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Nuklearmedizin 1985; 24(03): 107-110
DOI: 10.1055/s-0038-1624287
Short Communications – Kurzmitteilungen
Schattauer GmbH

Quantitative Radioisotope Measurement of Duodenogastric Reflux in Patients with Ulcer or Gastrectomized for Ulcer

Quantitative Bestimmung des duodeno-gastralen Refluxes bei Patienten mit Ulkus oder nach BI Resektion mittels einer Radioisotopen-Methode
S. Hyödynmaa
1   From the Departments of Clinical Physiology, University Central Hospital, Kuopio, Finland
,
M. Pääkkönen
3   From the Surgery, University Central Hospital, Kuopio, Finland
,
S. Aukee
3   From the Surgery, University Central Hospital, Kuopio, Finland
,
K. Korhonen
2   From the Clinical Chemistry, University Central Hospital, Kuopio, Finland
,
A. Pääkkönen
1   From the Departments of Clinical Physiology, University Central Hospital, Kuopio, Finland
,
E. Länsimies
1   From the Departments of Clinical Physiology, University Central Hospital, Kuopio, Finland
› Author AffiliationsThe authors wish to thank Dr. P. Y. Karjalainen, Ph. D., and Ass. Prof. E. M. Alhava, M. D., for their critical comments during this work.
Further Information

Publication History

Received: 12 January 1985

Publication Date:
20 January 2018 (online)

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Summary

In this work the duodenogastric reflux was quantified as the amount of radioactivity entering the stomach after an i.v. administration of 99mmTc-HIDA in ulcer patients and in patients who had undergone BI gastrectomy. The results were compared with visual evidence of gastric activity in the gamma camera images and biochemical determination of gastric bile reflux. The method is useful in quantifying the reflux if the activity is above the background activity. It allows the determination of an upper limit for the reflux when the reflux is evident visually. Only two or three images are needed for the quantitation. No correlation was found between biochemical measurement of fasting bile reflux in the stomach and radioisotopic quantification.

Zusammenfassung

In dieser Arbeit wurde der duodenogastrale Reflux als die Menge der Radioaktivität quantifiziert, die nach i. v. Injektion von 99mTc-HIDA in den Magen fließt. Die Ergebnisse wurden mit der visuell im Magenszintigramm erkennbaren Radioaktivität und mit der biochemischen Gallereflux-Untersuchung verglichen. Diese Methode erwies sich als nützlich in der quantitativen Messung der Refluxaktivität, wenn diese größer als die Background-Aktivität war. Dadurch ist es möglich, die Obergrenze zu bestimmen, bei der der Reflux szintigraphisch sichtbar ist. Für die Quantifizierung werden nur zwei oder drei Szintigramme benötigt. Keine Korrelation wurde zwischen der biochemischen und der nuklearmedizinischen Quantifizierung eines Gallerefluxes gefunden.

 

  • References

  • 1 Begeman F, Schumpelick V. Schumpelick: Problems in duodenogastric reflux assessment during bile acid and lysolecitin measurement. Scand. J. Gastroenterol 1981; (16) Suppl. 67: 51-3.
    Google Scholar
  • 2 Eyre-Brook I. A, Holroyd A. M, Johnson A. G. A single isotope method of post-prandial duodenogastric reflux assessment using ““Tc-labelled IDA in patients with gallstones. Clin. Phys. Physiol. Meas 1983; 04: 299-307.
    CrossrefPubMedGoogle Scholar
  • 3 Gustavsson S, Enander L. K, Jung B, Krog M. Scintigraphic assessment of biliary reflux into the residual stomach after subtotal gastrectomy and gastrojejunostomy. Acta Radiol. Diagn 1980; 21: 639-43.
    Google Scholar
  • 4 Hoare A. M, Keighley M. R. B, Starkey B, Alexander-Williams J. Measurement of bile acids in fasting gastric aspirates: An objective test for bile reflux after gastric surgery. Gut 1978; 19: 166-9.
    CrossrefPubMedGoogle Scholar
  • 5 Kalima T, Matikainen M, Taavitsainen M. The detection of duodenogastric reflux with a non-invasive method using cholescintigraphy. Scand. J. Gastroenterol 1981; (16) 67: 37-41.
    Google Scholar
  • 6 Muhammed I, McLoughlin G. D, Holt S, Taylor T. V. Non-invasive estimation of duodenogastric reflux using Technetium-99 m p-butyl-iminodiacetic acid. Lancet 1980; II: 1162-5.
    PubMedGoogle Scholar
  • 7 Müller-Lissner S. A, Fimmel C. J, Sonnenberg A, Will N, Müller-Duysing W, Heinzel F, Muller R, Blum A. L. Novel approach to quantify duodenogastric reflux in healthy volunteers and in patients with type I gastric ulcer. Gut 1983; 24: 510-8.
    CrossrefPubMedGoogle Scholar
  • 8 Müller-Lissner S. A, Sonnenberg A, Müller-Duysing W, Will N, Heinzel F, Blum A. L. Quantitative measurement of duodenogastric reflux in man. I. Methodology. Scand. J. Gastroenterol 1981; (16) 67: 43-6.
    Google Scholar
  • 9 Niemelä S, Heikkilä J, Lehtola J. Duodenogastric reflux as measured by an isotope technique and its correlation with endoscopic findings. Ann. clin. Res 1983; 15: 146-50.
    PubMedGoogle Scholar
  • 10 Tolin R. D, Malmud L. S, Stelzer F, Menin R, Makler P. T, Applegate G, Fischer R. S. Enterogastric reflux in normal subjects and patients with Billroth II gastrectomy: Measurement of enterogastric reflux. Gastroenterology 1979; 77: 1027-33.
    PubMedGoogle Scholar