Schmerzforschung mit der Positronen-Emissions-Tomografie

T. Sprenger; T.R. Tölle; H. Boecker; P. Bartenstein

doi:10.1055/s-0038-1627141

Nervenheilkunde, Table of Contents

Nervenheilkunde 2009; 28(10): 733-738
DOI: 10.1055/s-0038-1627141

Nuklearmedizinische Bildgebung

Schattauer GmbH

Schmerzforschung mit der Positronen-Emissions-Tomografie

Pain research with positron emission tomography

Authors

T. Sprenger

¹Department of Neurology, Headache Group, University of California, San Francisco

²Neurologische Klinik und Poliklinik, TU München
T.R. Tölle

²Neurologische Klinik und Poliklinik, TU München
H. Boecker

³FE Klinische Funktionelle Neurobildgebung, Radiologische Universitätsklinik, Friedrich-Wilhelms- Universität Bonn
P. Bartenstein

⁴Klinik und Poliklinik für Nuklearmedizin, LMU München

Abstract

Zusammenfassung

Im Rahmen der Schmerzforschung mit der Positronen- Emissions-Tomografie (PET) sind in den letzten Jahren zahlreiche wegweisende Arbeiten entstanden, welche unser heutiges Verständnis der zerebralen Schmerzverarbeitung und Schmerzmodulation wesentlich geprägt haben. In dieser Übersichtsarbeit fassen wir wichtige PET-Befunde zur Physiologie der Schmerzverarbeitung und des Opioidsystems sowie zur Pathophysiologie von ausgewählten Schmerzsyndromen zusammen und erörtern welche zukünftigen Entwicklungen zu erwarten sind.

Summary

Studies applying positron emission tomography (PET) have tremendously advanced our understanding of cerebral pain processing as well as pain modulation in the past. This article summarizes key findings on the physiology of cerebral pain processing and the opioid system as well as the pathophysiology of selected clinical pain conditions. We also outline the future potential of PET in pain research.

Schlüsselwörter

PET - Aktivierung - Metabolismus - Liganden - Opiate - Schmerz

Keywords

PET - activation - metabolism - ligand - opiate - pain

Full Text

References

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