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Arthritis und Rheuma 2017; 37(04): 239-246
DOI: 10.1055/s-0038-1626484
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Schattauer GmbH

Physiologie des Knochenmetabolismus und Knochenzell-Interaktionen

Physiology of bone metabolism and bone cell interactions
C. Biehl
1   Universitätsklinikum Gießen Marburg, Standort Gießen, Klinik und Poliklinik für Unfall-, Hand- und Wiederherstellungschirurgie – Operative Notaufnahme; Gießen
,
F. Merboth
2   Institut für Experimentelle Unfallchirurgie, Justus-Liebig Universität Gießen, Gießen
,
T. ElKassawna
1   Universitätsklinikum Gießen Marburg, Standort Gießen, Klinik und Poliklinik für Unfall-, Hand- und Wiederherstellungschirurgie – Operative Notaufnahme; Gießen
,
M. Rupp
1   Universitätsklinikum Gießen Marburg, Standort Gießen, Klinik und Poliklinik für Unfall-, Hand- und Wiederherstellungschirurgie – Operative Notaufnahme; Gießen
,
C. Heiß
1   Universitätsklinikum Gießen Marburg, Standort Gießen, Klinik und Poliklinik für Unfall-, Hand- und Wiederherstellungschirurgie – Operative Notaufnahme; Gießen
2   Institut für Experimentelle Unfallchirurgie, Justus-Liebig Universität Gießen, Gießen
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Further Information

Publication History

Publication Date:
12 January 2018 (online)

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Zusammenfassung

Die physiologischen Prozesse am Knochen unterliegen einem steten Wandel und hängen vom Zusammenspiel der verschiedenen Knochenzellen ab. Diese sind über komplexe Regulationsmechanismen miteinander verbunden. Osteoporosemodelle von Klein- und Großtieren ermöglichen das bessere Verständnis dieser Zusammenhänge. Die Schritte der Zellreifung und -differenzierung sind teilweise reversibel, um flexibel auf die Anforderungen reagieren zu können. Der Artikel stellt den aktuellen Stand der Zell-Zell-Interaktionen der Knochenregulation dar.

Summary

The physiological processes on the bone undergo a constant change and depend on the interaction of the different bone cells. These are linked by complex regulatory mechanisms. Osteoporosis models of small and large animals allow a better understanding of these mechanisms. Cell-maturation and -differentiation steps are partly reversible in order to be able to react flexibly to the requirements. The article presents the current status of cell-cell interactions in osteous regulation.

Schlüsselwörter

Knochenmetabolismus - Zell-Zell-Interaktion - Osteoporosemodell - Bone morphogenetic proteins - Knochenremodeling

Keywords

Bone metabolism - cell-cell interactions - osteoporosis models - bone morphogenetic proteins - bone remodeling
 

