Tierarztl Prax Ausg K Kleintiere Heimtiere 2010; 38(02): 71-78
DOI: 10.1055/s-0038-1622833
Originalartikel
Schattauer GmbH

Einsatz von SISTM (Small Intestinal Submucosa) bei der Hernia perinealis des Hundes

Eine retrospektive StudieSurgical therapy of perineal hernia in dogs by the use of Small Intestinal Submucosa (SISTM).A retrospective study
C. Thiel
1   Klinik für Kleintiere, Chirurgie (Prof. Dr. M. Kramer), Justus-Liebig-Universität Gießen
,
A. Fischer
1   Klinik für Kleintiere, Chirurgie (Prof. Dr. M. Kramer), Justus-Liebig-Universität Gießen
,
M. Kramer
1   Klinik für Kleintiere, Chirurgie (Prof. Dr. M. Kramer), Justus-Liebig-Universität Gießen
,
O. Lautersack
1   Klinik für Kleintiere, Chirurgie (Prof. Dr. M. Kramer), Justus-Liebig-Universität Gießen
› Institutsangaben
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Publikationsverlauf

Eingegangen: 23. Juni 2009

Akzeptiert: 03. Dezember 2009

Publikationsdatum:
05. Januar 2018 (online)

Zusammenfassung

Gegenstand: Therapie der Hernia perinealis beim Hund mittels Einsatz von SISTM. Material und Methoden: Retrospektive Auswertung der prä-, intra-, und postoperativen Daten von 15 Hunden mit 21 Perinealhernien, die von Juli 2003 bis Januar 2005 im Klinikum Veterinärmedizin, Klinik für Kleintiere, Chirurgie der Justus-Liebig-Universität Gießen operativ mittels Einsatz von SISTM therapiert wurden. Ergebnisse: Bei 11 Hunden wurde die Ausprägung der Perinealhernie als hochgradig eingestuft, bei vier Patienten als mittelgradig. Das Körpergewicht der Hunde lag bei 5–51 kg (Ø 20 kg). Bei Vorstellung wiesen 86,7% der Patienten Kotabsatzbeschwerden auf, 40% der Hunde zeigten eine perineale Schwellung. Eine Retroflexio vesicae wurde bei vier Hunden diagnostiziert. Die durchschnittliche Operationszeit betrug 58,1 Minuten (50–70 Minuten). Intraoperative Komplikationen traten nicht auf. Post-operativ kam es nur zu geringfügigen Komplikationen (Serombildung: sechs Hunde, geringgradige Nahtdehiszenz: drei Tiere), die nur in drei Fällen eine lokale Therapie erforderlich machten. Langzeitergebnisse wurden mittels rektaler Kontrolluntersuchung sowie telefonischer Besitzerbefragung 6–36 Monate postoperativ (Ø 25,2 Monate) ermittelt. Bei 19 operierten Perinealhernien konnte das Ergebnis als sehr gut bis gut eingestuft werden. Die Rezidivrate klinischer Symptome einer Perinealhernie lag bei 9,5% (zwei von 21 Perinealhernien). Schlussfolge-rung und klinische Relevanz: Der Einsatz von SISTM zur Therapie der Perinealhernie beim Hund ist eine einfache und sichere Methode. Die Langzeitverträglichkeit des Implantats erscheint sehr gut, die Rezidiv-rate klinischer Symptome ist gering. In Fällen, in denen der Defekt durch körpereigenes atrophiertes Gewebe nicht verschlossen werden kann oder die Ausmaße der Perinealhernie diesen Verschluss nicht zulassen, kann die Verwendung des Implantats erwogen werden. Ein Nachteil sind die zusätzlich anfallenden Materialkosten für das Implantat.

