Download PDF
Tierarztl Prax Ausg K Kleintiere Heimtiere 2003; 31(06): 377-382
DOI: 10.1055/s-0037-1622374
Heim-/Zootiere
Schattauer GmbH

Generalisierte spontane Kryptokokkose bei einem Meerschweinchen

Ein FallberichtSpontaneous disseminated cryptococcosis in a guinea pig
Kristin Brandes
1   Aus dem Institut für Tierpathologie, Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie (Vorstand: Prof. Dr. W. Hermanns)
,
B. Stierstorfer
2   Institut für Tierpathologie, Lehrstuhl für Allgemeine Pathologie und Neuropathologie (Vorstand: Prof. Dr. W. Schmahl)
,
C. Werckenthin
3   Institut für Medizinische Mikrobiologie, Infektions- und Seuchenmedizin (Vorstand: Prof. Dr. O.-R. Kaaden) der Ludwig-Maximilians-Universität München
,
W. Hermanns
1   Aus dem Institut für Tierpathologie, Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie (Vorstand: Prof. Dr. W. Hermanns)
› Author Affiliations
Further Information

Publication History

Publication Date:
05 January 2018 (online)

Also available at
    Permissions and Reprints

Zusammenfassung

Bei Störungen des Allgemeinbefindens, die insbesondere mit respiratorischen und neurologischen Symptomen einhergehen, sind bei allen Spezies auch Systemmykosen in Betracht zu ziehen. In dem vorliegenden Fallbericht wird eine generalisierte Infektion mit Cryptococcus neoformans bei einem Meerschweinchen vorgestellt. Diese in der Tiermedizin eher selten beschriebene Infektionskrankheit hat in der Humanmedizin mit der Verbreitung des humanen Immundefizienzvirus und den konsekutiven opportunistischen Infektionen an Bedeutung zugenommen.

Summary

Clinical manifestation of respiratory or neurological symptoms is not pathognomonic for systemic mycosis but has to be taken into consideration in all species. In the present report a case of disseminated infection with Cryptococcus neoformans in a guinea pig is described. Although a rare event in veterinary medicine, this mycosis has gained importance in human patients as an opportunistic infection associated with the spread of the human immunodeficiency virus infections.

