Psychiatrische Genetik – Gegenwart und Perspektiven

P. Sand; P. Eichhammer; G. Hajak

doi:10.1055/s-0038-1626395

Nervenheilkunde, Table of Contents

Nervenheilkunde 2004; 23(07): 406-414
DOI: 10.1055/s-0038-1626395

Original- und Übersichtsarbeiten - Original and Review Articles

Schattauer GmbH

Psychiatrische Genetik – Gegenwart und Perspektiven

Psychiatric genetics – present achievements and future prospects

Authors

P. Sand

¹Klinik und Poliklinik für Psychiatrie und Psychotherapie der Universität Regensburg (Direktor: Prof. Dr. H. E. Klein)
P. Eichhammer

¹Klinik und Poliklinik für Psychiatrie und Psychotherapie der Universität Regensburg (Direktor: Prof. Dr. H. E. Klein)
G. Hajak

¹Klinik und Poliklinik für Psychiatrie und Psychotherapie der Universität Regensburg (Direktor: Prof. Dr. H. E. Klein)

Abstract

Zusammenfassung

Psychiatrische Störungen entwickeln sich aus dem Zusammenspiel von Umwelteinflüssen und genetischen Einflüssen, die stark unterschiedlich gewichtet sein können. In den vergangenen zwei Jahrzehnten sind die relativen Anteile genetischer Faktoren intensiv erforscht worden und haben zugleich wertvolle Einblicke in die Pathophysiologie einzelner Störungen gewährt. Neben der Weiterentwicklung von genetischen Techniken und Strategien zu deren Anwendung ist dabei das Augenmerk wieder vermehrt auf die klinische Beobachtungsgabe gerichtet worden. In der vorliegenden Übersicht werden bereits bewährte und neue Methoden der psychiatrischen Genetik vorgestellt und Ergebnisse bisheriger Arbeiten zu ausgewählten Störungen referiert.

Summary

The interplay of environmental and genetic factors accounts for marked variability in liability to psychiatric disorders. Over the past two decades, the relative contribution of genetic determinants has been the object of intense research and has offered valuable pathophysiological insights. While the advancement of techniques and strategies for gene finding has clearly benefitted psychiatric genetics, recent work has alerted to the importance of clinical judgement. The present review introduces to both established and future methods in the field, and summarizes data on the genetic backbone of selected psychiatric disorders.

Schlüsselwörter

Psychiatrische Genetik - Erblichkeit - familiäre Risiken

Keywords

Psychiatric genetics - heritability - familial risks

Full Text

References

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