Sex in the brain

Summary

The interest in neurobiological correlates of sexuality as well as the hope for a better understanding of sexual dysfunction or phenomena like transvestism and paedophilia has inspired several functional imaging studies in the past years. Brain regions related to sexual stimulation and arousal were identified and differences in the processing of sexual stimuli between men and women and between homo- and heterosexual subjects were suggested. Concerning sexual dysfunction, the investigations allow speculating on neurobiological correlates of the respective problems. Imaging sexual arousal using functional neuroimaging techniques thus can be of use in the development of new therapeutic options concerning pharmacological treatment as well as psychotherapy of sexual dysfunction.

Keywords

Sexuality - fMRI - sex differences - sexual orientation

• Literatur

• 1 Aharon I. et al. Beautiful faces have variable reward value: fMRI and behavioral evidence. Neuron 2001; 32 (03) 537-51.
• 2 Aizenberg D. et al. Comparison of sexual dysfunction in male schizophrenic patients maintained on treatment with classical antipsychotics versus clozapine. J Clin Psychiatry 2001; 62: 541-4.
• 3 Aizenberg D. et al. Sexual dysfunction in male schizophrenic patients. J Clin Psychiatry 1995; 56: 137-41.
• 4 Allen LS, Gorski RA. Sexual orientation and the size of the anterior commissure in the human brain. Proc Natl Acad Sci USA 1992; 89 (15) 7199-202.
• 5 Archer JS. et al. Effect of estradiol versus estradiol and testosterone on brain-activation patterns in postmenopausal women. Menopause 2006; 13 (03) 528-37.
• 6 Arnow BA. et al. Brain activation and sexual arousal in healthy, heterosexual males. Brain 2002; 125 (Pt 5): 1014-23.
• 7 Beauregard M, Levesque J, Bourgouin P. Neural correlates of conscious self-regulation of emotion. J Neurosci 2001; 21 (18) RC165.
• 8 Berglund H, Lindstrom P, Savic I. Brain response to putative pheromones in lesbian women. Proc Natl Acad Sci USA 2006; 103 (21) 8269-74.
• 9 Blaustein JD. Neuroendocrine regulation of feminine sexual behavior: lessons from rodent models and thoughts about humans. Annu Rev Psychol 2008; 59: 93-118.
• 10 Buhler M, Vollstadt-Klein S, Klemen J, Smolka MN. Does erotic stimulus presentation design affect brain activation patterns? Event-related vs. blocked fMRI designs. Behav Brain Funct 2008; 04: 30.
• 11 Clayton AH. Female sexual dysfunction related to depression and antidepressant medications. Curr Womens Health Rep 2002; 02: 182-7.
• 12 Clayton AH. et al. Prevalence of sexual dysfunction among newer antidepressants. J Clin Psychiatry 2002; 63: 357-66.
• 13 Dreher JC. et al. Menstrual cycle phase modulates reward-related neural function in women. Proc Natl Acad Sci USA 2007; 104 (07) 2465-70.
• 14 Dressing H. et al. Homosexual pedophilia and functional net works – an fMRI case report and literature review. Fortschr Neurol Psychiatr 2001; 69 (11) 539-44.
• 15 Emery DE, Sachs BD. Hormonal and monoaminergic influences on masculine copulatory behavior in the female rat. Horm Behav 1976; 07 (03) 341-52.
• 16 Ethofer T. et al. The voices of seduction: cross-gender effects in processing of erotic prosody. Soc Cogn Affect Neurosci 2007; 02 (04) 334-7.
• 17 Evans SM, Haney M, Foltin RW. The effects of smoked cocaine during the follicular and luteal phases of the menstrual cycle in women. Psychopharmacology (Berl) 2002; 159 (04) 397-406.
• 18 Ferretti A. et al. Dynamics of male sexual arousal: distinct components of brain activation revealed by fMRI. Neuroimage 2005; 26 (04) 1086-96.
• 19 Fisher H, Aron A, Brown LL. Romantic love: an fMRI study of a neural mechanism for mate choice. J Comp Neurol 2005; 493 (01) 58-62.
• 20 Flor-Henry P, Lang RA, Koles ZJ, Frenzel RR. Quantitative EEG studies of pedophilia. Int J Psychophysiol 1991; 10 (03) 253-8.
• 21 Gaffney GR, Berlin FS. Is there hypothalamic-pituitary-gonadal dysfunction in paedophilia? A pilot study. Br J Psychiatry 1984; 145: 657-60.
