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Nervenheilkunde 2007; 26(09): 759-762
DOI: 10.1055/s-0038-1626922
Original Article
Schattauer GmbH

Aktuelle Aspekte der Rolle des Gehirns beim Diabetes mellitus

Das Gehirn als (Mit-)TäterCurrent aspects of the role of the brain in diabetes mellitusthe brain as a culprit
F. Erbguth
1   Klinik für Neurologie, Klinikum Nürnberg Süd (Leitender Arzt: Prof. Dr. med. Dipl.-Psych. F. Erbguth)
,
W. Dietrich
1   Klinik für Neurologie, Klinikum Nürnberg Süd (Leitender Arzt: Prof. Dr. med. Dipl.-Psych. F. Erbguth)
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Further Information

Publication History

Eingegangen am: 19 March 2007

Publication Date:
20 January 2018 (online)

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Zusammenfassung

Neuere Erkenntnisse und pathogenetische Modelle zur Wirkung von Glukose, Insulin und Leptin am Gehirn einschließlich einer zerebralen Insulinresistenz unterstreichen die Rolle des Gehirns nicht nur als “Opfer” des Diabetes, sondern auch als (Mit-)Täter im komplexen metabolischen Geschehen beim Diabetes. Insulin könnte über eine Konkurrenz mit dem Beta-Amyloid abbauenden “Insulin-Degrading-Enzyme” (IDE) in die Pathophysiologie der Alzheimer-Demenz verwickelt sein.

Summary

Recent insights and proposed pathophysiological mechanisms concerning the effects of glucose, insulin, and leptin on the brain including cerebral insulin resistance suggest a role of the brain not only as “victim” of diabetes, but also as a “culprit” in the complex metabolic disturbances of diabetes.

Schlüsselwörter

Diabetes mellitus - Gehirn - Demenz - Depression

Keywords

Diabetes mellitus - brain - dementia - depression
 

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