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Phlebologie 2015; 44(06): 334-337
DOI: 10.1055/s-0037-1621484
Review Article
Schattauer GmbH

Gerbstoffhaltiger Extrakt zur oralen und topischen Behandlung bei CVI und Hämorrhoidalleiden

Article in several languages: English | deutsch
P. Rohdewald
1   Institut für Pharmazeutische Chemie, Westfälische-Wilhelms-Universität, Münster, Germany
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Publication History

Received: 24 July 2015

Accepted after Revision: 08 October 2015

Publication Date:
05 January 2018 (online)

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Zusammenfassung

Die vorliegende Literaturübersicht fasst Untersuchungen zu den biologischen und klinischen Wirkungen eines Extraktes aus der Rinde der französischen Meereskiefer (Pycnogenol®) bei der chronischen Veneninsuffizienz (CVI) zusammen.

Ursachen der anti-ödematösen und anti-thrombotischen Wirkungen sind die Verbesserung der Endothelfunktion, die Hemmung der Permeabilität der Kapillarwände und der Thrombozytenaggregation. Des Weiteren trägt die anti-inflammatorische und anti-oxidative Wirkung zur beschleunigten Heilung von Ulzera und Hämorrhoidalleiden nach oraler und kutaner Anwendung von Pycnogenol® bei. Die Hemmung der Ödeme der unteren Gliedmaßen und der Entstehung von tiefen Thrombosen wurde auch bei Passagieren von Langstreckenflügen nachgewiesen. In vergleichenden Untersuchungen konnte die Überlegenheit von Pycnogenol® gegenüber einigen Venotonika und der Anwendung von medizinischen Kompressionsstrümpfen gezeigt werden. Milde, unerwünschte Wirkungen traten bei etwa 1 % der Fälle auf.

Schlüsselwörter

Pycnogenol® - Ödeme - Ulzera - Thrombosen - CVI - Hämorrhoidalleiden
 

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