Download PDF
Osteologie 2017; 26(02): 67-73
DOI: 10.1055/s-0037-1622089
Knochenmarködemsyndrom
Schattauer GmbH

Knochenmarködemsyndrome

Ein LiteraturüberblickBone marrow edema syndromesA literature review
J. Fürmetz
1   Klinik für Allgemeine, Unfall- und Wiederherstellungschirurgie, Klinikum der Universität München LMU, München, Deutschland
,
M. Schieker
1   Klinik für Allgemeine, Unfall- und Wiederherstellungschirurgie, Klinikum der Universität München LMU, München, Deutschland
2   Novartis Insititutes for Biomedical Research (NIBR), Basel, Schweiz
,
W. Böcker
1   Klinik für Allgemeine, Unfall- und Wiederherstellungschirurgie, Klinikum der Universität München LMU, München, Deutschland
› Author Affiliations
Further Information

Publication History

eingereicht: 10 April 2017

angenommen: 25 April 2017

Publication Date:
02 January 2018 (online)

Also available at
    Permissions and Reprints

Zusammenfassung

Seit 1959 die ersten Fälle einer transienten Osteoporose beschrieben wurden, gibt es eine Vielzahl an Literaturberichten über das Knochenmarködemsyndrom (KMÖS). Trotz der immer besseren Bildtechnologien bleibt die richtige Diagnosestellung bei Vorliegen eines Knochenmarködems immer noch eine Herausforderung. Eine regionale radiologische Knochendichteminderung zusammen mit einem Knochenmarködem kann bei mehreren KMÖS, wie z. B. der transienten Osteo- porose oder der “regional migratory osteoporosis”, beobachtet werden. Zudem ähneln sich die Erkrankungen in der klinischen Beschwerdesymptomatik mit selbstlimitierendem Verlauf. Jedoch ist die Differenzierung zu anderen aggressiven Erkrankungen mit möglichen Langzeitfolgen für eine korrekte Therapie essenziell. Der Pathomechanismus dieser Erkrankungen ist weiterhin ungeklärt und ist genauso wie verschiedene Therapieformen Gegenstand aktueller Studien.

Summary

After the first description of transient osteoporosis in 1959 many research has been published on bone marrow edema syndromes. Correct diagnosis in case of bone marrow edema still remains challenging, although imaging technologies are constantly improving. A regional osteoporosis together with bone marrow edema exists in bone marrow edema syndromes like the transient osteoporosis or the regional migratory osteoporosis. Additionally these entities are similar in clinical symptoms and self limiting. Differential diagnosis to other more aggressive conditions is essential. Pathomechanism and therapy of bone marrow edema syndromes are topics of current studies.

