Die Bedeutung neurobiologischer Faktoren bei der Aggressionsgenese II

J. L. Müller

doi:10.1055/s-0038-1626806

Nervenheilkunde, Table of Contents

Nervenheilkunde 2006; 25(11): 962-967
DOI: 10.1055/s-0038-1626806

Original- und Übersichtsarbeiten - Original and Review Articles

Schattauer GmbH

Die Bedeutung neurobiologischer Faktoren bei der Aggressionsgenese II

Neuroanatomische und neurofunktionelle AspekteThe impact of neuro-biological factors in the genesis of violence IIneuro-anatomical and neuro-functinal aspects

J. L. Müller

¹Abteilung für Forensische Psychiatrie und Psychotherapie im Niedersächsischen Landeskrankenhaus, Georg August Universität Göttingen

› Author Affiliations

Abstract

Zusammenfassung

Einer Vielzahl neurochemischer Faktoren, neuroanatomischer Strukturen und neurofunktioneller Veränderungen werden eine Bedeutung bei der Genese aggressiver Handlungen zugeschrieben. Kasuistiken über Patienten mit Hirnverletzungen, Aktivierungsuntersuchungen mit gesunden Probanden sowie Studien mit Straftätern belegen die Bedeutung insbesondere frontaler und temporaler Hirnregionen bei der Aggressionsgenese. Im Folgenden wird eine Übersicht über die vorliegenden neuroanatomischen Befunde und neurofunktionellen Veränderungen bei der Aggressionsgenese gegeben. Zusammenfassend wird auf die neurobiologische Perspektive von Therapie und Prävention aggressiver Handlungen eingegangen.

Summary

Neurobiology of violence and aggression is poorly understood. Case reports on patients with brain injuries, studies on controls as well as on criminals helped to illustrate the impact of in particular frontal and temporal brain regions on aggression. The following article gives an overview on recent findings on neuro-anatomical underpinnings and neuro-functional changes in aggressive behavior. Finally,a neuro-biological perspective on therapy and prevention of aggressive behaviour is given.

Schlüsselwörter

Aggression - PFC - Amygdala - temporaler Kortex - “Psychopathy”