Summary

Objective: Surgical therapy of perineal hernia in dogs by using Small Intestinal Submucosa (SISTM). Material and methods: Retrospective evaluation of pre-, intra-, and postoperative data of 15 dogs for which a total of 21 perineal hernias were surgically treated by implantation of SISTM between July 2003 to January 2005 at the Hospital for Small Animals, Surgery, Justus Liebig University of Giessen. Results: Eleven of the 15 dogs showed a large sized perineal hernia, whereas in four dogs the defect was of medium size. Preoperatively, 86.7% of the patients showed defecation problems and 40% had perineal swelling. Retroflexion of the bladder was observed in four dogs. Average operation time was 58.1 minutes (50–70 minutes). No intraoperative complications were observed. Postoperative complications were minor (seroma formation in six patients, minor wound dehiscence in three dogs), and only three cases required local therapy. Implant intolerance was not observed. Long-term results were obtained 6–36 months postoperatively (mean 25.2 months) by rectal examination and owner telephone questionnaire. The recurrence rate, based on clinical signs of perineal hernia, was 9.5% (two of 21 perineal hernias). Results were rated excellent to good in 19 of the 21 surgically treated perineal hernias. Conclusion and clinical relevance: Implantation of SISTM in the treatment of perineal hernia in dogs is an easy and safe treatment option. Long-term implant tolerance appears to be excellent. Recurrence rate of clinical signs is low. In cases where the defect can not be closed with endogenous tissue, either due to atrophic tissue or dimensions of peri-neal hernia do not allow such closure, the use of Small Intestinal Submucosa should be considered. The additional costs for the implant are however a disadvantage of this method.