Schlüsselwörter

Knochenmarködemsyndrom - transiente Osteoporose

Keywords

Bone marrow edema - transient osteoporosis
 

  • Literatur

  • 1 Wilson AJ, Murphy WA, Hardy DC, Totty WG. Transient osteoporosis: transient bone marrow edema?. Radiology 1988; 167 (03) 757-760.
    CrossrefPubMedGoogle Scholar
  • 2 Patel S. Primary bone marrow oedema syndromes. Rheumatology [Internet] 2014 May 1 [cited 2017 Mar 30] 53 (05) 785-792 Available from: https://academic.oup.com/rheumatology/articlelookup/doi/10.1093/rheumatology/ket324
    Google Scholar
  • 3 Hamer OW, Kriegsmann J. Knochenmarködem in der Magnetresonanztomographie: Ein irreführender Begriff?. Z Für Rheumatol [Internet] 2012 Jan [cited 2017 Mar 30]; 71 (01) 12-16 Available from: http://link.springer.com/10.1007/s00393–011–0937–9.
    Google Scholar
  • 4 Freyschmidt J. [Bone (marrow) edema in magnetic resonance imaging – finding or only signal? A brief look behind the mirror]. Z Rheumatol 2012; 71 (01) 8-11.
    CrossrefPubMedGoogle Scholar
  • 5 Graf BK, Cook DA, De Smet AA, Keene JS. “Bone bruises” on magnetic resonance imaging evaluation of anterior cruciate ligament injuries. Am J Sports Med 1993; 21 (02) 220-223.
    CrossrefPubMedGoogle Scholar
  • 6 Lynch TC, Crues JV, Morgan FW. et al. Bone abnormalities of the knee: prevalence and significance at MR imaging. Radiology 1989; 171 (03) 761-776.
    CrossrefPubMedGoogle Scholar
  • 7 Mink JH, Deutsch AL. Occult cartilage and bone injuries of the knee: detection, classification, and assessment with MR imaging. Radiology 1989; 170 (3 Pt 1): 823-829.
    CrossrefPubMedGoogle Scholar
  • 8 Thiryayi WA, Thiryayi SA, Freemont AJ. Histopathological perspective on bone marrow oedema, reactive bone change and haemorrhage. Eur J Radiol 2008; 67 (01) 62-67.
    CrossrefPubMedGoogle Scholar
  • 9 Punwar S, Hall-Craggs M, Haddad FS. Bone bruises: definition, classification and significance. Br J Hosp Med Lond Engl 2007; 68 (03) 148-151.
    Google Scholar
  • 10 Felson DT, Chaisson CE, Hill CL. et al. The association of bone marrow lesions with pain in knee osteoarthritis. Ann Intern Med 2001; 134 (07) 541-549.
    CrossrefPubMedGoogle Scholar
  • 11 Craiovan BS, Baier C, Grifka J. et al. Das Knochenmarködemsyndrom (KMÖS). Orthop [Internet] 2013 Mar [cited 2017 Mar 30]; 42 (03) 191-204 Available from: http://link.springer.com/10.1007/s00132–012–2053–1 .
    Google Scholar
  • 12 Berger CE, Kröner AH, Minai-Pour MB. et al. Biochemical markers of bone metabolism in bone marrow edema syndrome of the hip. Bone 2003; 33 (03) 346-351.
    CrossrefPubMedGoogle Scholar
  • 13 Trevisan C, Ortolani S, Monteleone M, Marinoni EC. Regional migratory osteoporosis: a pathogenetic hypothesis based on three cases and a review of the literature. Clin Rheumatol 2002; 21 (05) 418-425.
    CrossrefPubMedGoogle Scholar
  • 14 Kim YM, Oh HC, Kim HJ. The pattern of bone marrow oedema on MRI in osteonecrosis of the femoral head. J Bone Joint Surg Br 2000; 82 (06) 837-841.
    CrossrefPubMedGoogle Scholar
  • 15 Calvo E, Fernandez-Yruegas D, Alvarez L. Core decompression shortens the duration of pain in bone marrow oedema syndrome. Int Orthop 2000; 24 (02) 88-91.
    CrossrefPubMedGoogle Scholar
  • 16 Krause R, Glas K, Schulz A, Gradinger R. [The transitory bone marrow edema syndrome of the hip]. Z Orthop Ihre Grenzgeb 2002; 140 (03) 286-296.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 17 Plenk H, Hofmann S, Eschberger J. et al. Histomorphology and bone morphometry of the bone marrow edema syndrome of the hip. Clin Orthop 1997; Jan (334) 73-84.