Keywords

Aggression - PFC - amygdala - temporal cortex - „Psychopathy“

Full Text

References

Literatur
1 Armenteros JL, Lewis JE. Citalopram treatment for impulsive aggression in children and adolescents: an open pilot study. J Am Acad Child Adolesc Psychiatry 2002; 41: 522-9.
2 Bassarath L. Neuroimaging studies of antisocial behaviour: Can. J Psychiatry 2001; 46: 728-32.
3 Bigler ED. Frontal lobe pathology and antisocial personality disorder. Arch Gen Psychiatry 2001; 58: 609-11.
4 Biver F, Lotstra F, Monclus M, Wikler D, Damhaut P, Mendlewicz J, Goldman S. Sex difference in 5HT2 receptor in the living human brain. Neurosci Lett 1996; 204: 25-8.
5 Blair RJ. Neurobiological basis of psychopathy. Br J Psychiatry 2003; 182: 5-7.
6 Blair RJ, Cipolotti L. Impaired social response reversal. A case of ‘acquired sociopathy’. Brain 2000; 123: 1122-41.
7 Blair RJ, Mitchell DG, Richell RA, Kelly S, Leonard A, Newman C, Scott SK. Turning a deaf ear to fear: impaired recognition of vocal affect in psychopathic individuals. J Abnorm Psychol 2002; 111: 682-6.
8 Carr L, Iacoboni M, Dubeau MC, Mazziotta JC, Lenzi GL. Neural mechanisms of empathy in humans: a relay from neural systems for imitation to limbic areas. Proc Natl Acad Sci USA 2003; 100: 5497-502.
9 Cases O, Seif I, Grimsby J, Gaspar P, Chen K, Pournin S, Muller U, Aguet M, Babinet C, ShihJ C. Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. Science 1995; 268: 1763-6.
10 Cherek DR, Lane SD. Effects of d,l-fenfluramine on aggressive and impulsive responding in adult males with a history of conduct disorder. Psychopharmacology (Berl) 1999; 146: 473-81.
11 Cherek DR, Lane SD. Acute effects of D-fenfluramine on simultaneous measures of aggressive escape and impulsive responses of adult males with and without a history of conduct disorder. Psychopharmacology (Berl) 2001; 157: 221-7.
12 Cherek DR, Lane SD, Pietras CJ, Steinberg JL. Effects of chronic paroxetine administration on measures of aggressive and impulsive responses of adult males with a history of conduct disorder. Psychopharmacology (Berl) 2002; 159: 266-74.
13 Coccaro EF, Kavoussi RJ. Fluoxetine and impulsive aggressive behavior in personality-disordered subjects. Arch Gen Psychiatry 1997; 54: 1081-8.
14 Coccaro EF, Kavoussi RJ, Cooper TB, Hauger R. Central serotonin activity and aggression: inverse relationship with prolactin response to d-fenfluramine, but not CSF 5-HIAA concentration, in human subjects. Am J Psychiatry 1997; 154: 1430-5.
15 Coccaro EF, Kavoussi RJ, Hauger RL. Serotonin function and antiaggressive response to fluoxetine: a pilot study. Biol Psychiatry 1997; 42: 546-52.
16 Constantino JN, Liberman M, Kincaid M. Effects of serotonin reuptake inhibitors on aggressive behavior in psychiatrically hospitalized adolescents: results of an open trial. J Child Adolesc Psychopharmacol 1997; 07: 31-44.
17 Daffner KR, Mesulam MM, Scinto LF, Acar D, Calvo V, Faust R, Chabrerie A, Kennedy B, Holcomb P. The central role of the prefrontal cortex in directing attention to novel events. Brain 2000; 123: 927-39.
18 Damasio AR. On some functions of the human prefrontal cortex. Ann NY Acad Sci 1995; 769: 241-51.
19 Damasio AR. The somatic marker hypothesis and the possible functions of the prefrontal cortex. Philos Trans R Soc Lond B Biol Sci 1996; 351: 1413-20.
20 Damasio H, Grabowski T, Frank R, Galaburda AM, Damasio AR. The return of Phineas Gage: clues about the brain from the skull of a famous patient. Science 1994; 264: 1102-5.
21 Davidson RJ, Putnam KM, Larson CL. Dysfunction in the neural circuitry of emotion regulation--a possible prelude to violence. Science 2000; 289: 591-4.
22 Decety J, Chaminade T. Neural correlates of feeling sympathy. Neuropsychologia 2003; 41: 127-38.
23 Dolan M. What neuroimaging tells us about psychopathic disorders. Hosp.Med 2002; 63: 337-40.
24 Dolan M, Anderson IM, Deakin JF. Relationship between 5-HT function and impulsivity and aggression in male offenders with personality disorders. Br J Psychiatry 2001; 178: 352-9.
25 Dolan M, Deakin WJ, Roberts N, Anderson I. Serotonergic and cognitive impairment in impulsive aggressive personality disordered offenders: are there implications for treatment?. Psychol Med 2002; 32: 105-17.
26 Farrow TF, Zheng Y, Wilkinson ID, Spence SA, Deakin JF, Tarrier N, Griffiths PD, Woodruff PW. Investigating the functional anatomy of empathy and forgiveness. Neuroreport 2001; 12: 2433-8.
27 Fergusson D, Doucette S, Glass K C, Shapiro S, Healy D, Hebert P, Hutton B. Association between suicide attempts and selective serotonin reuptake inhibitors: systematic review of randomised controlled trials. BMJ 2005; 330: 396.
