.A. Renal abnormality of essential hypertension. Lancet 1974; II: 320
    PubMedSearch in Google Scholar
  • 2 Brunner H.R, Laragh J.H, Baer L, Newton M.A, Goodwin F.T, Krakoff L.R, Bard R.H, Bühler F.R. Essential hypertension: Renin and aldosterone, heart attack and stroke. New Engl. J. Med 1972; 286: 441
    CrossrefPubMedSearch in Google Scholar
  • 3 Brunner H.R, Sealey J.E, Laragh J.H. Renin as a risk factor in essential hypertension: More evidence. Amer. J. Med 1973; 55: 295
    CrossrefPubMedSearch in Google Scholar
  • 4 Constantinides P, Robinson M. Ultrastructural injury of arterial endothelium. II. Effects of vasoactive amines. Arch. Path 1969; 88: 106
    PubMedSearch in Google Scholar
  • 5 Haber E, Koerner T, Page L.B, Kliman B, Purnode A. Application of a radioimmunoassay of angiotensin I to the physiologic measurements of plasma renin activity in normal human subjects. J. clin. Endocrin 1969; 29: 1349
    CrossrefPubMedSearch in Google Scholar
  • 6 Hollenberg N.K, Epstein M, Basch R.I, Couch N.P, Hickler R.B, Merrill J.P. Renin secretion in exxential and accelerated hypertension. Amer. J. Med 1969; 47: 855
    CrossrefPubMedSearch in Google Scholar
  • 7 Kaplan N.M. The prognostic implications of plasma renin in essential hypertension. J. Amer. med. Ass 1975; 231: 167
    CrossrefSearch in Google Scholar
  • 8 Robertson A.L, Khairallah P.A. Effects of angiotensin II and some analogues on vascular permeability in the rabbit. Circulat. Res 1972; 31: 923
    CrossrefPubMedSearch in Google Scholar
  • 9 Rose G.A, Blackburn H. Cardiovascular survey methods. Wld Hlth Org. Monogr. Ser 1968; 56: 188
    Search in Google Scholar
  • 10 Slaby A, Reisenauer R, Reiniš Z.Z.. Arterial blood pressure and the manifestation of atherosclerosis in a rural population of North Bohemia. Atherosclerosis 1971; 14: 79
    CrossrefPubMedSearch in Google Scholar
  • 11 Slabý A, Hofmann O, Urbánek J, Reisenauer R. To the question of prognostic significance of plasma renin activity: Mean values in normotensive and hypertensive men with ischaemic heart disease (in Czech., summary in English) Cas. Lék. čes 1974; 113: 1330
    Search in Google Scholar
  • 12 Slabý A, Hofman O, Urbánek J, Reisenauer R. Plasma renin activity and the ischaemic heart disease, (in Czech., summary in English) Čas. Lék. čes 1975; 114: 1325
    Search in Google Scholar