Download PDF
Nuklearmedizin 1973; 12(04): 346-359
DOI: 10.1055/s-0038-1624836
Originalarbeiten — Original Articles — Travaux Originaux
Schattauer GmbH

113mIn-Macroaggregate Stabilized with PVP for Lung Scanning

113mIn-macroagrégat stabilisé par PVP utilisé en scintigraphic pulmonaire 113mIn-Makroaggregat stabilisiert mit PVP zur Lungenszintigraphie
Z. Rybakow   *
1   Institute of Drugs, Laboratory of Radioisotopic Drugs and Institute of Nuclear Research, The Radioisotope Production and Distribution Centre, Swierk near Warsaw
,
I. Licińska   **
1   Institute of Drugs, Laboratory of Radioisotopic Drugs and Institute of Nuclear Research, The Radioisotope Production and Distribution Centre, Swierk near Warsaw
,
E. Lachnik   *
1   Institute of Drugs, Laboratory of Radioisotopic Drugs and Institute of Nuclear Research, The Radioisotope Production and Distribution Centre, Swierk near Warsaw
,
A. Kulesza   *
1   Institute of Drugs, Laboratory of Radioisotopic Drugs and Institute of Nuclear Research, The Radioisotope Production and Distribution Centre, Swierk near Warsaw
,
A. Sakowicz   *
1   Institute of Drugs, Laboratory of Radioisotopic Drugs and Institute of Nuclear Research, The Radioisotope Production and Distribution Centre, Swierk near Warsaw
› Author Affiliations
Further Information

Publication History

Received:25 July 1973

Publication Date:
05 February 2018 (online)

Also available at
    Permissions and Reprints

On présente une méthode convenable et répétable de la préparation du macroagregat 113mIn-Fe (OH)3, stabilisé par le PVP, qui est utilisé en scintigraphic pulmonaire.

L’influence du temps de chauffage sur la répartition de la préparation dans les organes de la souris a été étudié et le temps optimal a été choisi.

Summary

An "instant" kit for the preparation of 113mIn-Fe (OH)3 macroaggregate with PVP as a stabilizer has been described. The procedure is simple and reproducible. Using this kit and the described procedure a sterile and pyrogen-free lung scanning agent may be prepared in 15 minutes. Variations of organ distributions with heating time have been studied.

Es wurde ein Kit zur Darstellung von PVP-stabilisiertem 113mIn-Fe (OH)3 Makroaggregat beschrieben. Die Methode ist einfach und gut wiederholbar.

Wenn der beschriebene Kit und das angegebene Verfahren angewandt wird, kann man das sterilisierte und apyrogene Präparat in 15 Minuten bekommen. Das Präparat hat gute szintigraphische Eigenschaften. Die Verteilung des Präparates im Organismus wurde untersucht in Abhängigkeit von der Erwärmungstemperatur bei der Zubereitung des Präparates.

* Institute of Nuclear Research, The Radioisotope Production and Distribution Centre.


** Institute of Drugs, Laboratory of Radioisotopic Drugs.


 

  • References

  • 1 Adatepe M. H, Welch M, Archer E, Studer R, Potchen E. J. The laboratory preparation of indium-labeled compounds. J. Nucl. Med 1968; 9: 426-427.
    PubMedSearch in Google Scholar
  • 2 Bruno F. P, Sorsdahl O. A, Williams C. M. An improved for the preparation of indium labeled lung and liver scanning compounds. Am. J. Roentgen 1968; 104: 762-765.
    CrossrefPubMedSearch in Google Scholar
  • 3 Cooper J. F, Wagner Jr. H. N. Preparation and control of 113mln radiopharmaceuticals. Proceedings of a panel on preparation and control of radiopharmaceuticals from generator-produced radionuclides. Vienna, 11–15 May. 1970: 83-89.
    Search in Google Scholar
  • 4 Ege G. N, Richards L. P. Introducing PVP as a stabilizer in the preparation of technetium sulphur colloid. Br. J. Radiol 1969; 42: 552
    CrossrefPubMedSearch in Google Scholar
  • 5 French R. J. Correspondence. Br. J. Radiol 1969; 42: 68-69.
    CrossrefPubMedSearch in Google Scholar
  • 6 Garnett E. S. Non-gelatin containing indium scanning agents. Br. J. Radiol 1969; 42: 236
    PubMedSearch in Google Scholar
  • 7 Garnell E. S, Bayly R. J, Marlow C. G. Pyrogen-free 113mln scanning agents. Br. J. Radiol 1969; 42: 709-710.
    CrossrefPubMedSearch in Google Scholar
  • 8 Garzon D. L, Palcos M. C, Radicella R. A technetium-99m labeled colloid. Int. J. Appl. Rad. Isot 1965; 16: 613-615.
    Search in Google Scholar
  • 9 Gemmill W. J, Scott D. M, Kramer H. H. Alternate way to produce 113mln-macro-iron hydroxide. J. Nucl. Med 1968; 9: 170-171.
    PubMedSearch in Google Scholar
  • 10 Goodwin D. A, Stern H. S, Wagner Jr. H. N. Ferric hydroxide particles labeled with indium In-113mfor lung scanning. JAMA 1968; 206: 339-343.
    CrossrefPubMedSearch in Google Scholar
  • 11 Lopez R. B, French R. J. Stabilizer-free technetium colloid. Br. J. Radiol 1969; 42: 633-635.
    PubMedSearch in Google Scholar
  • 12 Smith E. D, Smoak W. M, Gilson A. J. Letter to the Editor. J. Nucl. Med 1967; 8: 896
    PubMedSearch in Google Scholar
  • 13 Stern H. S, Goodwin D. A, Wagner Jr. H. N, Kramer H. H. In113m— a short lived isotope for lung scanning. Nucleonics 1966; 24: 57-59.
    Search in Google Scholar
  • 14 Szymendera J, Kaminska J, Radwan M, Zoltowski T. PVP — stabilizer indium sulphide colloid for liver and spleen scanning. Br. J. Radiol 1969; 42: 244-245.
    Search in Google Scholar
  • 15 Szymendera J, Malinowski A. Z, Chequillaume J, Tolwinski J. Experience with the preparation and use of 99mTc sulfide colloid. Nucl. Med. (Stuttg.) 1968; 7: 388-395.
    PubMedSearch in Google Scholar