Long-Term Clinical Investigation of the Hepatobiliary Agents: 99mTc- HIDA and 99mTC-p-Butyl-IDA

N. H. Agha; A. M. AI-Hilli; N. D. Dahir; M. S. Al-Hissoni; M. N. Jasim; K. M. Miran; H. Shubber Amira

doi:10.1055/s-0038-1624339

Nuklearmedizin - NuclearMedicine, Table of Contents

Nuklearmedizin 1986; 25(05): 181-187
DOI: 10.1055/s-0038-1624339

Originalarbeiten - Original Articles

Schattauer GmbH

Long-Term Clinical Investigation of the Hepatobiliary Agents: ^99mTc- HIDA and ^99mTC-p-Butyl-IDA

N. H. Agha

¹From the Nuclear Research Centre, Radioisotope Production Department, Baghdad, College of Medicine, Al-Mustanserria University, Baghdad, Iraq

,

A. M. AI-Hilli

¹From the Nuclear Research Centre, Radioisotope Production Department, Baghdad, College of Medicine, Al-Mustanserria University, Baghdad, Iraq

,

N. D. Dahir

¹From the Nuclear Research Centre, Radioisotope Production Department, Baghdad, College of Medicine, Al-Mustanserria University, Baghdad, Iraq

,

M. S. Al-Hissoni

^*From the Nuclear Research Centre, Radioisotope Production Department, Baghdad, and the Department of Nuclear Medicine, College of Medicine, Al-Mustanserria University, Baghdad, Iraq

,

M. N. Jasim

^*From the Nuclear Research Centre, Radioisotope Production Department, Baghdad, and the Department of Nuclear Medicine, College of Medicine, Al-Mustanserria University, Baghdad, Iraq

,

K. M. Miran

^*From the Nuclear Research Centre, Radioisotope Production Department, Baghdad, and the Department of Nuclear Medicine, College of Medicine, Al-Mustanserria University, Baghdad, Iraq

,

H. Shubber Amira

^**From the Ebin Al-Nafees Hospital for Cardiovascular Diseases and Yarmouk Teaching Hospital, College of Medicine, Al-Mustanserria University, Baghdad, Iraq

› Author Affiliations

Abstract

The organ distribution data for the two hepatobiliary agents HIDA and p-butyl- IDA in mice showed substantial differences in the extent and rate of hepatobiliary clearance of radioactivity. ^99mTc-HIDA and ^99mTc-p-butyl-IDA were used in computer assisted serial hepatobiliary scintigraphy. In normal subjects, the data of dynamic studies showed that the kidneys were no longer seen after 2.5 min with p-butyl-IDA. Liver radioactivity decreased significantly after 10 min with HIDA compared to 35 min with p-butyl-IDA. The gall bladder was always visualized at the 10-12th min and the 25-30th min with HIDA and p-butyl-IDA respectively. ^99mTc-HIDA provided superior hepatic duct images.

Zusammenfassung

Die Organverteilung der beiden hepatobiliären Agenzien HIDA und p-butyl-IDA wiesen bei der Maus erhebliche Unterschiede in Ausmaß und Schnelligkeit der hepatobiliären Radioaktivitätsclearance auf. ^99mTc- HIDA und ^99mTc-p-butyl-IDA wurden für die computerunterstützte hepatobiliäre Sequenzszintigraphie eingesetzt. Bei Normalpersonen zeigte die dynamische Studie, daß die Nieren mit p-butyl-IDA nach 2.5 min nicht mehr sichtbar waren. Die Radioaktivität in Leberparenchymen nahm signifikant ab der 10, min bei HIDA und ab der 35. min bei p-butyl-IDA ab. Die Gallenblase wurde immer zwischen der 10.-12. min und 25.-30. min mit HIDA bzw. p-butyl- IDA dargestellt. Eine bessere Darstellung der Gallenwege war mit ^99mTc-HIDA gewährleistet.

revised form: April 25, 1986

Full Text

References

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