Neurobiologie der bipolaren Störungen

U. Lewitzka; M. Bauer

doi:10.1055/s-0038-1628438

Nervenheilkunde, Table of Contents

Nervenheilkunde 2011; 30(11): 863-869
DOI: 10.1055/s-0038-1628438

Depression

Schattauer GmbH

Neurobiologie der bipolaren Störungen

Neurobiology of bipolar disorders

U. Lewitzka

¹Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinikum Carl Gustav Carus, Dresden

²Dalhousie University, Department of Psychiatry, Flourish Mood Disorders, IWK Health Centre, Halifax, Kanada

,

M. Bauer

¹Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinikum Carl Gustav Carus, Dresden

› Author Affiliations

Abstract

Zusammenfassung

Die biologische Forschung hat in den letzten Jahren wertvolle Erkenntnisse über die Ursachen der bipolaren Störung geliefert. Studien über neurochemische und molekularbiologische Veränderungen im Gehirn, strukturelle Auffälligkeiten aber auch eine Vielzahl genetischer Untersuchungen konnten dabei das Wissen zur bestehenden Annahme einer multifaktoriellen Genese vertiefen. Der Einfluss psychosozialer Faktoren und neuropsychologischer Parameter stehen im Mittelpunkt des Forschungsinteresses. Im folgenden Artikel werden die wesentlichen neurobiologischen Forschungsergebnisse der letzten Jahre zusammengefasst. Dabei liegt der Schwerpunkt auf molekularbiologischen und hirnmorphologischen Veränderungen, die die Grundlage weiterer erfolgversprechender Ansätze zukünftiger Forschung darstellen.

Summary

In recent years, neurobiological research in the development of bipolar disorder has contributed to a number of important findings. Studies of neurochemical and molecular-biological changes in the brain, structural abnormalities as well as a variety of genetic investigations have consolidated the current view of a multifactorial genesis. A further focus has been on the influence of psychosocial factors and neuropsychological parameters in the development of bipolar disorder. The following article describes key findings from recent research on neurobiological and psychosocial factors in the development of bipolar disorder with a focus on molecular-biological and structural brain changes which represent the basis for future successful approaches in prospective research.

Schlüsselwörter

Neurobiologie - bipolare Störung - molekularbiologische Veränderungen - hirnstrukturelle Auffälligkeiten - genetische Disposition

Keywords

Neurobiology - bipolar disorder - molecular-biological changes - structural brain abnormalities - genetic disposition

Full Text

References

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