• 22 Ghadirian AM, Chouinard G, Annable L. Sexual dysfunction and plasma prolactin levels in neuroleptic-treated schizophrenic outpatients. J Nerv Ment Dis 1982; 170: 463-7.
• 23 Gizewski ER. et al. There are differences in cerebral activation between females in distinct menstrual phases during viewing of erotic stimuli: A fMRI study. Exp Brain Res 2006; 174 (01) 101-8.
• 24 Gooren L. The endocrinology of transsexualism: a review and commentary. Psychoneuroendocrinology 1990; 15 (01) 3-14.
• 25 Gore AC. Developmental programming and endocrine disruptor effects on reproductive neuroendocrine systems. Front Neuroendocrinol 2008; 29 (03) 358-74.
• 26 Gregorian RS. et al. Antidepressant-induced sexual dysfunction. Ann Pharmacother 2002; 36: 1577-89.
• 27 Hamann S, Herman RA, Nolan CL, Wallen K. Men and women differ in amygdala response to visual sexual stimuli. Nat Neurosci 2004; 07 (04) 411-6.
• 28 Harris GC, Wimmer M, Aston-Jones G. A role for lateral hypothalamic orexin neurons in reward seeking. Nature 2005; 437 (7058): 556-9.
• 29 Herz RS. Cahill Differential use of sensory information in sexual behavior as a function of gender. Hum Nature 1997; 08: 275-286.
• 30 Jackson LR, Robinson TE, Becker JB. Sex differences and hormonal influences on acquisition of cocaine self-administration in rats. Neuropsychopharma-cology 2006; 31 (01) 129-38.
• 31 Jeong GW. et al. Assessment of cerebrocortical regions associated with sexual arousal in premeno-pausal and menopausal women by using BOLD-based functional MRI. J Sex Med 2005; 02 (05) 645-51.
• 32 Kafka M P. A monoamine hypothesis for the pathophysiology of paraphilic disorders. Arch Sex Behav 1997; 26 (04) 343-58.
• 33 Karama S. et al. Areas of brain activation in males and females during viewing of erotic film excerpts. Hum Brain Mapp 2002; 16 (01) 1-13.
• 34 Kawakami M, Kimura F. Study on the bed nucleus of stria terminalis in relation to gonadotropin control. Endocrinol Jpn 1974; 21 (02) 125-30.
• 35 Kennedy SH. et al. Antidepressant-induced sexual dysfunction during treatment with moclobemide, paroxetine, sertraline, and venlafaxine. J Clin Psychiatry 2000; 61: 276-81.
• 36 Kim SW. et al. Brain activation by visual erotic stimuli in healthy middle aged males. Int J Impot Res 2006; 18 (05) 452-7.
• 37 Knegtering R. et al. A randomized open-label study of the impact of quetiapine versus risperidone on sexual functioning. J Clin Psychopharmacol 2004; 24: 56-61.
• 38 Knutson B, Wimmer GE, Kuhnen CM, Winkielman P. Nucleus accumbens activation mediates the influence of reward cues on financial risk taking. Neuroreport 2008; 19 (05) 509-13.
• 39 Komisaruk BR. et al. Brain activation during vagi-nocervical self-stimulation and orgasm in women with complete spinal cord injury: fMRI evidence of mediation by the vagus nerves. Brain Res 2004; 1024 (1–2): 77-88.
• 40 Kranz F, Ishai A. Face perception is modulated by sexual preference. Curr Biol 2006; 16 (01) 63-8.
• 41 Kruijver FP. et al. Male-to-female transsexuals have female neuron numbers in a limbic nucleus. J Clin Endocrinol Metab 2000; 85 (05) 2034-41.
• 42 LeVay S. A difference in hypothalamic structure between heterosexual and homosexual men. Science 1991; 253 (5023): 1034-7.
• 43 Macdonald S. et al. Nithsdale Schizophrenia Surveys 24: sexual dysfunction. Case-control study. Br J Psychiatry 2003; 182: 50-6.
• 44 Mendez MF. et al. Pedophilia and temporal lobe disturbances. J Neuropsychiatry Clin Neurosci 2000; 12 (01) 71-6.
• 45 Meston CM, Frohlich PF. The neurobiology of sexual function. Arch Gen Psychiatry 2000; 57: 1012-30.
• 46 Montejo AL. et al. Incidence of sexual dysfunction associated with antidepressant agents: a prospective multicenter study of 1022 outpatients. Spanish Working Group for the Study of Psychotropic-Related Sexual Dysfunction. J Clin Psychiatry 2001; 62 Suppl 3: 10-21.
• 47 Montorsi F. et al. Brain activation patterns during video sexual stimulation following the administration of apomorphine: results of a placebo-controlled study. Eur Urol 2003; 43 (04) 405-11.