  • Literatur

  • 1 Marcus R, Feldman D, Nelson D, Rosen CJ. Fundamentals of Osteoporosis. Elsevier Science 2009
    Search in Google Scholar
  • 2 Halleen JM, Räisänen SR, Alatalo SL, Väänanen HK. Potential Function for the ROS-Generating Activity of TRACP. J Bone Miner Res 2003. 18 (10)
    Search in Google Scholar
  • 3 Xiong J, Piemontese M, Onal M. et al. Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone. PloS one 2015; 10 (09) e0138189
    CrossrefPubMedSearch in Google Scholar
  • 4 Gross TS, Edwards JL, McLeod KJ, Rubin CT. Strain Gradients Correlate with Sites of Periosteal Bone Formation. J Bone Miner Res 1997; 12 (06) 982-988.
    CrossrefPubMedSearch in Google Scholar
  • 5 Rubin CT, Lanyon LE. Kappa Delta Award paper. Osteoregulatory nature of mechanical stimuli: function as a determinant for adaptive remodeling in bone. Journal of orthopaedic research 1987; 5 (02) 300-310.
    CrossrefPubMedSearch in Google Scholar
  • 6 Frost HM. Bone‘s mechanostat: a 2003 update. Anat Rec A Discov Mol Cell Evol Biol 2003; 275 (02) 1081-1101.
    Search in Google Scholar
  • 7 Mori S, Burr DB. Increased intracortical remodeling following fatigue damage. Bone 1993; 14 (02) 103-109.
    CrossrefPubMedSearch in Google Scholar
  • 8 Heiss C, Govindarajan PS, Schlewitz G. et al. Induction of osteoporosis with its infuence on osteoporotic determinants and their interrelationships in rats by DEXA. Med Sci Monit 2012; 18 (06) 199-207.
    Search in Google Scholar
  • 9 Chambers TJ, Fuller K. Bone cells predispose bone surfaces to resorption by exposure of mineral to osteoclastic contact. J Cell Sci 1985; 76: 155-165.
    PubMedSearch in Google Scholar
  • 10 Parfitt AM. The mechanism of coupling: a role for the vasculature. Bone 2000; 26 (04) 319-323.
    CrossrefPubMedSearch in Google Scholar
  • 11 Parfitt AM. The Bone Remodeling Compartment: A Circulatory Function for Bone Lining Cells. J Bone Miner Res 2001; 16 (09) 1583-1585.
    CrossrefPubMedSearch in Google Scholar
  • 12 Parfitt AM. Osteonal and hemi-osteonal remodeling: the spatial and temporal framework for signal traffic in adult human bone. J Cell Biochem 1994; 55 (03) 273-286.
    CrossrefPubMedSearch in Google Scholar
  • 13 Merboth F. Enzym- und immunhistochemische Analyse des zellulären Knochenmetabolismus eines osteoporotischen Schafmodells. Gießen; Justus-Liebig-Universität: 2017
    Search in Google Scholar
  • 14 Lüllmann-Rauch R. Histologie. 3. ed.. Stuttgart, New York: Thieme; 2009
    Search in Google Scholar
  • 15 Garg AK. Mosby‘s Dental Dictionary. 3. ed.. Elsevier Health Sciences 2013
    Search in Google Scholar
  • 16 Lacey DL, Tan HL, Lu J. et al. Osteoprotegerin Ligand Modulates Murine Osteoclast Survival in Vitro and in Vivo. Am J Pathology 2000; 157 (02) 435-448.
    CrossrefPubMedSearch in Google Scholar
  • 17 Bull H, Murray P, Thomas D. et al. Acid phosphatases. J Clin Pathol Mol Pathol 2002; 55: 65-72.
    CrossrefPubMedSearch in Google Scholar
  • 18 Horwood NJ, Elliott J, Martin TJ, Gillespie MT. Osteotropic agents regulate the expression of osteoclast differentiation factor and osteoprotegerin in osteoblastic stromal cells. Endocrinology 1998; 139 (11) 4743-4746.
    CrossrefPubMedSearch in Google Scholar
  • 19 Gray C, Boyde A, Jones SJ. Topographically induced bone formation in vitro: implications for bone implants and bone grafts. Bone 1996; 18 (02) 115-123.
    CrossrefPubMedSearch in Google Scholar
  • 20 Wada T, Nakashima T, Hiroshi N, Penninger JM. RANKL-RANK signaling in osteoclastogenesis and bone disease. Trends Mol Med 2006; 12 (01) 17-25.
    CrossrefPubMedSearch in Google Scholar
  • 21 Burgess TL, Qian Y-x, Kaufman S. et al. The Ligand for Osteoprotegerin (OPGL) Directly Activates Mature Osteoclasts. J Cell Biology 1999; 145 (03) 527-538.
    CrossrefPubMedSearch in Google Scholar
  • 22 Simonet WS, Lacey DL, Dunstan CR. et al. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 1997; 89 (02) 309-319.
    CrossrefPubMedSearch in Google Scholar