Schlüsselwörter

Systemmykose - Cryptococcus neoformans - Immunschwäche - Meerschweinchen

Key words

Systemic mycosis - Cryptococcus neoformans - Immunodeficiency - Guinea pig
 

  • Literatur

  • 1 Barwick VS, Wooten MH, Bradfield JF, Myers RD. Fever of unknown origin: due to C. albicans or other fungi acting on the hypothalamus?. Brain Res 1994; 635: 1-8.
    CrossrefPubMedGoogle Scholar
  • 2 Bennett JE. Cryptococcal skin test antigen: preparation variables and characterization. Infect Immun 1981; 32: 373-80.
    PubMedGoogle Scholar
  • 3 Bertschinger HU, Scholer HJ. Spontane Cryptococcose beim Meerschweinchen. Pathol Microbiol, Basel 1965; 28: 12-20.
    PubMedGoogle Scholar
  • 4 Betty MJ. Spontaneous cryptococcal meningitis in a group of guinea pigs caused by a hyphae-producing strain. J Comp Pathol 1977; 87: 377-82.
    CrossrefPubMedGoogle Scholar
  • 5 Blaschke-Hellmessen R. Cryptococcus species – etiological agents of zoonoses or sapronosis?. Mycoses 2000; 43 (Suppl. 01) 48-60.
    PubMedGoogle Scholar
  • 6 Breen JF, Lee IC, Vogel FR, Friedman H. Cryptococcal capsular polysaccharide-induced modulation of murine immune responses. Infect Immun 1982; 36: 47-51.
    PubMedGoogle Scholar
  • 7 Bruatto M, Vidotto V, Maina AM. Growth of Cryptococcus neoformans in a thiamine-free medium. Mycopathologia 1992; 119: 129-32.
    CrossrefPubMedGoogle Scholar
  • 8 Cabanes FJ, Abarca ML, Bonavia R, Bragulat MR, Castella G, Ferrer L. Cryptococcosis in a cat seropositive for feline immunodeficiency virus. Mycoses 1995; 38: 131-3.
    CrossrefPubMedGoogle Scholar
  • 9 Clemons KV, Calich VL, Burger E, Filler SG, Grazziutti M, Murphy J, Roilides E, Campa A, Dias MR, Edwards Jr JE, Fu Y, Fernandes-Bordignon G, Ibrahim A, Katsifa H, Lamaignere CG, Meloni-Bruneri LH, Rex J, Savary CA, Xidieh C. Pathogenesis I: interactions of host cells and fungi. Med Mycol 2000; 38 (Suppl. 01) 99-111.
    CrossrefPubMedGoogle Scholar
  • 10 Connor DH, Chandler FW, Manz HJ, Lack EE. Pathology of Infectious Diseases. Stamford, Connecticut: Appleton & Lange 1997; II: 1707.
    PubMedGoogle Scholar
  • 11 Faggi E, Gargani G, Pizzirani C, Pizzirani S, Saponetto N. Cryptococcosis in domestic mammals. Mycoses 1993; 36: 165-70.
    PubMedGoogle Scholar
  • 12 Feldmesser M, Tucker S, Casadevall A. Intracellular parasitism of macrophages by Cryptococcus neoformans . Trends Microbiol 2001; 09: 273-8.
    CrossrefPubMedGoogle Scholar
  • 13 Ikeda R, Shinoda T, Morita T, Jacobson ES. Characterization of a phenol oxidase from Cryptococcus neoformans var. neoformans . Microbiol Immunol 1993; 37: 759-64.
    CrossrefPubMedGoogle Scholar
  • 14 Jacobs GJ, Medleau L, Calvert C, Brown J. Cryptococcal infection in cats: factors influencing treatment outcome, and results of sequential serum antigen titers in 35 cats. J Vet Intern Med 1997; 11: 1-4.
    CrossrefPubMedGoogle Scholar
  • 15 Jones AE, Reiss E, Spira TJ. A microsomal fraction of Cryptococcus neoformans induces lymphocyte blastogenesis in infected guinea pigs. Mycopathologia 1981; 75: 129-38.
    CrossrefPubMedGoogle Scholar
  • 16 Kano R, Fujino Y, Takamoto N, Tsujimoto H, Hasegawa A. PCR detection of the Cryptococcus neoformans CAPS9 gene from a biopsy specimen from a case of feline cryptococcosis. J Vet Diagn Invest 2001; 13: 439-42.
    CrossrefPubMedGoogle Scholar
  • 17 Khardori N, Butt F, Rolston KV. Pulmonary cryptococcosis in AIDS. Chest 1988; 93: 1319-20.
    PubMedGoogle Scholar
  • 18 Kozel TR. Opsonization and phagocytosis of Cryptococcus neoformans . Arch Med Res 1993; 24: 211-8.
    PubMedGoogle Scholar
  • 19 Kwon-Chung KJ. Morphogenesis of Filobasidiella neoformans, the sexual state of Cryptococcus neoformans . Mycologia 1976; 68: 821-33.
    CrossrefPubMedGoogle Scholar
  • 20 Kwon-Chung KJ. A new species of Filobasidiella, the sexual state of Cryptococcus neoformans B and C serotypes. Mycologia 1976; 68: 943-6.
    PubMedGoogle Scholar
  • 21 Lee SC, Dickson DW, Casadevall A. Pathology of cryptococcal meningoencephalitis: analysis of 27 patients with pathogenetic implications. Hum Pathol 1996; 27: 839-47.
    CrossrefPubMedGoogle Scholar
  • 22 Madewell BR, Holmberg CA, Ackerman N. Lymphosarcoma and cryptococcosis in a cat. J Am Vet Med Assoc 1979; 175: 65-8.
    PubMedGoogle Scholar
  • 23 Mitchell TG, Perfect JR. Cryptococcosis in the era of AIDS – 100 years after the discovery of Cryptococcus neoformans . Clin Microbiol Rev 1995; 08: 515-48.
    CrossrefPubMedGoogle Scholar
  • 24 Nosanchuk JD, Shoham S, Fries BC, Shapiro DS, Levitz SM, Casadevall A. Evidence of zoonotic transmission of Cryptococcus neoformans from a pet cockatoo to an immunocompromised patient. Ann Intern Med 2000; 132: 205-8.
    PubMedGoogle Scholar
  • 25 Polacheck I, Hearing VJ, Kwon-Chung KJ. Biochemical studies of phenoloxidase and utilization of catecholamines in Cryptococcus neoformans . J Bacteriol 1982; 150: 1212-20.
    PubMedGoogle Scholar
  • 26 Powell KE, Dahl BA, Weeks RJ, Tosh FE. Airborne Cryptococcus neoformans: particles from pigeon excreta compatible with alveolar deposition. J Infect Dis 1972; 125: 412-5.
    CrossrefPubMedGoogle Scholar
  • 27 Riera CM, Masih DT, Nobile R. Experimental cryptococcosis in guinea pigs. Mycopathologia 1983; 82: 179-84.
    CrossrefPubMedGoogle Scholar
  • 28 Rozenbaum R, Goncalves AJ. Clinical epidemiological study of 171 cases of cryptococcosis. Clin Infect Dis 1994; 18: 369-80.
    CrossrefPubMedGoogle Scholar
  • 29 Swinne D, Deppner M, Laroche R, Floch JJ, Kadende P. Isolation of Cryptococcus neoformans from houses of AIDS-associated cryptococcosis patients in Bujumbura (Burundi). Aids 1989; 03: 389-90.
    CrossrefPubMedGoogle Scholar
  • 30 Van Cutsem J, Fransen J, Van Gerven F, Janssen PA. Experimental cryptococcosis: dissemination of Cryptococcus neoformans and dermotropism in guinea-pigs. Mykosen 1986; 29: 561-75.
    PubMedGoogle Scholar
  • 31 van Herck H, van den Ingh TS, van der Hage MH, Zwart P. Dermal cryptococcosis in a guinea pig. Lab Anim 1988; 22: 88-91.
    CrossrefPubMedGoogle Scholar
  • 32 Vecchiarelli A. Immunoregulation by capsular components of Cryptococcus neoformans . Med Mycol 2000; 38: 407-17.
    CrossrefPubMedGoogle Scholar
  • 33 Vecchiarelli A, Casadevall A. Antibody-mediated effects against Cryptococcus neoformans: evidence for interdependency and collaboration between humoral and cellular immunity. Res Immunol 1998; 149: 321-33 discussion 500-3..
    CrossrefPubMedGoogle Scholar
  • 34 Vorreith M. Mycotic encephalitis. Acta Neuropathol (Berl) 1968; 11: 55-68.
    CrossrefPubMedGoogle Scholar