Superselektive arterielle Spinmarkierung

Zusammenfassung

Gegenstand und Ziel: Sind superselektive ASL-Angiografie- und Perfusionsmessungen bei zerebrovaskulären Erkrankungen mit der Darstellung einzelner intrakranieller Arterien und zerebraler Perfusionsterritorien im klinischen Alltag sinnvoll und durchführbar? Material und Methoden: Möglichkeiten und Nutzen der nicht invasiven MR-Methoden (superselective pCASL) werden an Probanden und Patienten mit Metastase, Meningeom, arteriovenöser Malformation und Fistel beispielhaft gezeigt. Ergebnisse: Die einzeln markierten Gefäße und Perfusionsterritorien sind bei allen untersuchten Personen klar abzugrenzen und die Blutversorgung der Läsion des Patienten daraus abzuleiten. Schlussfolgerung: Die vielversprechenden superselektiven ASL-Techniken erzielen zu herkömmlichen Bildgebungsmethoden vergleichbare Ergebnisse und können bei bestimmten Patienten mit weiterführenden Informationen zur Therapieplanung beitragen.

Summary

Objective: Are superselective perfusion and angiography measurements with arterial spin labeling (ASL) applied to diverse cerebrovascular diseases adequate and feasible in clinical use to describe distinct intracranial arteries and cerebral perfusion territories? Material and methods: The potential and benefits of the non-invasive MRI-methods (superselective pCASL) are illustrated by measurements with volunteers and patients suffering from metastasis, meningioma, arteriovenous malformation and fistula. Results: It was possible to differentiate the labeled vessels and perfusion territories from all examined individuals. The blood supply of the patient’s lesion could be inferred. Conclusion: Superselective ASL-methods seem very promising and achieved comparable results to conventional imaging techniques. Particular patients could benefit from additional information obtained from ASL for their treatment strategy.

Schlüsselwörter

Arterielle Spinmarkierung - gefäßselektiv - nicht invasiv - Perfusionsterritorien - selektive Angiografie

Keywords

Arterial spin labeling - vessel-selective - noninvasive - perfusion territories - selective angiography

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