  • 23 Kwon BS, Wang S, Udagawa N. et al. TR1, a new member of the tumor necrosis factor receptor superfamily, induces fibroblast proliferation and inhibits osteoclastogenesis and bone resorption. FASEB J 1998; 12 (10) 845-854.
    CrossrefPubMedSearch in Google Scholar
  • 24 Govindarajan P, Bocker W, El Khassawna T. et al. Bone matrix, cellularity, and structural changes in a rat model with high-turnover osteoporosis induced by combined ovariectomy and a multipledeficient diet. Am J Pathol 2014; 184 (03) 765-777.
    CrossrefPubMedSearch in Google Scholar
  • 25 Martin TJ, Sims NA. Osteoclast-derived activity in the coupling of bone formation to resorption. Trends Mol Med 2005; 11 (02) 76-81.
    CrossrefPubMedSearch in Google Scholar
  • 26 Brabant T. Die Verbindung von Muskel und Knochen unter besonderer Berücksichtigung des höheren Lebensalters. arthritis + rheuma 2015; 35: 212-216.
    Search in Google Scholar
  • 27 Pederson L, Ruan M, Westendorf JJ. et al. Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate. Proceedings of the National Academy of Sciences of the United States of America 2008; 105 (52) 20764-20769.
    CrossrefPubMedSearch in Google Scholar
  • 28 Ryu J, Kim HJ, Chang E-J. et al. Sphingosine 1-phosphate as a regulator of osteoclast differentiation and osteoclast– osteoblast coupling. The EMBO Journal 2006; 25: 5840-5851.
    CrossrefPubMedSearch in Google Scholar
  • 29 Martin TJ. Parathyroid Hormone-Related Protein, Its Regulation of Cartilage and Bone Development, and Role in Treating Bone Diseases. Physiol Rev 2016; 96 (03) 831-871.
    CrossrefPubMedSearch in Google Scholar
  • 30 Miao D, He B, Jiang Y. et al. Osteoblast-derived PTHrP is a potent endogenous bone anabolic agent that modifies the therapeutic efficacy of administered PTH 1-34. J Clin Invest 2005; 115 (09) 2402-2411.
    CrossrefPubMedSearch in Google Scholar
  • 31 Sharifi M, Ereifej L, Lewiecki EM. Sclerostin and skeletal health. Rev Endocr Metab Disord 2015; 16 (02) 149-156.
    CrossrefPubMedSearch in Google Scholar
  • 32 Peterlik M. Wnt-Signalwege im Knochenstoffwechsel. Osteologie 2011; 20 (03) 197-202.
    Thieme ConnectSearch in Google Scholar
  • 33 Lerner UH, Ohlsson C. The WNT system: background and its role in bone. J Intern Med 2015; 277 (06) 630-649.
    CrossrefPubMedSearch in Google Scholar
  • 34 Golub EE. Role of Matrix Vesicles in Biomineralization. Biochim Biophys Acta 2009; 1790 (12) 1592-1598.
    CrossrefPubMedSearch in Google Scholar
  • 35 Anderson HC, Sipe JB, Hessle L. et al. Impaired Calcification Around Matrix Vesicles of Growth Plate and Bone in Alkaline Phosphatase- Deficient Mice. Am J of Pathology 2004. 164 (3)
    Search in Google Scholar
  • 36 Millan JL. The role of phosphatases in the initiation of skeletal mineralization. Calcif Tissue Int 2013; 93 (04) 299-306.
    CrossrefPubMedSearch in Google Scholar
  • 37 Hessle L, Johnson K, Anderson H. et al. Tissuenonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization. Proceedings of the National Academy of Sciences of the United States of America 2002; 99 (14) 9445-9449.
    CrossrefPubMedSearch in Google Scholar
  • 38 Carano A, Schlesinger PH, Athanasou NA. et al. Acid and base effects on avian osteoclast activity. Am J Physiol 1993; 264 (3 Pt 1) C694-C701.
    CrossrefPubMedSearch in Google Scholar
  • 39 Vaananen HK, Zhao H, Mulari M, Halleen JM. The cell biology of osteoclast function. J Cell Sci 2000; 113 (03) 377-381.
    PubMedSearch in Google Scholar
  • 40 Salo J, Lehenkari P, Mulari M. et al. Removal of osteoclast bone resorption products by transcytosis. Science 1997; 276 5310 270-273.
    CrossrefPubMedSearch in Google Scholar
  • 41 Ljusberg J, Ek-Rylander B, Andersson G. Tartrateresistant purple acid phosphatase is synthesized as a latent proenzyme and activated by cysteine proteinases. Biochem J 1999; 343 (01) 63-69.
    CrossrefPubMedSearch in Google Scholar
  • 42 van der Eerden BC, Hoenderop JG, de Vries TJ. et al. The epithelial Ca2+ channel TRPV5 is essential for proper osteoclastic bone resorption. Proceedings of the National Academy of Sciences of the United States of America 2005; 102 (48) 17507-17512.
    CrossrefPubMedSearch in Google Scholar