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Nervenheilkunde 2006; 25(12): 1039-1045
DOI: 10.1055/s-0038-1626817
Original- und Übersichtsarbeiten - Original and Review Articles
Schattauer GmbH

Wirksamkeit und Sicherheit von Rivastigmin bei Patienten mit Demenz unter Praxisbedingungen

Efficacy and safety of rivastigmine in patients with dementia in practice
W. Retz
1   Institut für Gerichtliche Psychologie und Psychiatrie der Universität des Saarlandes, Homburg/Saar, Nürnberg
,
F. Tracik
2   Medizinische Abteilung, Novartis Pharma AG, Nürnberg
,
M. Rösler
1   Institut für Gerichtliche Psychologie und Psychiatrie der Universität des Saarlandes, Homburg/Saar, Nürnberg
› Author Affiliations
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Publication History

Publication Date:
19 January 2018 (online)

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Zusammenfassung

Das Ziel dieser offenen, prospektiven Beobachtungsstudie war es, den klinischen Verlauf von Patienten mit Demenz unter der Therapie mit Rivastigmin, einem Azetylcholinund Butyrylcholinesterasehemmstoff, unter Praxisbedingungen zu untersuchen.

867 Ärzte in Arztpraxen, Ambulanzen und Memory-Kliniken rekrutierten 1 214 Demenzpatienten, von denen 75% leicht bis mittelgradig (Mini-Mental-State-Test ≥ 10) und 25% schwergradig ausgeprägte Symptome aufwiesen. Die Patienten erhielten Rivastigminlösung peroral in einer durchschnittlichen Tagesdosierung von 6,7 mg über4 Monate.

Unter Rivastigmin besserten sich die Patienten in allen untersuchten Symptombereichen (Gedächtnis-, Sprach-, Orientierungs-, Verhaltensund Alltagskompentenzstörungen) signifikant (p < 0,05). Bei Patienten mit schwergradiger Demenz war der therapeutische Effekt von Rivastigmin am stärksten ausgeprägt. Die Verträglichkeit von Rivastigmin wurde von 93,2% der behandelnden Ärzte als gut oder sehr gut beurteilt.

Rivastigmin zeigte bei Patienten mit leicht bis schwergradiger Demenz unter Praxisbedingungen eine klinisch relevante Wirksamkeit und gute Verträglichkeit.

Summary

The aim of the present observational open study was to investigate prospectively the clinical effects of rivastigmine, an inhibitor of acetylcholinesterase as well as butyrylcholinesterase, on the course of patients with dementia under “real life” practice conditions.

867 physicians in primary care settings and memory clinics included 1 214 patients with dementia of whom 75% had mild to moderate (Mini Mental State Examination ≥ 10)

and 25% severe symptoms. Rivastigmine solution was administered orally at an average daily dose of 6.7 mg over4 months.

All investigated symptoms (disturbances of memory, speech, orientation, behaviour and capability of daily living) significantly improved during treatment with rivastigmine (p< 0.05). The therapeutic effect of rivastigmine was most pronounced in patients with severe dementia. 93.2% of the treating physicians judged the tolerability of rivastigmine to be good or very good.

Rivastigmine revealed clinical relevant efficacy and was tolerated well by patients with mild to severe dementia.

Schlüsselwörter

Rivastigmin - Demenz - Wirksamkeit - Verträglichkeit - Praxisbedingungen

Keywords

Rivastigmine - dementia - efficacy - tolerability - “real life” practice conditions
 

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