    PubMedGoogle Scholar
  • 18 Rosen RA. Transitory demineralization of the femoral head. Radiology 1970; 94 (03) 509-512.
    CrossrefPubMedGoogle Scholar
  • 19 Solomon L. Bone-marrow oedema syndrome. J Bone Joint Surg Br 1993; 75 (02) 175-176.
    PubMedGoogle Scholar
  • 20 Korompilias AV, Karantanas AH, Lykissas MG, Beris AE. Bone marrow edema syndrome. Skeletal Radiol 2009; 38 (05) 425-436.
    CrossrefPubMedGoogle Scholar
  • 21 Frost HM. The regional acceleratory phenomenon: a review. Henry Ford Hosp Med J 1983; 31 (01) 3-9.
    PubMedGoogle Scholar
  • 22 Noorda RJ, van der Aa JP, Wuisman PI. et al. Transient osteoporosis and osteogenesis imperfecta. A case report. Clin Orthop 1997; 337: 249-255.
    CrossrefPubMedGoogle Scholar
  • 23 Starr AM, Wessely MA, Albastaki U. et al. Bone marrow edema: pathophysiology, differential diagnosis, and imaging. Acta Radiol Stockh Swed 1987; 49 (07) 771-786.
    Google Scholar
  • 24 Curtiss PH, Kincaid WE. Transitory demineralization of the hip in pregnancy. A report of three cases. J Bone Joint Surg Am 1959; 41-A: 1327-1333.
    CrossrefPubMedGoogle Scholar
  • 25 Keys GW, Walters J. Idiopathic transient osteoporosis of the hip: brief report. J Bone Joint Surg Br 1987; 69 (05) 773-774.
    CrossrefPubMedGoogle Scholar
  • 26 Shifrin LZ, Reis ND, Zinman H, Besser MI. Idiopathic transient osteoporosis of the hip. J Bone Joint Surg Br 1987; 69 (05) 769-773.
    PubMedGoogle Scholar
  • 27 Swezey RL. Transient osteoporosis of the hip, foot and knee. Arthritis Rheum 1970; 13 (06) 858-868.
    CrossrefPubMedGoogle Scholar
  • 28 Aigner N, Meizer R, Meraner D. et al. Tapping test in patients with painful bone marrow edema of the knee. Clin J Pain 2008; 24 (02) 131-134.
    CrossrefPubMedGoogle Scholar
  • 29 Horas K, Fraissler L, Maier G. et al. High Prevalence of Vitamin D Deficiency in Patients With Bone Marrow Edema Syndrome of the Foot and Ankle. Foot Ankle Int. 2017 Mar 1; 1071100717697427.
    PubMedGoogle Scholar
  • 30 Aigner N, Meizer R, Meraner D. et al. Bone marrow edema syndrome in postpartal women: treatment with iloprost. Orthop Clin North Am 2009; 40 (02) 241-247.
    CrossrefPubMedGoogle Scholar
  • 31 Lakhanpal S, Ginsburg WW, Luthra HS, Hunder GG. Transient regional osteoporosis. A study of 56 cases and review of the literature. Ann Intern Med 1987; 106 (03) 444-450.
    CrossrefPubMedGoogle Scholar
  • 32 Duncan H, Frame B, Frost H, Arnstein AR. Regional migratory osteoporosis. South Med J 1969; 62 (01) 41-44.
    CrossrefPubMedGoogle Scholar
  • 33 Doury P. Bone-marrow oedema, transient osteoporosis, and algodystrophy. J Bone Joint Surg Br 1994; 76 (06) 993-994.
    CrossrefPubMedGoogle Scholar
  • 34 Malizos KN, Zibis AH, Dailiana Z. et al. MR imaging findings in transient osteoporosis of the hip. Eur J Radiol 2004; 50 (03) 238-244.
    CrossrefPubMedGoogle Scholar
  • 35 Karantanas AH, Drakonaki E, Karachalios T. et al. Acute non-traumatic marrow edema syndrome in the knee: MRI findings at presentation, correlation with spinal DEXA and outcome. Eur J Radiol 2008; 67 (01) 22-33.
    CrossrefPubMedGoogle Scholar
  • 36 Assouline-Dayan Y, Chang C, Greenspan A. et al. Pathogenesis and natural history of osteonecrosis. Semin Arthritis Rheum 2002; 32 (02) 94-124.
    CrossrefPubMedGoogle Scholar
