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Nervenheilkunde 2011; 30(11): 863-869
DOI: 10.1055/s-0038-1628438
DOI: 10.1055/s-0038-1628438
Depression
Neurobiologie der bipolaren Störungen
Neurobiology of bipolar disordersFurther Information
Publication History
Eingegangen am:
01 July 2011
angenommen am:
29 July 2011
Publication Date:
22 January 2018 (online)
Zusammenfassung
Die biologische Forschung hat in den letzten Jahren wertvolle Erkenntnisse über die Ursachen der bipolaren Störung geliefert. Studien über neurochemische und molekularbiologische Veränderungen im Gehirn, strukturelle Auffälligkeiten aber auch eine Vielzahl genetischer Untersuchungen konnten dabei das Wissen zur bestehenden Annahme einer multifaktoriellen Genese vertiefen. Der Einfluss psychosozialer Faktoren und neuropsychologischer Parameter stehen im Mittelpunkt des Forschungsinteresses. Im folgenden Artikel werden die wesentlichen neurobiologischen Forschungsergebnisse der letzten Jahre zusammengefasst. Dabei liegt der Schwerpunkt auf molekularbiologischen und hirnmorphologischen Veränderungen, die die Grundlage weiterer erfolgversprechender Ansätze zukünftiger Forschung darstellen.
Summary
In recent years, neurobiological research in the development of bipolar disorder has contributed to a number of important findings. Studies of neurochemical and molecular-biological changes in the brain, structural abnormalities as well as a variety of genetic investigations have consolidated the current view of a multifactorial genesis. A further focus has been on the influence of psychosocial factors and neuropsychological parameters in the development of bipolar disorder. The following article describes key findings from recent research on neurobiological and psychosocial factors in the development of bipolar disorder with a focus on molecular-biological and structural brain changes which represent the basis for future successful approaches in prospective research.
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