 
  • Literatur

  • 1 Badylak SF, Lantz GC, Coffey AC. Small intestine submucosa as a large dia -meter vascular graft in the dog. J Surg Res 1989; 47: 74-80.
  • 2 Badylak SF. SIS: A biomaterial conducive to smart tissue remodelling. In: Tissue Engineering: Current Prospectives Bell E. ed Cambridge: Burkhauser; 1993: 179-189.
  • 3 Badylak SF, Coffey AC, Lantz GC. A comparison of the resistance to infection of intestinal submucosa arterial grafts versus polytetrafluorethylene arterial prosthesis in a dog model. J Vasc Surg 1994; 19: 465-472.
  • 4 Badylak SF, Tullius R, Kokini K. The use of xenogenic small intestinal sub -mucosa as a biomaterial for achille’s tendon repair in a dog model. J Biomed Mater Res 1995; 29: 977-985.
  • 5 Bellenger CR. Perineal hernia in dogs. Austr Vet J 1980; 56: 434-437.
  • 6 Bellenger CR, Canfield RB. Perineal Hernia. In: Textbook of Small Animal Surgery 3rd ed.. Slatter D. ed Philadelphia: Saunders; 2003: 487-498.
  • 7 Benitah N, Matousek JL, Barnes RF, Lichtensteiger CA, Campbell KL. Diaphragmatic and perineal hernias associated with cutaneous asthenia in a cat. J Am Vet Med Assoc 2004; 224 (05) 706-709.
  • 8 Bilbrey SA, Smeak DD, De Hoff W. Fixation of the deferent ducts for retro -displacement of the urinary bladder and prostate in canine perineal hernia. Vet Surg 1990; 19: 24-27.
  • 9 Böttcher P, Thiel C, Kramer M, Grevel V. Die Transposition des M. semitendinosus zur Versorgung ventraler Perinealhernien bein Hund – retrospektive Auswertung von sechs Fällen (2003-2005.). Tierärztl Prax 2007; 35: 93-101.
  • 10 Bongartz A, Carofiglio F, Balligand M, Heimann M, Hamaide A. Use of auto-genous fascia lata graft for perineal herniorrhaphy in dogs. Vet Surg 2005; 34: 405-413.
  • 11 Borthwick R, Mackenzie CP. The signs and results of prostatic disease in dogs. Vet Rec 1971; 89: 374-384.
  • 12 Brissot HN, Dupre GP, Bouvy BM. Use of laparotomy in a staged approach for resolution of bilateral or complicated perineal hernia in 41 dogs. Vet Surg 2004; 33: 412-421.
  • 13 Chambers JN, Rawlings CA. Application of a semitendinosus muscle flap in two dogs. J Am Vet Med Assoc 1991; 199: 84-86.
  • 14 Clarke KM, Lantz GC, Salisbury SK, Badylak SF, Hiles MC, Voytik SL. Intestine submucosa and polypropylene mesh for abdominal wall repair in dogs. J Surg Res 1996; 60: 107-114.
  • 15 Cobb MA, Badylak SF, Janas W. Histology after dural grafting with small intestinal submucosa. Surg Neurol 1996; 46: 389-393.
  • 16 Dupre GP, Prat N, Bouvy B. Perineal hernia in the dog: evaluation of asso -ciated lesions and results in 60 dogs. Abstract of European College of Veteri -nary Surgeons. Vet Surg 1993; 22: 250
  • 17 Frankland AL. Use of porcine dermal collagen in the repair of perineal hernia in dogs – A preliminary report. Vet Rec 1986; 119: 13-14.
  • 18 Francioni G, Ansaldo V, Magistrelli P. The use of prosthesis in abdominal and thoracic wall defect, 15 years experience: Evaluation of tissue reactions and complications. Chir Ital 1999; 51: 21-30.
  • 19 Galanty M. Perineal hernia in 3 cats. Pol J Vet Sci 2005; 8 (02) 165-168.
  • 20 Greiner TP, Johnson RG. Diseases of the prostate gland. In: Textbook of Veterinary Internal Medicine 3rd ed.. Ettinger SJ. ed Philadelphia: Saunders; 1989: 1561-1563.
  • 21 Hayes Jr HM. The epidemiologic features of perineal hernia in 771 dogs. J Am Anim Hosp Assoc 1978; 14: 703-707.
  • 22 Head LL, Francis DA. Mineralized paraprostatic cyst as a potential contributing factor in the development of perineal hernias in a dog. J Am Vet Med Assoc 2002; 221: 533-535.
  • 23 Hedlund CS. Surgery of the digestive system. In: Small Animal Surgery 2nd ed.. St. Louis: Mosby; 2002: 433-437.
  • 24 Hiles MC, Badylak SF, Geddes LA. Porosity of porcine small intestinal submucosa for use of vascular graft. J Biomed Mater Res 1993; 27: 139-144.
  • 25 Hosgood G. Perineal herniorrhaphy: Perioperative data from 100 dogs. J Am Anim Hosp Assoc 1995; 31: 331-342.