  • 37 Mitchell DG, Rao VM, Dalinka MK. et al. Femoral head avascular necrosis: correlation of MR imaging, radiographic staging, radionuclide imaging, and clinical findings. Radiology 1987; 162 (03) 709-715.
    CrossrefPubMedGoogle Scholar
  • 38 Hofmann S, Kramer J, Breitenseher M. et al. [Bone marrow edema in the knee. Differential diagnosis and therapeutic possibilities]. Orthopade 2006; 35 (04) 463-475 quiz 476–477.
    CrossrefPubMedGoogle Scholar
  • 39 Fayad LM, Kamel IR, Kawamoto S. et al. Distinguishing stress fractures from pathologic fractures: a multimodality approach. Skeletal Radiol 2005; 34 (05) 245-259.
    CrossrefPubMedGoogle Scholar
  • 40 Simon MJK, Barvencik F, Luttke M. et al. Intravenous bisphosphonates and vitamin D in the treatment of bone marrow oedema in professional athletes. Injury 2014; 45 (06) 981-987.
    CrossrefPubMedGoogle Scholar
  • 41 Costa-Paz M, Muscolo DL, Ayerza M. et al. Magnetic resonance imaging follow-up study of bone bruises associated with anterior cruciate ligament ruptures. Arthrosc J Arthrosc Relat Surg Off Publ Arthrosc Assoc N Am Int Arthrosc Assoc 2001; 17 (05) 445-449.
    CrossrefPubMedGoogle Scholar
  • 42 Roemer FW, Bohndorf K. Long-term osseous sequelae after acute trauma of the knee joint evaluated by MRI. Skeletal Radiol 2002; 31 (11) 615-623.
    CrossrefPubMedGoogle Scholar
  • 43 Zanetti M, Bruder E, Romero J, Hodler J. Bone marrow edema pattern in osteoarthritic knees: correlation between MR imaging and histologic findings. Radiology 2000; 215 (03) 835-840.
    CrossrefPubMedGoogle Scholar
  • 44 Manara M, Varenna M. A clinical overview of bone marrow edema. Reumatismo 2014; 66 (02) 184-196.
    CrossrefPubMedGoogle Scholar
  • 45 Nakamura N, Horibe S, Nakamura S, Mitsuoka T. Subchondral microfracture of the knee without osteonecrosis after arthroscopic medial meniscectomy. Arthrosc J Arthrosc Relat Surg Off Publ Arthrosc Assoc N Am Int Arthrosc Assoc 2002; 18 (05) 538-541.
    CrossrefPubMedGoogle Scholar
  • 46 James SLJ, Panicek DM, Davies AM. Bone marrow oedema associated with benign and malignant bone tumours. Eur J Radiol 2008; 67 (01) 11-21.
    CrossrefPubMedGoogle Scholar
  • 47 Holt MA, Keene JS, Graf BK, Helwig DC. Treatment of osteitis pubis in athletes. Results of corticosteroid injections. Am J Sports Med 1995; 23 (05) 601-606.
    CrossrefPubMedGoogle Scholar
  • 48 Aigner N, Petje G, Schneider W. et al. Juvenile bone-marrow oedema of the acetabulum treated by iloprost. J Bone Joint Surg Br 2002; 84 (07) 1050-1052.
    CrossrefPubMedGoogle Scholar
  • 49 Capone A, Podda D, Ennas F. et al. Hyperbaric oxygen therapy for transient bone marrow oedema syndrome of the hip. Hip Int J Clin Exp Res Hip Pathol Ther 2011; 21 (02) 211-216.
    Google Scholar
  • 50 Gao F, Sun W, Li Z. et al. Extracorporeal shock wave therapy in the treatment of primary bone marrow edema syndrome of the knee: a prospective randomised controlled study. BMC Musculoskelet Disord 2015; 16: 379.
    CrossrefPubMedGoogle Scholar
  • 51 Schöberl M, Prantl L, Loose O. et al. Non-surgical treatment of pubic overload and groin pain in amateur football players: a prospective doubleblinded randomised controlled study. Knee Surg Sports Traumatol Arthrosc Off J ESSKA 2017 Jan 16..
    Google Scholar
  • 52 Beckmann J, Schmidt T, Schaumburger J. et al. Infusion, core decompression, or infusion following core decompression in the treatment of bone edema syndrome and early avascular osteonecrosis of the femoral head. Rheumatol Int 2013; 33 (06) 1561-1565.
    CrossrefPubMedGoogle Scholar