28 Fernandez M, Pissiota A, Frans O, von Knorring L, Fischer H, Fredrikson M. Brain function in a patient with torture related post-traumatic stress disorder before and after fluoxetine treatment: a positron emission tomography provocation study. Neurosci Lett 2001; 297: 101-4.
29 Garza-Trevino ES. Neurobiological factors in aggressive behavior. Hosp.Community Psychiatry 1994; 45: 690-9.
30 Geday J, Gjedde A, Boldsen AS, Kupers R. Emotional valence modulates activity in the posterior fusiform gyrus and inferior medial prefrontal cortex in social perception. Neuroimage 2003; 18: 675-84.
31 Gogos JA, Morgan M, Luine V, Santha M, Ogawa S, Pfaff D, Karayiorgou M. Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior. Proc Natl Acad Sci USA 1998; 95: 9991-6.
32 Grafman J, Schwab K, Warden D, Pridgen A, Brown HR, Salazar AM. Frontal lobe injuries, violence, and aggression: a report of the Vietnam Head Injury Study. Neurology 1996; 46: 1231-8.
33 Greendyke RM, Kanter DR. Therapeutic effects of pindolol on behavioral disturbances associated with organic brain disease: a double-blind study. J Clin Psychiatry 1986; 47: 423-6.
34 Greendyke RM, Kanter DR, Schuster DB, Verstreate S, Wootton J. Propranolol treatment of assaultive patients with organic brain disease. A double-blind crossover, placebo-controlled study. J Nerv Ment Dis 1986; 174: 290-4.
35 Gunnell D, Saperia J, Ashby D. Selective serotonin reuptake inhibitors (SSRIs) and suicide in adults: meta-analysis of drug company data from placebo controlled, randomised controlled trials submitted to the MHRA’s safety review. BMJ 2005; 330: 385.
36 Hadi F, Franco K, Hermida T, Douton K, Zarko R. Citalopram for impulsive aggression. J Am Acad Child Adolesc Psychiatry 2003; 42: 749-50.
37 Hare RD. Psychopathy asa risk factor for violence. Psychiatr Q 1999; 70: 181-97.
38 Hare RD, Clark D, Grann M, Thornton D. Psychopathy and the predictive validity of the PCL-R: an international perspective. Behav Sci Law 2000; 18: 623-45.
39 Holden C. Neuroscience. Imaging studies show how brain thinks about pain. Science 2004; 303: 1121.
40 Kavoussi RJ, Coccaro EF. Divalproex sodium for impulsive aggressive behavior in patients with personality disorder. J.Clin.Psychiatry 1998; 59: 676-80.
41 Kavoussi RJ, Liu J, Coccaro EF. An open trial of sertraline in personality disordered patients with impulsive aggression. J Clin Psychiatry 1994; 55: 137-41.
42 Kiehl KA, Smith AM, Hare RD, Mendrek A, Forster BB, Brink J, Liddle PF. Limbic abnormalities in affective processing by criminal psychopaths as revealed by functional magnetic resonance imaging. Biol Psychiatry 2001; 50: 677-84.
43 Kiloh LG, Gye RS, Rushworth RG, Bell DS, White RT. Stereotactic amygdaloidotomy for aggressive behaviour. J Neurol Neurosurg Psychiatry 1974; 37: 437-44.
44 Kiloh LG, Smith JS. The neural basis of aggression and its treatment by psychosurgery. Aust NZJ Psychiatry 1978; 12: 21-8.
45 Knutson B, Cole S, Wolkowitz O, Reus V, Chan T, Moore E. Serotonergic intervention increases affiliative behavior in humans. Ann NY Acad Sci 1997; 807: 492-3.
46 Knutson B, Wolkowitz OM, Cole SW, Chan T, Moore EA, Johnson RC, Terpstra J, Turner RA, Reus VI. Selective alteration of personality and social behavior by serotonergic intervention. Am J Psychiatry 1998; 155: 373-9.
47 Kunz M, Sikora J, Krakowski M, Convit A, Cooper T B, Volavka J. Serotonin in violent patients with schizophrenia. Psychiatry Res 1995; 59: 161-3.
48 Laakso MP, Gunning-Dixon F, Vaurio O, RepoTiihonen E, Soininen H, Tiihonen J. Prefrontal volumes in habitually violent subjects with antisocial personality disorder and type 2 alcoholism. Psychiatry Res 2002; 114: 95-102.
49 Laakso MP, Vaurio O, Koivisto E, Savolainen L, Eronen M, Aronen H J, Hakola P, Repo E, Soininen H, Tiihonen J. Psychopathy and the posterior hippocampus. Behav Brain Res 2001; 118: 187-93.
50 Lappalainen J, Long JC, Eggert M, Ozaki N, Robin RW, Brown GL, Naukkarinen H, Virkkunen M, Linnoila M, Goldman D. Linkage of antisocial alcoholism to the serotonin 5-HT1B receptor gene in 2 populations. Arch Gen Psychiatry 1998; 55: 989-94.
51 Lee GP, Bechara A, Adolphs R, Arena J, MeadorK J, Loring DW, Smith JR. Clinical and physiological effects of stereotaxic bilateral amygdalotomy for intractable aggression. J Neuropsychiatry Clin Neurosci 1998; 10: 413-20.
52 Lee R, Coccaro E. The neuropsychopharmacology of criminality and aggression. Can J Psychiatry 2001; 46: 35-44.
53 Leslie KR, Johnson-Frey SH, Grafton ST. Functional imaging of face and hand imitation: towards a motor theory of empathy. Neuroimage 2004; 21: 601-7.
