Hat die antidepressive TMS klinische Bedeutung?

U. Herwig; M. Spitzer; C. Schönfeldt-Lecuona

doi:10.1055/s-0038-1624394

Nervenheilkunde, Table of Contents

Nervenheilkunde 2003; 22(04): 196-199
DOI: 10.1055/s-0038-1624394

Original- und Übersichtsarbeiten/Original and Review Articles

Schattauer GmbH

Hat die antidepressive TMS klinische Bedeutung?

Argumentation für eine multizentrische StudieDoes antidepressant TMS exert a clinically meaningful effect?Arguing for a multicentric study

U. Herwig

¹Psychiatrische Universitätsklinik Zürich (Chefärztin GPZ: Priv.-Doz. Dr. U. Schreiter-Gasser)

²Abt. Psychiatrie III, Universität Ulm (Direktor: Prof. Dr. Dr. M. Spitzer)

,

M. Spitzer

²Abt. Psychiatrie III, Universität Ulm (Direktor: Prof. Dr. Dr. M. Spitzer)

,

C. Schönfeldt-Lecuona

²Abt. Psychiatrie III, Universität Ulm (Direktor: Prof. Dr. Dr. M. Spitzer)

› Author Affiliations

Abstract

Zusammenfassung

Die transkranielle Magnetstimulation (TMS) gilt als eine möglich neue Therapiemethode für Depressionen. Die bisher dazu veröffentlichten Studien sind jedoch an kleinen Patientengruppen und mit heterogenen Stimulationsparametern durchgeführt worden. Zwar wird meist ein statistisch signifikanter antidepressiver Effekt beschrieben, dieser ist aber klinisch moderat. Diese Übersicht fasst die Ergebnisse aktueller Metaanalysen zusammen und eröffnet einen Vorschlag für das Design einer multizentrischen Studie. Ohne diese lässt sich die Frage nach der klinischen Bedeutung der antidepressiven TMS noch nicht beantworten.

Summary

Transcranial magnetic stimulation (TMS) may serve as a new antidepressant treatment. The related published studies however studied few patients and used heterogenic stimulation parameters. Despite mostly a statistically significant effect is reported, the clinical effect is moderate. This review summarizes recent meta-analyses and proposes a multicentric study. Without such a study the question of a clinically meaningful antidepressant effect of TMS won’t be answered.

Schlüsselwörter

Depression - transkranielle Magnetstimulation - Multicenter-Studie

Keywords

Depression - transcranial magnetic stimulation - multicentric study

Full Text

References

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