  • 26 Kropp BP, Rippy MK, Badylak SF. Regenerative urinary bladder augmentation using small intestinal submucosa: Urodynamic and histopathologic assessment in long term canine bladder augmentation. J Urol 1996; 155: 2098-2104.
  • 27 Lantz GC, Badylak SF, Coffey AC. Small intestinal submucosa as a superior vena cava graft in the dog. J Surg Res 1992; 53: 175-181.
  • 28 Larsen JS. Perineal herniorrhaphy in dogs. J Am Vet Med Assoc 1966; 149: 277-280.
  • 29 Mann FA, Boothe HW, Amos MS, Tangner CH, Puglisi TA, Hobson HP. Serum testosterone and estradiol 17-beta concentrations in 15 dogs with perineal hernia. J Am Vet Med Assoc 1989; 194: 1578-1580.
  • 30 Mann FA. Androgen receptors in the pelvic diaphragm muscles of dogs with and without perineal hernia. Am J Vet Res 1995; 56: 134-139.
  • 31 Niebauer GW, Shibly S, Seltenhammer M, Pirker A, Brandt S. Relaxin of prostatic origin might be linked to perineal hernia formation in dogs. Annals of the New York Academy of Sciences 2005; 1041: 415-422.
  • 32 Niles JD, Williams JM. Perineal hernia with bladder retroflexion in a female cocker spaniel. J Small Anim Pract 1999; 40: 92-94.
  • 33 Orsher RJ, Johnston DE. The surgical treatment of perineal hernia in dogs by transposition of the obturator muscle. Comp Cont Educ Vet Pract 1985; 7: 233-239.
  • 34 Orsher RJ. Clinical and surgical parameters in dogs with perineal hernia. Analysis of results of internal obturator transposition. Vet Surg 1986; 15: 253-258.
  • 35 Prevel CD, Eppley BL, Summerlin DJ. Small intestinal submucosa: Uti -lization for repair of rodent abdominal wall defects. Ann Plast Surg 1995; 35: 374-380.
  • 36 Raffan PJ. A new surgical technique for repair of perineal hernias in the dog. J Small Anim Pract 1993; 34: 13-19.
  • 37 Risselada M, Kramer M, Van de Velde B, Polis I, Gortz K. Retroflexion of the urinary bladder associated with a perineal hernia in a female cat. J Small Anim Pract 2003; 44 (11) 508-510.
  • 38 Robertson JJ. Perineal hernia repair in dogs. Mod Vet Pract 1984; 5: 365-368.
  • 39 Shahar R. A possible association between acquired nontraumatic inguinal and perineal hernia in adult male dogs. Can Vet J 1996; 37: 614-616.
  • 40 Sjollema BE, Van Slujis FJ. Perineal hernia repair in the dog by transposition of the internal obturator muscle. II: Complications and results in 100 patients. Vet Q 1989; 11: 18-23.
  • 41 Sjollema BE. Electromyography of the pelvic diaphragm and anal sphincter in dogs with perineal hernia. Am J Vet Res 1993; 54: 185-190.
  • 42 Spillmann T, Gerwing M, Michele U, Bauer C, Kopf N, Rössel C, Fahrenkrug P. Hernia perinealis. In: Klinik der Hundekrankheiten, 3. Aufl Stuttgart: Enke; 2007: 587-590.
  • 43 Spreull JSA, Frankland AL. Transplanting the superficial gluteal muscle in the treatment of perineal hernia and flexure of the rectum in the dog. J Small Anim Pract 1980; 21: 265-275.
  • 44 Stoll MR, Cook JL, Pope ER, Carson WL, Kreeger JM. The use of porcine small intestinal submucosa as a biomaterial for perineal herniorrhaphy in the dog. Vet Surg 2002; 31: 379-390.
  • 45 Szabo S, Wilkens B, Radasch RM. Use of polypropylene mesh in addition to internal obturator transposition: a review of 59 cases (2000-2004). J Am Anim Hosp Assoc 2007; 43: 136-142.
  • 46 Thiel C, Peppler C, Lautersack O, Kramer M. Retrospektive Studie über den Einsatz eines Polyglecapron-Polypropylen Netzes (Ultrapro) bei der Hernia perinealis des Hundes. Wien Tierärztl Mschr 2008; 95: 178-183.
  • 47 Thissen HJ, Rahlfs I. Zur Perinealhernie des Hundes – eine Erfolgskontrolle in 154 (72) Fällen. Kleintierprax 1986; 31: 167-168.
  • 48 Vnuk D, Babic T, Stejskal M, Capak D, Harapin I, Pirkic B. Application of a semitendinosus muscle flap in the treatment of perineal hernia in a cat. Vet Rec 2005; 156 (06) 182-184.
  • 49 Voytik-Harbin SL, Brightman AO, Kraine MR. Small intestinal submucosa: A tissue derived extracellular matrix that promotes tissue specific growth and differentiation of cells in vitro. Tissue Eng 1998; 4: 157-162.
  • 50 Weaver AD, Omamegbe JO. Surgical treatment of perineal hernia in the dog. J Small Anim Pract 1981; 22: 749-758.