54 Macmillan M. Inhibition and the control of behavior. From Gall to Freud via Phineas Gage and the frontal lobes. Brain Cogn 1992; 19: 72-104.
55 Mann JJ. The neurobiology of suicide. Nat Med 1998; 04: 25-30.
56 Marini JL, Sheard MH. Antiaggressive effect of lithium ion in man. Acta Psychiatr Scand 1977; 55: 269-86.
57 Mark VH, Sweet WH. The role of limbic brain dysfunction in aggression. Res Publ Assoc Res Nerv Ment Dis 1974; 52: 186-200.
58 Mattes JA. Carbamazepine for uncontrolled rage outbursts. Lancet 1984; 02: 1164-5.
59 Mattes JA. Propranolol for adults with temper outbursts and residual attention deficit disorder. J Clin Psychopharmacol 1986; 06: 299-302.
60 Mattes JA. Psychopharmacology of temper outbursts. A review. J Nerv Ment Dis 1986; 174: 464-70.
61 Mattes JA. Carbamazepine vs. propranolol for rage outbursts. Psychopharmacol Bull 1988; 24: 179-82.
62 Müller JL, Schuierer G, Marienhagen J, Putzhammer A, Klein HE. “Acquired Psychopathy” and the Neurobiology of Emotion and Violence. Psychiatr Prax 2003; 30: 221-5.
63 Müller JL, Sommer M, Wagner V, Lange K, Taschler H, Roder CH, Schuierer G, Klein HE, Hajak G. Abnormalities in emotion processing within cortical and subcortical regions in criminal psychopaths: evidence from a functional magnetic resonance imaging study using pictures with emotional content. Biol Psychiatry 2003; 54: 152-62.
64 New AS, Hazlett EA, Buchsbaum MS, Goodman M, Reynolds D, Mitropoulou V, Sprung L, Shaw Jr RB, Koenigsberg H, Platholi J, Silverman J, Siever LJ. Blunted prefrontal cortical 18fluorodeoxyglucose positron emission tomography response to meta-chlorophenylpiperazine in impulsive aggression. Arch Gen Psychiatry 2002; 59: 621-9.
65 Nolan KA, Volavka J, Mohr P, Czobor P. Psychopathy and violent behavior among patients with schizophrenia or schizoaffective disorder. Psychiatr Serv 1999; 50: 787-92.
66 Pietrini P, Guazzelli M, Basso G, Jaffe K, Grafman J. Neural correlates of imaginal aggressive behavior assessed by positron emission tomography in healthy subjects. Am J Psychiatry 2000; 157: 1772-81.
67 Raine A, Buchsbaum MS, Stanley J, Lottenberg S, Abel L, Stoddard J. Selective reductions in prefrontal glucose metabolism in murderers. Biol Psychiatry 1994; 36: 365-73.
68 Raine A, Lencz T, Taylor K, Hellige JB, Bihrle S, LaCasse L, Lee M, Ishikawa S, Colletti P. Corpus callosum abnormalities in psychopathic antisocial individuals. Arch Gen Psychiatry 2003; 60: 1134-42.
69 Raine A, Phil D, Stoddard J, Bihrle S, Buchsbaum L. Prefrontal glucose deficits in murderers lacking psychosocial deprivation. Neuropsychiatry Neuropsychol Behav Neurol 1998; 11: 1-7.
70 Reist C, Nakamura K, Sagart E, Sokolski KN, Fujimoto KA. Impulsive aggressive behavior: openlabel treatment with citalopram. J Clin Psychiatry 2003; 64: 81-5.
71 Sachdev P, Smith JS, Matheson J, Last P, Blumbergs P. Amygdalo-hippocampectomy for pathological aggression. Aust N Z J Psychiatry 1992; 26: 671-6.
72 Shamay SG, Tomer R, Aharon-Peretz J. Deficit in understanding sarcasm in patients with prefronal lesion is related to impaired empathic ability. Brain Cogn 2002; 48: 558-63.
73 Sheard MH. The effect of lithium and other ions on aggressive behavior. Mod.Probl.Pharmacopsychiatry 1978; 13: 53-68.
74 Seard MH, Marini JL, Bridges CI, Wagner E. The effect of lithium on impulsive aggressive behavior in man. Am J Psychiatry 1976; 133: 1409-13.
75 Snoek H, van Goozen SH, Matthys W, SiglingH O, Koppeschaar HP, Westenberg HG, van Engeland H. Serotonergic functioning in children with oppositional defiant disorder: a sumatriptan challenge study. Biol Psychiatry 2002; 51: 319-25.
76 Soderstrom H, Hultin L, Tullberg M, Wikkelso C, Ekholm S, Forsman A. Reduced frontotemporal perfusion in psychopathic personality. Psychiatry Res 2002; 114: 81-94.
77 Staner L, Mendlewicz J. Heredity and role of serotonin in aggressive impulsive behavior. Encephale 1998; 24: 355-364.
78 Tonkonogy JM. Violence and temporal lobe lesion: head CT and MRI data. J Neuropsychiatry Clin Neurosci 1991; 03: 189-96.
79 van Elst LT, Trimble MR, Ebert D, van Elst LT. Dual brain pathology in patients with affective aggressive episodes. Arch.Gen.Psychiatry 2001; 58: 1187-8.
80 Volavka J. The neurobiology of violence: an update. J. Neuropsychiatry Clin Neurosci 1999; 11: 307-14.
81 Vollm B, Richardson P, Stirling J, Elliott R, Dolan M, Chaudhry I, Del Ben C, McKie S, Anderson I, Deakin B. Neurobiological substrates of antisocial and borderline personality disorder: preliminary results ofa functional fMRI study. Crim Behav Ment Health 2004; 14: 39-54.
82 Walsh MT, Dinan TG. Selective serotonin reuptake inhibitors and violence: a review of the available evidence. Acta Psychiatr Scand 2001; 104: 84-91.