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Nuklearmedizin 1975; 14(04): 374-380
DOI: 10.1055/s-0038-1624919
Originalarbeiten — Original Articles
Schattauer GmbH

The Synthesis and Chemical Properties of 3-Chloromercury-2-Hydroxipropyl-Urea

Die Synthese und die chemischen Eigenschaften des 3-chloromercury-2-hydroxypropylharnstoffs
I. Berkeš
1   Institute of Biochemistry, School of Pharmacy, Belgrade, Boris Kidrič Institute, Vinča, Institute of Pharmaceutical Chemistry, School of Pharmacy, Belgrade
,
V. Jovanović
1   Institute of Biochemistry, School of Pharmacy, Belgrade, Boris Kidrič Institute, Vinča, Institute of Pharmaceutical Chemistry, School of Pharmacy, Belgrade
,
D. Živanov-Stakić
1   Institute of Biochemistry, School of Pharmacy, Belgrade, Boris Kidrič Institute, Vinča, Institute of Pharmaceutical Chemistry, School of Pharmacy, Belgrade
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Publication History

Received:21 March 1975

Publication Date:
12 January 2018 (online)

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Summary

A simple and rapid method for the synthesis of 3-chloromercury-2-hydroxipropyl-urea has been described. It has been concluded that highest yields are obtained by the synthesis of 197HgO and allyl urea in the ratio of 2.5: 1.

Stability of the final preparation was investigated after thermal sterilization and standing at room temperature. It has been proved that the inorganic mercury-197 is not released. Radiochemical purity was controlled by chromatographic method using pyridine, n-butanol and water (3: 10: 3 v/v) as a solvent. The results obtained indicate that the preparation is applicable for human use.

In der Arbeit wird eine schnelle und einfache Methode zur synthetischen Herstellung von 3-chloromercury-2-hydroxypropylharnstoff beschrieben. Es wurde festgestellt, daß die höchsten Syntheseausbeuten beim Gewichtsverhältnis 197HgO zu Allylharnstoff 2,5 : 1 erreicht werden.

Es wurde auch die Beständigkeit des Endpräparates geprüft und dabei nachgewiesen, daß nach Hitzesterilisierung und Raumtemperaturlagerung kein anorganisches Quecksilber-197 frei wird. Zur Prüfung der strahlenchemischen Rein-heit, wurde die chromatographische Methode mit Pyridin, n-Butanol und Wasser (3 : 10 : 3 v/v) als Laufmittel angewendet. Die Prüfungsergebnisse weisen auf die Möglichkeit der Anwendung in der Humanmedizin.

 

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