Nervenheilkunde, Table of Contents

Nervenheilkunde 2007; 26(10): 853-860
DOI: 10.1055/s-0038-1626936

Arbeiten zum Schwerpunkt - Theme Articles

Schattauer GmbH

Neurochemische Frühdiagnostik und klinische Neuroproteomik demenzieller Erkrankungen

Neurochemical early diagnostic and clinical neuroproteomik in dementia diseases

J. Wiltfang

¹Klinik mit Poliklinik für Psychiatrie und Psychotherapie, Universität Erlangen-Nürnberg

,

M. Bibl

²Klinik für Psychiatrie und Psychotherapie der Rheinischen Kliniken Essen, Universität Duisburg-Essen

,

M. Maler

¹Klinik mit Poliklinik für Psychiatrie und Psychotherapie, Universität Erlangen-Nürnberg

,

H.-W. Klafki

¹Klinik mit Poliklinik für Psychiatrie und Psychotherapie, Universität Erlangen-Nürnberg

,

H. Esselmann

¹Klinik mit Poliklinik für Psychiatrie und Psychotherapie, Universität Erlangen-Nürnberg

,

J. Kornhuber

¹Klinik mit Poliklinik für Psychiatrie und Psychotherapie, Universität Erlangen-Nürnberg

,

P. Lewczuk

¹Klinik mit Poliklinik für Psychiatrie und Psychotherapie, Universität Erlangen-Nürnberg

› Author Affiliations

Zusammenfassung

Die vorliegende Arbeit soll eine Übersicht über das sich schnell entwickelnde Gebiet der Neurochemischen Demenzdiagnostik (NDD) geben, wobei der Schwerpunkt auf Anwendungen liegen soll, die zwischenzeitlich bereits Eingang in die Routinediagnostik gefunden haben oder wo dies bald zu erwarten ist. Demenzbiomarker, die in unabhängigen größeren Studien multizentrisch an mehreren tausend Patienten und Probanden validiert wurden, liegen bisher nur für folgende Parameter im lumbalen Liquor vor (liquorbasierte neurochemische Demenzdiagnostik, LiquorNDD): beta-Amyloidpeptide, Gesamt-Tau und hyperphosphorylierte Tau-Proteine (phospho-Tau). Diese Studien belegen eindrucksvoll, dass die CSF-NDD zwischenzeitlich eine hohe Relevanz für die verbesserte Frühund Differenzialdiagnostik demenzieller Erkrankungen erlangt hat und für die Alzheimer-Demenz eine prädiktive Diagnostik bietet.

Summary

This article summarises the current achievements in neurochemical dementia diagnostics (NDD) with special emphasis on applications which have already been introduced into routine diagnostics or which are expected to be introduced shortly. Based on independent multi center studies with several thousands of patients the following neurochemical dementia markers have been validated in cerebrospinal fluid (CSF-NDD): beta-amyloid peptides, total tau and hyperphosphorylated tau proteins (phospho-tau). These studies clearly show that CSF-NDD is of high clinical relevance for the improved early and differential diagnosis of dementias and that it also does offer a diagnostic tool for the predictive diagnosis of incipient Alzheimer’s dementia.

Schlüsselwörter

Schlüsselwörter

Alzheimer-Demenz - Liquor zerebrospinalis - Biomarker - Tau-Protein - Amyloidpeptid - beta-Amyloidpeptid - klinische Neurochemie

Keywords

Keywords

Alzheimer’s Dementia - cerebrospinal fluid - biomarkers - tau - amyloid - beta-amyloid peptides - clinical neurochemistry

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