• 48 Moulier V. et al. Neuroanatomical correlates of penile erection evoked by photographic stimuli in human males. Neuroimage 2006; 33 (02) 689-99.
• 49 Mouras H. et al. Brain processing of visual sexual stimuli in healthy men: a functional magnetic resonance imaging study. Neuroimage 2003; 20 (02) 855-69.
• 50 Northoff G. et al. Functional dissociation between medial and lateral prefrontal cortical spatiotemporal activation in negative and positive emotions: a combined fMRI/MEG study. Cereb Cortex 2000; 10 (01) 93-107.
• 51 Park K. et al. Blood-oxygenation-level-dependent functional magnetic resonance imaging for evaluating cerebral regions of female sexual arousal response. Urology 2001; 57 (06) 1189-94.
• 52 Paul T. et al. Brain response to visual sexual stimuli in heterosexual and homosexual males. Hum Brain Mapp 2008; 29 (06) 726-35.
• 53 Phan KL, Wager T, Taylor SF, Liberzon I. Functional neuroanatomy of emotion: a meta-analysis of emotion activation studies in PET and fMRI. Neuroimage 2002; 16 (02) 331-48.
• 54 Piazza LA. et al. Sexual functioning in chronically depressed patients treated with SSRI antidepressants: a pilot study. Am J Psychiatry 1997; 154: 1757-9.
• 55 Ponseti J. et al. A functional endophenotype for sexual orientation in humans. Neuroimage 2006; 33 (03) 825-33.
• 56 Redoute J. et al. Brain processing of visual sexual stimuli in human males. Hum Brain Mapp 2000; 11 (03) 162-77.
• 57 Sartorius A. et al. Abnormal amygdala activation profile in pedophilia. Eur Arch Psychiatry Clin Neurosci 2008; 258 (05) 271-7.
• 58 Savic I, Berglund H, Lindstrom P. Brain response to putative pheromones in homosexual men. Proc Natl Acad Sci USA 2005; 102 (20) 7356-61.
• 59 Savic I, Lindstrom P. PET and MRI show differences in cerebral asymmetry and functional connectivity between homo- and heterosexual subjects. Proc Natl Acad Sci USA 2008; 105 (27) 9403-8.
• 60 Schiffer B. et al. Brain response to visual sexual stimuli in homosexual pedophiles. J Psychiatry Neurosci 2008; 33 (01) 23-33.
• 61 Schiffer B. et al. Functional brain correlates of heterosexual paedophilia. Neuroimage 2008; 41 (01) 80-91.
• 62 Schiffer B. et al. Structural brain abnormalities in the frontostriatal system and cerebellum in pedophilia. J Psychiatr Res 2007; 41 (09) 753-62.
• 63 Schiltz K. et al. Brain pathology in pedophilic offenders: evidence of volume reduction in the right amygdala and related diencephalic structures. Arch Gen Psychiatry 2007; 64 (06) 737-46.
• 64 Schultz W. Multiple reward signals in the brain. Nat Rev Neurosci 2000; 01 (03) 199-207.
• 65 Stoleru S. et al. Neuroanatomical correlates of visually evoked sexual arousal in human males. Arch Sex Behav 1999; 28 (01) 1-21.
• 66 Swaab DF. Sexual orientation and its basis in brain structure and function. Proc Natl Acad Sci USA 2008; 105 (30) 10273-4.
• 67 Swaab DF, Hofman MA. An enlarged suprachiasmatic nucleus in homosexual men. Brain Res 1990; 537 (1–2): 141-8.
• 68 Teusch L. et al. Different patterns of sexual dysfunctions associated with psychiatric disorders and psychopharmacological treatment. Results of an investigation by semistructured interview of schizophrenic and neurotic patients and methadone-sub-stituted opiate addicts. Pharmacopsychiatry 1995; 28: 84-92.
• 69 Walter M. et al. Distinguishing specific sexual and general emotional effects in fMRI-subcortical and cortical arousal during erotic picture viewing. Neuroimage 2008; 40 (04) 1482-94.
• 70 Walter M. et al. Pedophilia is linked to reduced activation in hypothalamus and lateral prefrontal cortex during visual erotic stimulation. Biol Psychiatry 2007; 62 (06) 698-701.
• 71 Wirshing DA. et al. Sexual side effects of novel anti-psychotic medications. Schizophr Res 2002; 56: 25-30.
• 72 Zhou JN, Hofman MA, Gooren LJ, Swaab DF. A sex difference in the human brain and its relation to transsexuality. Nature 1995; 378 (6552): 68-70.